Influenza & Parainfluenza Flashcards
___ immunity is subtype specific
Humoral
HEF protein is the only spike protein contained in Influenza Type
C
Inactivated vaccine usually trivalent dapat composed of;
H3N2, H1N1, B
Interferon induction occurs in influ bc of
CMI response
Alberta Duck H1N1 Type A 35th strain found in 1976
A/ Duck/ Alberta/ 35/ 1976 (H1N1)
Classification of Influ A depends on which type of ___ associate together
HA and NA
Which is not a complication of Influenza
Acute otitis media; Bronchiolitis; Croup; Sinusitis; Myositis; Pneumonia; Reye syndrome
None of those mentioned
Highly pathogenic H5 virus reassorted its genome with those of other influ viruses in ____-> spread to poultry, humans, pigs
Aquatic birds
Which glycoprotein cleaves sialic acid on glycoproteins and removes it from host cell permitting virus dissemination
NA
Reye syndrome involves
encephalitis; febrile seizures
Importance of vaccine
Herd immunity
Amantadine and Rimantadine are ____ inhibitors that has NO effect on Influenza B and C and prevents UNCOATING and VIRAL RELEASE
M2 Proton channel
Influenza A and B every 10-40 years cause seasonal epidemics before being replaced by a different variant
Antigenic drift
All are influ hosts, plus
Whales, Waterfowls, Horses, Humans, Pigs, Seals,
Birds
Antigenic shift occurs through introduction of immunologically distinct __ & ___ molecules in a new human virus
HA, NA
Pandemics are due to antigenic ___ of ___
HA
Most specific lab diagnosis for Influ; best predictor of susceptibility of infection;
Positive result: Absence of agglutination since Abs in serum inhibits agglutination property of virus
Neutrlization test/ HA-inhibition
Which is not a transmission factor for Parainflu A. Respi droplets B. Airborne C. Direct contact D. indirect contact
A
Killed whole virus are inactivated virus vaccine grown in; killed virus injected to muscle
embryonated eggs
Immunity dependent upon localized anti-viral secretory IgA which is _____ compared to long lasting anti-viral serum IgG
strains specific and short-lived
Influenza matures by \_\_\_\_\_\_\_\_\_ at the \_\_\_\_\_\_\_; A. budding, cytoplasm, B. replication, cytoplasm C. budding, cell membrane D. replication, cell membrane
C
Serology of influ uses
paired sea, acute and convalescent
Most of symptoms of Influ affect ___ like RSV
Lower Respi Tract
Guillian Barre syndrome is a risk in vaccines for influ
T
Hongkong flu
H3N2; antigenic shift from H2N2
Treatment for parainflu
on my own
How many serologic types Parainfluenza
4
Which among these are not part of specimen used in influ
A. Gargle
B. Lavage fluid from bronchioles and alveoli
C. Nasal aspirate
D. Nasopharyngeal swab
E. none of the above
E.
Synthetic
neutralising epitope that’s stable and can be used as universal vaccine
Seal bark cough; stridor
infections in kids of parainflu; 2-7 days after infection