Influenza Flashcards

1
Q

When did the Spanish Flu begin?

A

1918

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2
Q

How many victims?

A

30-60 million

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3
Q

How many Americans does influenza kill every year?

A

40 000

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4
Q

How many genes does the virus have?

A

8

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5
Q

How often do mutations create a supervirus?

A

every 30 years

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6
Q

Symptoms at beginning and before death

A

aches, pains

drowning in bodily fluids, cyanosis

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7
Q

Who is John Oxford?

A

a virologist who researched the origin of influenza at Etaples, France

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8
Q

Who is Jeffery Taubenberger?

A

a molecular pathologist who works for the US Armed Forces Lab in Washington DC and is trying to crack the genetic code of influenza

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9
Q

What happened in Cape Fungston, Kansas?

A
  • on March 11th, 1918, 100 soldiers fell ill during training
  • complained of headaches and sore throat
  • a week later, there were 522 cases
  • raw individuals - not exposed to urban diseases before
  • 48 died of the first wave of influenza, thought to be pneumonia
  • Robert Brown believed in this American origin
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10
Q

How many Americans crossed Atlantic in March, how many followed in April?

A

80 000, 120 000

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11
Q

Who was Manchester’s medical officer and what were his past contributions?

A

James Niven rid the city of tuberculosis, cutting the death rate in half

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12
Q

How did the disease travel through Britain?

A

followed railways, beginning at seaports, moving to London, then spreading to neighbouring cities

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13
Q

Who was Mary Moore?

A

she tracked the disease’s progress

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14
Q

Who was most susceptible and why (theory)?

A

young adults and children were most susceptible

- Jeffery Taubenberger believes that the virus circulated in the 1800s, allowing people to build up immunity

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15
Q

How many recruits were hit by the flu?

A

200 000

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16
Q

What happened to the Hinderburg Line?

A
  • Germans retreated to tunnel (closed environment)
  • Americans fought Germans hand-to-hand to seize the tunnel
  • within a month, after German retreat, 500 people were killed by influenza per week in Berlin
17
Q

British Death Tolls

A

96 towns in England and Wales

- 7,417 deaths compared to 4,482 deaths the week before

18
Q

Identification as virus

A
  • in 1918, thought to be a bacteria
  • 15 years later, identified to be a virus
  • begins in birds, must then move to domestic birds, then cross the species barrier into mammals, then it can finally infect humans
19
Q

How does influenza work?

A
  • depends on host
  • takes over host cells, turns them into centres of reproduction of the virus
  • virus mutates to increase chances of defeating the immune system
20
Q

How many samples in Pathology Institute Archives?

A

70 million, 170 of lung tissue of diseased soldiers

21
Q

Who is Terrence Tumpey?

A
  • combined 1918 flu genes with modern flu genes
  • infected mice
  • healed them using anti-viral drugs