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CYP450 > Inhibiteurs > Flashcards

Inhibiteurs Flashcards

1
Q

Inhibiteurs puissants du 1A2? (4)

A

-Fluvoxamine
-Ciprofloxacine
-Mexilétine
-Propafénone

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2
Q

Affinité/capacité du 1A2?

A

Faible affinité, forte capacité

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3
Q

Inhibiteurs puissants du 2C9? (4)

A

-Ritonavir
-Sulphénazole
-Fluconazole
-Fluvoxamine

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4
Q

Affinitié/capacité du 2C9?

A

Forte affinité, faible capacité

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5
Q

Inhibiteurs puissants du 2C19? (2)

A

-Fluvoxamine
-Ticlopidine

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6
Q

Affinité/capacité du 2C19?

A

Forte affinité, faible capacité

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7
Q

Inhibiteurs puissants du 2D6? (7)

A

-Quinidine
-Ritonavir
-Fluoxétine
-Norfluoxétine
-Paroxétine
-Bupropion
-Cimétidine

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8
Q

Affinité/capacité du 2D6?

A

Forte affinité, faible capacité

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9
Q

Inhibiteurs du 2E1? (3)

A

-Consommation d’alcool non-chronique
-Disulfiram
-Isoniazide (première dose)

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10
Q

Inhibiteurs puissants du 3A4? (10)

A

-Kétoconazole, Itraconazole
-Ritonavir, Indinavir
-Clarithromycine, Érythromycine
-Diltiazem
-Norfluoxétine
-Norfloxacine, (Ciprofloxacine in vitro)

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CYP450 (2 decks)

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