Info

Question 0

Active metabolite of Terfenadine. Terfenadine is an antihist and can block Cardiac potassium channel (hERG)

Answer 0

Fexodenadine

-safer antihist

Question 1

Caused by excessive and abnormal collagen deposition in the alveolar interstitium

Answer 1

Pulmonary fibrosis

Question 2

Which enantiomer of thalidomide causes phocomelia

Answer 2

S-enantiomer (teratogen)

R-enantiomer-sedative

Question 3

Acetaminphen is predominantly metabolized by

Answer 3

Glucuronidation and sulfation

Question 4

Enzyme that oxidezes acetaminphen to NAPQI

Answer 4

P450 enzyme

Question 5

Results when the organism’s immune system attacks its own cell

Answer 5

Autoimmunity

Question 6

Methyldopa causes hemolytic anemia by eliciting autoimmune rxn against what antigen?

Answer 6

Rhesus antigen (Rh factors)

Question 7

Hydralazine and isoniazid induces this Antibodies w/c results to lupus-like syndrome

Answer 7

Myeloperoxidase

Procainamide -DNA

Question 8

CCl4 + EtOH = more toxic to the liver

Answer 8

Synergysim

Question 9

Effects produce when admin. Of 2 subs to an animal lead to a toxic response w/c is entirely different fron that of either of the cmpds

Answer 9

Coalitive

Question 10

Effects are opposite and therefore counterbalanced

Answer 10

Fnx’l antagonism

Barbi intoxication (IV admin of NE/metaraminol)

Question 11

An antagonism in toxic responses w/c result to complex frmation

Answer 11

Chem’l

Heparin effect (protamine)

Question 12

An antagonism in toxic responses w/c result to influation of ADME

Answer 12

Dispositional

Osmotic diuretic

Question 13

An antagonism in toxic responses w/c 2 subs interact w/ the same receptor and thereby reduce the toxic response

Answer 13

Receptor antagonism

Depressive effect of morphine(naloxone)

Question 14

Involves cathecholamine release, inh reuptake of NT, stimulates adrenergic receptors

Answer 14

Amphetamine

a-methylphenylethylamine

Question 15

Agent of choice to inactivate coelenterate nematocyst toxin (jellyfish)

Answer 15

Vinegar (acetic acid 5%)

Question 16

Describes the ratio of the toxic dose to therapeutic dose of the drug

Answer 16

Therapeutic index

Question 17

Conditions described by “mad as a hatter”

Answer 17

Hg poisoning

Question 18

Normal anion gap metabolic acidosis is caused by

Answer 18

Cholera

Question 19

Ctive metabolite of phenacitin and acetanilide

Answer 19

Acetaminophen

Question 20

Asthmatic pt w/ allergy to ASA should not be given

Answer 20

Ibuprofen

Question 21

ADR of phenothiazine w/c is irreversible

Answer 21

Tardive dyskinesia

Question 22

Bioassay test used in the Phil in determining toxic level of red tide uses particular insect w/c is:

Answer 22

Bangaw

Question 23

Poisons tht most children under age of six

Answer 23

Fe

Question 24

Pyrethrin id the toxic subs found in the seed of

Answer 24

Chrysanthemum

Question 25

Allergic contact dermatitis is a (type of hypersensitivity)

Answer 25

A delayed IV hypersensitivity rxn

Question 26

Subs w/c is identified as a resp tract carcinogens in human

Answer 26

As

Question 27

Form of mercury causes minamata bay dse

Answer 27

Organic Hg cmpds

Question 28

MOTA of organophosphates found in insecticides

Answer 28

Forming a very stable complex w/ acetylcholinesterase

Question 29

Tetrodotoxin is a selective inh of

Answer 29

Na ion channel

Question 30

Oraganophosphates smell likes

Answer 30

Garlic

Question 31

Aka as Stink damp

Answer 31

hydrogen sulfide

Question 32

Toxic subs found in “tulingan”

Answer 32

Sourine

Question 33

FPN test indicates the presence of

Answer 33

Chlorpromazine