Inflammatory Disorders of the Stomach

Question 1

gastritis can either be ___ or ___

Answer 1

acute or chronic

Question 2

in acute gastritis - They have either_____ something or have ____ injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to ___ sensitively with inflammation

Answer 2

They have either ingested something or have chemical injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to stress sensitively with inflammation

Question 3

what are the causes of chronic gastritis? 3

Answer 3

abc
autoimmune
bacterial
chemical

Question 4

______ is the rarest cause of chronic gastritis

Answer 4

autoimmune

Question 5

what are the characteristics of autoimmune and what is it referred to as clinically?

Answer 5

Vitamin B12, macrocytic anaemia and a form of gastritis

penriscious anaemia

Question 6

autoimmune is associated with circulating antibodies to ___ ___ cells and is an example of ___ ___ autoimmunity

Answer 6

gastric parietal, organ specific

Question 7

what are the antibodies in autoimmune chronic gastritis?

Answer 7

anti-parietal and anti-intrinsic factor

Question 8

what happens to the stomach pathologically in autoimmune chronic gastritis

Answer 8

You get atrophy and intestinal metaplasia in the body of the stomach

Question 9

with autoimmune chronic gastritis there is an increased risk of ____

Answer 9

malignancy

Question 10

what causes anaemia in autoimmune gastritis?

Answer 10

The loss of parietal cells and intrinsic factor deficiency causes anaemia

Question 11

what is the most common cause of chronic gastritis?

Answer 11

H.Pylori

Question 12

The bacteria - H.P- do not invade the body - they just sit within the body cavity and inhabit a niche between the _____ __ surface and ___ ____

Answer 12

The bacteria do not invade the body - they just sit within the body cavity and inhabit a niche between the epithlial cell surface and mucous barrier

Question 13

what do the bacteria look like histologically?

Answer 13

gram negative curvillinear rod

Question 14

H P It excites an early acute inflammatory reaction leading to _____ infiltration. If this is not cleared then you get chronic active inflammation

Answer 14

neutrophil

Question 15

which interleukin is critical in H P gastritis?

Answer 15

IL8

Question 16

the gastritis and damage from HP is what leads to the gastritis we see in____

Answer 16

PUD

Question 17

what does H P gastritis increase the risk of?

Answer 17

• duodenal ulcer
• gastric ulcer
• gastric carcinoma and lymphoma

Question 18

what happens histologically to the cell in HP gastritis

Answer 18

Diffuse thickened antral type mucosa (antral gastritis means more prone to duodenal ulcer)

Question 19

in HP gastritis you get tonnes of inflammatory cells in the ___ ___

Answer 19

lamina propria

Question 20

what causes chemical gastritis , examples 3

Answer 20

NSAIDS, alcohol, bile reflux

Question 21

what feature of these chemicals allow them to have a potent attack mechanism?

Answer 21

they are fat soluble

Question 22

in which patients is bile reflux a common cause of gastric epithelial cell injury?

Answer 22

patients with gastroduodenal motility disorders which may be a primary phenomenon or may follow surgery to the pyloric region

Question 23

what happens histologically in chemical gastritis?

Answer 23

Get marked epithelial regeneration, hyperplasia, congestion and little inflammation

Question 24

chemical gastritis can cause ____ or ____

Answer 24

ulcers or erosions