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rna viruses > Influenza & Parainfluenza > Flashcards

Influenza & Parainfluenza Flashcards

1
Q

___ immunity is subtype specific

A

Humoral

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2
Q

HEF protein is the only spike protein contained in Influenza Type

A

C

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3
Q

Inactivated vaccine usually trivalent dapat composed of;

A

H3N2, H1N1, B

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4
Q

Interferon induction occurs in influ bc of

A

CMI response

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5
Q

Alberta Duck H1N1 Type A 35th strain found in 1976

A

A/ Duck/ Alberta/ 35/ 1976 (H1N1)

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6
Q

Classification of Influ A depends on which type of ___ associate together

A

HA and NA

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7
Q

Which is not a complication of Influenza

Acute otitis media; Bronchiolitis; Croup; Sinusitis; Myositis; Pneumonia; Reye syndrome

A

None of those mentioned

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8
Q

Highly pathogenic H5 virus reassorted its genome with those of other influ viruses in ____-> spread to poultry, humans, pigs

A

Aquatic birds

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9
Q

Which glycoprotein cleaves sialic acid on glycoproteins and removes it from host cell permitting virus dissemination

A

NA

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10
Q

Reye syndrome involves

A

encephalitis; febrile seizures

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11
Q

Importance of vaccine

A

Herd immunity

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12
Q

Amantadine and Rimantadine are ____ inhibitors that has NO effect on Influenza B and C and prevents UNCOATING and VIRAL RELEASE

A

M2 Proton channel

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13
Q

Influenza A and B every 10-40 years cause seasonal epidemics before being replaced by a different variant

A

Antigenic drift

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14
Q

All are influ hosts, plus

Whales, Waterfowls, Horses, Humans, Pigs, Seals,

A

Birds

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15
Q

Antigenic shift occurs through introduction of immunologically distinct __ & ___ molecules in a new human virus

A

HA, NA

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16
Q

Pandemics are due to antigenic ___ of ___

A

HA

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17
Q

Most specific lab diagnosis for Influ; best predictor of susceptibility of infection;
Positive result: Absence of agglutination since Abs in serum inhibits agglutination property of virus

A

Neutrlization test/ HA-inhibition

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18
Q 
Which is not a transmission factor for Parainflu
A. Respi droplets
B. Airborne
C. Direct contact
D. indirect contact
A

A

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19
Q

Killed whole virus are inactivated virus vaccine grown in; killed virus injected to muscle

A

embryonated eggs

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20
Q

Immunity dependent upon localized anti-viral secretory IgA which is _____ compared to long lasting anti-viral serum IgG

A

strains specific and short-lived

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21
Q 
Influenza matures by \_\_\_\_\_\_\_\_\_ at the \_\_\_\_\_\_\_;
A. budding, cytoplasm, 
B. replication, cytoplasm
C. budding, cell membrane
D. replication, cell membrane
A

C

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22
Q

Serology of influ uses

A

paired sea, acute and convalescent

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23
Q

Most of symptoms of Influ affect ___ like RSV

A

Lower Respi Tract

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24
Q

Guillian Barre syndrome is a risk in vaccines for influ

A

T

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25
Q

Hongkong flu

A

H3N2; antigenic shift from H2N2

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26
Q

Treatment for parainflu

A

on my own

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27
Q

How many serologic types Parainfluenza

A

4

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28
Q

Which among these are not part of specimen used in influ
A. Gargle
B. Lavage fluid from bronchioles and alveoli
C. Nasal aspirate
D. Nasopharyngeal swab
E. none of the above

A

E.

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29
Q

Synthetic

A

neutralising epitope that’s stable and can be used as universal vaccine

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30
Q

Seal bark cough; stridor

A

infections in kids of parainflu; 2-7 days after infection

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31
Q

Match

HA:3::NA:_

A

4, tetramer

32
Q

Principal differential caused by H influ

A

Epiglottitis

33
Q

Antigenic shifts happen to Influenza A only

A

T

34
Q

H9N2

A

1999; Mild disease complete recovery of all patients

35
Q

Parainflu grows well on

A

primary monkey kidney cells

36
Q

For isolation of influenza use the following eggs and cels

A

embryonated; pirmary monkey kidney cells and madlindarby canine kidney cells

37
Q

Match the NA inhibitors

Zanamivir, Osteltamivir to Tamiflu and Relenza

A

ZROT

38
Q

Which among Influ types cause mild febrile illness

A

Type A

39
Q 
Which is not a property of Parainfluenza
A. Linear
B. Negative-sense
C. Segmented
D. Single stranded
E. Icosahedral nucleocapsid
A

