Inflammatory skin disease

Question 1

common causes of irritant contact dermatitis

Answer 1

• non-immunologically mediated rxn caused by the cytotoxic effect of agent, not Th1 and macrophages
• common irritants (friction, moisture)

Question 2

common causes of allergic contact dermatitis

Answer 2

-delayed hypersensitivity Th1-mediated
-if it’s all over, it’s probably due to a topical medication they’re smearing around
-most common: nickel
-#1: Nickel
2. Neomycin
3. Balsam of Peru (sure glad I memorized that one)
4. Fragrance
5.Thimerosal
6. Gold
7. Quarternium-15
8. Formaldehyde
9. Bacitracin
#10: Cobalt

Question 3

common associations of atopic dermatitis

Answer 3

•	Common, particularly in young people.
•	Pruritis plus three or more of:
o	Involvement of skin folds or face
o	History of asthma/hay faver
o	History of xerosis (dry skin)
o	Visible flexural eczema
o	Under 2 years of age
•	Note you often get eosinophilia.
•	Note the "atopic triad"-- allergies, asthma, atopic dermatitis.

Question 4

different patterns of psoriasis

Answer 4

• chronic plaque disease
• guttate
• erythroderma
• erythroderma
• pustular psoriasis

Question 5

co-morbidities of psoriasis

Answer 5

• arthritis
• crohn’s
• persistant low grade inflammation
• obesity
• metabolic syndrome
• CV disease

Question 6

clinical location of seborrheic dermatitis and stasis dermatitis

Answer 6

• scalp

- lower legs

Question 7

cause of seborrheic dermatitis and stasis dermatitis

Answer 7

• Malassezia furfur

- lower extremity edema

Question 8

similarity of drug eruptions and viral exanthems

Answer 8

Drug Eruptions (maculopapular eruptions, morbilliform eruptions, drug rashes)
• Differential diagnosis = Viral exanthem
• (EBV, Enterovirus, Adenovirus, Early HIV, Parvovirus B19, CMV)
• Viral infections enhance the risk of drug eruption

Question 9

drug eruptions due to

Answer 9

• Responsible drugs:

• aminopenicillins
• Sulfonamides
• Cephalosporins
• Anticonvulsants
• Allopurinol

Question 10

difference between immediate type hypersensitivity reactions and delayed type hypersensitivity reactions in the skin (urticaria vs. ACD)

Answer 10

• Acute urticaria represents an immediate type I hypersensitivity reaction mediated by IgE antibodies
• First exposure generates IgE antibodies
• Upon re-exposure, antibody binds to IgE on mast cells and basophils causing degranulation with release of mediators such as histamine

Question 11

stasis dermatitis vs. cellulitis (morphology)

Answer 11

derm: Erythematous papules and thin plaques with scale
cell: Warm, tender, erythematous patches or plaques

Question 12

stasis dermatitis vs. cellulitis (location of inflammation)

Answer 12

derm: epidermis and dermis
cell: dermis and SQ tissue