inheritance, variation and evolution Flashcards
Define meisosis
- Formation of four non-identical cells from one cell
Define mitosis
- Formation of two identical cells from one cell
Describe sexual reproduction
- Involves the joining of male and female gametes (each containing genetic information from the mother or father)
Where does sexual reproduction occur?
- Sperm and egg cells in animals
- Pollen and egg cells in flowering plants
Describe what happens during sexual reproduction
- Two sets of chromosomes (father and mother)
- Each gamete has 23 chromosomes and fuse in fertilisation
- Mixing of genetic information which leads to variety in the offspring
How are gametes formed?
- By meiosis
Describe asexual reproduction
- Involves one parent and no fusion of gametes
Describe what happens during asexual reproduction
- happens using the process of mitosis
- no mixing of genetic information
- leads to clones which are genetically identical to each other and the parent
e.g. bacteria
Explain how meiosis halves the number of chromosomes in gametes
- the cell makes copies of its chromosomes - double the amount of genetic info
- the cell divides twice to form four gametes, each with a single set of
chromosomes - all gametes are genetically different from each other
Explain how fertilisation restores the full number of chromosomes
- gametes (23) join at fertilisation to restore the normal number of
chromosomes (46) - the new cell divides by mitosis to produce many copies - number of cells
increases - embryo forms as more cells are produced
- as the embryo develops cells differentiate
How do cells in reproductive organs divide?
- divide by meiosis to form gametes
- gametes only have one copy of each chromosome
What are the advantages of sexual reproduction?
- produces variation in the offspring - if the environment changes variation gives a survival advantage by natural selection, variation decreases the chance of the whole species becoming extinct
- natural selection can be speeded up by humans in selective breeding - organisms with different desirable characteristics can be bred to produce offspring with even more desirable characteristics
e.g. to increase food production (breeding animals with lots of meat)
What are the advantages of asexual reproduction?
- only one parent needed
- no need to find a mate so it’s more time and energy efficient
- faster than sexual reproduction
- many identical offspring can be produced when conditions are favourable
Explain how malarial parasites reproduce sexually and asexually
- causes malaria (spread by mosquitoes and transferred to humans through a bite)
- reproduce sexually in the mosquito
- reproduce asexually in the human host (in the liver and blood cells).
Explain how fungi reproduce sexually and asexually
- many species can undergo both types of reproduction, releasing
spores which land and become new fungi - spores produced asexually are genetically identical.
- spores are produced sexually when the conditions change, in order to
increase variation and avoid extinction.
Explain how plants reproduce sexually and asexually
- many reproduce sexually using pollen (pollination) which must reach the egg cells in the female parts of another flower - forms seeds.
- strawberry plants reproduce asexually, as they produce runners - new
identical plants grow off the runner. - daffodils reproduce asexually - grow from bulbs and new bulbs can grow
from the main one, producing a new identical plant. - advantageous in plants - can reproduce even if the
flowers have been destroyed by frost or other animals
Describe the structure of DNA
- the genetic material in the nucleus of a cell is composed of a chemical
called DNA - DNA is a polymer made up of two strands forming a double helix
- the DNA is contained in structures called chromosomes.
- between the two strands are the four nitrogenous bases lined up in single rows - they come together to form a series of complementary pairs
Define a gene
- small section of DNA on a chromosome
- each gene codes for a particular sequence of amino acids to make a specific protein
Define a genome
- all the genes coding for all of the proteins within an organism.
Discuss the importance of understanding the human genome
- the whole human genome has now been studied
- has improved our understanding of the genes linked to different types of disease and the treatment of inherited disorders
- helped in tracing human migration patterns from the past
- understanding the human genome will have great importance for medicine in the future.
What is DNA?
- stands for deoxyribonucleic acid
- a polymer made from four different nucleotides
- contains instructions for the body
What are chromosomes?
- structures made up of long molecules of DNA found in the nucleus of a cell
What are nucleotides made up of?
- consists of a common sugar phosphate group with one of the four different bases attached to the sugar
Name the four types of organic bases
- A, C, G, T
What codes for a particular amino acid?
- sequence of three bases is the code for a particular amino acid.
- amino acids are joined together to make a protein
- it is the different types and order of amino acids that determine which type of protein it is
- therefore the order of bases controls the order in which amino acids are assembled to produce a particular protein
What do long strands of DNA consist of?