C. Non-segmented dapat siya which makes it different from Segmented Influ;
E. Helical- same with Influ

40
Q

Signs and symptoms of influ appear ___ after infection

A

1-4 days

41
Q

Bird flu

A

2003; species specific, infected humans on rare occasions

42
Q

Why do B and C have diff nomenclature (without origin and subtype)

A

few HA and NA types

43
Q

Possible source of H5N1

A

Infected cickens

44
Q

Which is not true abt transmission for Influ
A. Respiratory droplets
B. Direct contact
C. 10 000 to 100 000 000 virons per droplet

A

C. 100k to 1 M dapat

45
Q

ParainfluenzaSerotypes 1-3 do not cause viremia

A

T

46
Q

All pandemics are due to antigenic drift

A

F, shift dapat

47
Q

Ab to NA

A

decrease severity

48
Q

Which serologic type of Parainflu is assoc with bronchiolitis, bronchitis and pneumonia; during summer months

A

HPIV 3

49
Q

Asian flu 1957

A

H2N2; antigenic shifts bw wild ducks and people

50
Q

Tissue that makes host hospitable to growth of certain viruses or bacteria

A

Tissue tropism

51
Q

Spanish flu 1918/Russian 1977

A

H1N1; Russian influe = NO pandemic

52
Q

Syncytia formation

A

characteristic of Parainflu, formed when v protein mediates fusion of cells with neighboring cells

53
Q

Breastfeeding may protect babies from HPIVs due to

A

protective Abs in mother’s milk

54
Q

NICHE, other methods of lab diagnosis

A

NT, IF, CF, HI, Elisa

55
Q 
Which is not one of the most common subtype of Influenza Type A?
A. H1N1
B. H2N2
C. H3N2
D. All are most common
A

B.

56
Q

CMI; which ensures cross protection when memory T cells are reactivated

A

CD8 cytotoxic T cells

57
Q

Which is not a function of HA glycoprotein
A. HAtion of human, horse RBCS
B. Neutralizing Ab response
C. Viral attachment and fusion protein
D. fusion of envelope to membrane at ACIDIC pH

A

A, dapat human, chicken, guinea pig

58
Q

Types of Influenza based on these 2 antigens

A

RNP, M

59
Q 
Which among these do not undergo antigenic drift
A. Type A
B. Type B
C. Type C
D. None of the above
A

D. Lahat sila pero B&C do not undergo SHIFTS

60
Q

Which is a factor in innate resistance

Mucociliary escalator, Surfactants that bind virions, alveolar macrophages

A

All of those mentioned

61
Q

weakened influ virus sprayed into nose

A

Live virus, LAIV

62
Q

HA from recombinant virus

A

Virus subunit

63
Q

These are what causes antigenic drift

A

Point mutations

64
Q

nebulized cold or hot steam and drinking Acetaminophen and ibuprofen is management for

A

Parainflu

65
Q

Laryngotracheobronchitis other name

A

CROUP; most common manifestation of parainfluenza virus

66
Q

Epidemics are due to antigenic ___ of ___

A

HA, NA

67
Q

Genetic Reassortment would include 2 strains infecting a single host together; produces the almost the same new strains

A

F, different na

68
Q

Incubation period Influ

A

18-72 hrs

69
Q

What is the unique characteristic of Influ life cycle

A

snatches 5 prime gap

70
Q

Upper respi tract

A

most commonly affected by Parainflu

71
Q

as prophylaxis for people with allergy to vaccine

A

Amantidine

72
Q

Swine flue

A

2009; H1N1, Mild Pandemic

73
Q

Which is not part of envelope of Parainflu:

F, G, H, HN, VP1

A

VP1

74
Q

Ab to HA

A

protective

75
Q

Club cell function in pathogenesis of Influ

A

in respi tract; has enzyme that cleaves HA that facilitates entry of virus inside epithelial cell

76
Q

which glycoprotein in Parainflu cause formation of syncytia

A

F

77
Q

M2 Ion channel fucntion

A

promotes release of genome for entry into nucleus

rna viruses (2 decks)

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