Influenza Antiviral Agents Flashcards
1
Q
Neuraminidase Inhibitors
A
“Mivirs”
1) Oseltamivir
2) Peramivir
3) Zanamivir
2
Q
Oseltamivir (A)DME
A
Oral prodrug
3
Q
Oseltamivir A(D)ME
A
Low Plasma Protein Binding
4
Q
Oseltamivir AD(M)E
A
Esterase hydrolysis to active carboxylate
5
Q
Oseltamivir ADM(E)
A
Renal, tubular secretion of parent & active metabolite
6
Q
Oseltamivir Half life
A
6-10 hrs (active metabolites)
Dose adjustment for renal issues
7
Q
Zanamivir (A)DME
A
Intranasal (4-25% systemic absorption)
8
Q
Zanamivir A(D)ME
A
Low Plasma Protein Binding
9
Q
Zanamivir AD(M)E
A
Minimal
10
Q
Zanamivir ADM(E)
A
Urine, unchanged (less than 8% of dose)
11
Q
Zanamivir Half life
A
~ 2 hrs
12
Q
Peramivir (A)DME
A
IV single dose
13
Q
Peramivir A(D)ME
A
Low Plasma Protein Binding
14
Q
Peramivir AD(M)E
A
Minimal
15
Q
Peramivir ADM(E)
A
Renal, unchanged