Inflammatory Markers Flashcards
What is the erythrocyte sedimentation rate (ESR)?
= rate it which RBCs sediment in one hour
What is the erythrocyte sedimentation rate (ESR)?
= rate it which RBCs sediment in one hour
ESR is a marker for..?
Non specific measure of inflammation and malignant disease
What is the principle behind ESR?
- ESR is governed by the balance between pro-sedimentation factors (mainly fibrinogen) and factors resisting sedimentation
- presence of an inflammatory process, a higher proportion of fibrinogen in the blood -> RBCs stick together forming “Rouleaux” stacks
- therefore the RBCs sediment quicker
What is the lag phase between onset of inflammatory stimulation and production proteins that increase ESR?
24-48 hours
What ESR value normally excludes inflammation?
What is C-reactive protein?
CRP is considered the most accurate measure of the acute phase response and therefore tissue inflammation and neoplastic disease
CRP rises within how many hours of inflammation?
6 hours and may double every 8 hour reaching a peak in 50 hours
What are the CRP rules of inflammation (thresholds for inflammation severity)?
4-10 mild inflammation
10-20 moderate inflammation (e.g. viral infection)
> 40 marked inflammation (bacteria infection)
What level of CRP is associated with bacterial infection?
> 100 mg/L
What is the normal value of CRP?
> 10 mg/L
ESR is a marker for..?
Non specific measure of inflammation and malignant disease
What is the principle behind ESR?
- ESR is governed by the balance between pro-sedimentation factors (mainly fibrinogen) and factors resisting sedimentation
- presence of an inflammatory process, a higher proportion of fibrinogen in the blood -> RBCs stick together forming “Rouleaux” stacks
- therefore the RBCs sediment quicker
What is the lag phase between onset of inflammatory stimulation and production proteins that increase ESR?
24-48 hours
What ESR value normally excludes inflammation?
What is C-reactive protein?
CRP is considered the most accurate measure of the acute phase response and therefore tissue inflammation and neoplastic disease
CRP rises within how many hours of inflammation?
6 hours and may double every 8 hour reaching a peak in 50 hours
What are the CRP rules of inflammation (thresholds for inflammation severity)?
4-10 mild inflammation
10-20 moderate inflammation (e.g. viral infection)
> 40 marked inflammation (bacteria infection)
What level of CRP is associated with bacterial infection?
> 100 mg/L
What is the normal value of CRP?
> 10 mg/L
What is C-reactive protein?
CRP is considered the most accurate measure of the acute phase response and therefore tissue inflammation and neoplastic disease
- CRP is considered superior in terms of rapidity of response and specificity for inflammation
What is the normal value of CRP?
> 10 mg/L
Which rises faster - CRP or ESR?
CRP
Which falls faster - CRP or ESR?
CRP
The levels of CRP and ESR are similar after how many hours?
app 24 hours
What diseases presents with v high ESR but normal CRP?
Giant Cell Arteritis
Polymyalgia Rheumatica
