Inflammatory myopathies

Question 1

Rash seen in dermatomyositis

Answer 1

Gottron’s sign/papules, rash on knuckles and dorsum of hand, knee/elbow rash, linear erythema, scalp rash, V-like sign, shawl sign, mechanics hands

Question 2

Epidemiology of inflammatory myopathies

Answer 2

Teens or old people

Question 3

DM and PM associated with what condition?

Answer 3

Malignancies - particularly breast CA and adenocarcinoma of lung

Question 4

Immune response in DM and PM

Answer 4

DM involve perimysial areas with CD4 cells and PM/IBM involves endomysial with CD8 T cells

Question 5

Organ involvement in inflammatory myopathies

Answer 5

Proximal muscles weakness that’s symmetric, upper 1/3 of esophagus, skin, ILD, arthritis, heart

Question 6

Antibody in inflammatory myopathy

Answer 6

Anti-Jo1; associated with arthritis

Question 7

Inclusion body myositis

Answer 7

Affects men, affects thigh muscle and finger flexors, resistant to steroids

Question 8

Diagnostic features of inflammatory myopathies

Answer 8

Elevated CPK, abnormal EMG

Question 9

Serious complication of giant cell arteritis

Answer 9

Thoracic aortic aneurysms

Question 10

Association of PMR with GCA

Answer 10

1/2 of cases of GCA also have PMR