- alternating sugar and phosphate sections
- attached to each sugar is one of the four bases
What is a DNA polymer made up of?
- repeating nucleotide units
What are the complementary base pairngs?
- A and T
- C and G
Define protein synthesis
- the process of producing a protein from DNA
- if a gene is coded to make a protein, it has been expressed
Explain how protein synthesis works
- DNA contains the genetic code for making a protein, but it cannot move out of the nucleus as it is too big.
- The two strands pull apart from each other, and mRNA nucleotides (messenger RNA: a different type of nucleotide) match to their complementary base on the strand.
- The mRNA nucleotides themselves are then joined together, creating a new strand called the mRNA strand. This is a template of the original DNA.
- The mRNA then moves out of the nucleus to the cytoplasm and onto structures called ribosomes.
- At the ribosomes, the bases on the mRNA are read in threes to code for an amino acid (the first three bases code for one amino acid, the second three bases code for another etc).
- The corresponding amino acids are brought to the ribosomes by carrier molecules.
- These amino acids connect together to form a protein.
- When the chain is complete the protein folds to form a unique 3D structure.
What can proteins be?
- enzymes
- hormones
- structural proteins
Define an enzyme
- biological catalysts that speed up the rate of reaction
Define a hormone
- chemical messengers that send signals around the body
Define a structural protein
- strong proteins in order to form structures such as collagen
What do mutations do?
- change the sequences of bases in DNA
- can be either: insertion, deletion, or substitution
What happens when a base is inserted into he code?
- as they are read in threes, this changes the way it is read.
- it may change all the amino acids coded for after this insertion.
What happens when a base is deleted from the code?
- like insertions they change the way it is read.
- it may change all the amino acids coded for after this deletion
What happens when a base is substituted?
- this will only change one amino acid in the sequence or it may not
change the amino acid (as the new sequence can sometimes still code
for the same amino acid)
How does a change in the type/sequence of amino acids affect DNA?
- affects the way it folds and therefore the structure
What effect does mutation have?
- most mutations do not alter the protein or only do so slightly
- however, some have a serious effect and can change the shape
- the substrate will not fit into the active site so it cannot act as a protein
- a structural protein may lose its shape
Where else can there be mutations?
- in the non-coding parts of DNA that control whether the genes are expressed
What do the non-coding parts of DNA do?
- not all parts of DNA code for proteins.
- non-coding parts of DNA can switch genes on and off
- so variations in these areas of DNA
may affect how genes are expressed
How does variation between two organisms arise?
- the coding DNA that determines the proteins and their activity
- the non-coding DNA that determines which genes are expressed
Define a gamete
- an organism’s reproductive cell (egg in female and sperm in males), which has half the number of chromosomes (23).
Define a chromosome
- a structure found in the nucleus which is made up of a long strand of
DNA
Define a gene (characteristics)
- a short section of DNA that codes for a protein, and therefore contribute to a characteristic.
- some characteristics are controlled by a single gene, such as fur colour in mice and red-green colour blindness in humans.
- however, most characteristics are the result of many different genes interacting.
Define alleles
- the different forms of the gene - humans have two alleles for each gene
as they inherit one from each parent.
Define dominant allele
- only one (out of the two alleles) is needed for it to be expressed and for the corresponding phenotype to be observed.
Define recessive allele
- two copies are needed for it to be expressed and for the corresponding
the phenotype to be observed.
Define homozygous
- hen both inherited alleles are the same (i.e. two dominant alleles or
two recessive alleles).
Define heterozygous
- when one of the inherited alleles is dominant and the other is recessive.
Define genotype
- the combination of alleles an individual has, e.g. Aa
Define phenotype
- the physical characteristics that are observed in the individual, e.g. eye
colour
What do family trees show?
- show the inheritance of different phenotypes over generations in the same family
How do you find the probability of the offspring of two parents having certain genotypes and phenotypes?
- using a punnet square diagram
____I__B___I__b__I
_B__I__BB_I__Bb_I
_b__I__Bb_I_bb__I
How do you represent dominant and recessive characteristics in a punnet square?
- uppercase for dominant
- lowercase for recessive
How do you get a genetic disorder?
- by inheriting certain alleles