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GIT > Inflammatory Bowel Diseases > Flashcards

Inflammatory Bowel Diseases Flashcards

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1
Q

All of the following are TRUE about IBD EXCEPT:

A. Immune-mediated
B. May be acute or chronic
C. Infantile IBD in children refers to <2 years or age
D. If a patient has IBD, there is a 10% lifetime risk for a first-degree relative to be affected
E. None of the options

A

E. None of the options

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2
Q

All of the following are TRUE about Ulcerative Colitis EXCEPT

A. Has the highest incidence among 20-29 years old
B. Greatest incidence is among white and Jewish people
C. Female predominance
D. Smoking may prevent the disease
E. None of the options

A

C. Female predominance

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3
Q

All of the following may increase the risk of IBD EXCEPT:

A. High in animal protein
B. High in sugars and sweets
C. High in fish and shellfish
D. High in omega-6 fatty acids
E. High in omega-3 fatty acids
A

E. High in omega-3 fatty acids

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4
Q

Deficiency of IL-10 and IL-10 receptor is mostly associated with what genetic disorder?

A. Turner's syndrome
B. Hermansky-Pudlak
C. Wiskott-Aldrich syndrome
D. IPEX
E. Early-onset IBD
A

E. Early-onset IBD

Turner's = X chromosome
Hermansky=Pudlak = 10q23
WAS = WAS protein
Glycogen storage disease = G6P transport protein
IPEX = FoxP3
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5
Q

Which of the following genes is considered as risk factor for IBD that is shared with asthma?

A. TNFAIP3
B. IL10
C. ORMDL3
D. IL12B
E. IL23R
A

C. ORMDL3

RA = TNFAIP3
Psoriasis = IL23R, IL12B
AS = IL23R
Type1 DM= IL10, PTPN2
SLE = TNFAIP3, IL10
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6
Q

Which of the following cells secret interferon gamma?

A. TH cells
B. TH2 cells
C. TH17 cells
D. Two of the options
E. All of the options
A

A. TH1 cells

TH2 = IL-4, IL-5, IL-13
TH17 = IL-17, IL-21
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7
Q

Which of the following is the most common type of UC?

A. Proctitis
B. Left-sided colitis
C. Distal colitis
D. Pancolitis
E. Extensive colitis
A

A. Proctitis

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8
Q

According to the Montreal classification of extent and severity of UC, how do you categorize this:

Inflammation which extends to the proximal splenic flexure and with normal inflammatory markers

A. E1, S1
B. E1, S2
C. E2, S1
D. E2, S2
E. E3, S1
A

E. E3, S1

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9
Q

When the mucosa is erythematous and resembles sandpaper, how do you categorize the severity of the disease?

A. Mild inflammation
B. Moderate inflammation
C. Severe inflammation
D. None of the options

A

A. Mild inflammation

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10
Q

Which of the following is the most adverse complication of UC?

A. Colon cancer
B. Toxic megacolon
C. Colonic perforation
D. Massive colon hemorrhage
E. Fulminant disease
A

C. Colonic perforation

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11
Q

Ulcerative colitis’ damage is limited to which of the following?

A. Mucosa
B. Superficial submucosa
C. Deep submucosa
D. Muscularis
E. Two of the options
F. All of the options
A

E. Two of the options

Mucosa and superficial submucosa

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12
Q

Which part of the small intestine does Crohn’s disease affects?

A. Duodenum
B. Proximal jejunum
C. Distal jejunum
D. Proximal ileum
E. Terminal ileum
A

E. Terminal ileum = 90%

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13
Q

All of the following are TRUE about Crohn’s disease EXCEPT:

A. Most of the cases involve both small and large intestine
B. Rectum is often spared
C. Continuous lesions
D. May affect any part from the mouth to the anus
E. None of the options

A

C. Continuous lesions

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14
Q

Which of the following is characteristic appearance of CD?

A. Cobblestone
B. Polyps
C. Pseudopolyps
D. Thin mucosal wall
E. Diffuse lesions
A

A. Cobblestone

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15
Q

All of the following are signs and symptoms found in Mild UC EXCEPT:

A. Nocturnal diarrhea
B. Rectal bleeding
C. Tenesmus
D. Weight loss
E. Two of the options
F. None of the options
A

E. Two of the options

Severe = nocturnal/postprandial diarrhea
Moderate to severe = anorexia, nausea, vomiting, fever, weight loss

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16
Q

All features are increased in UC EXCEPT:

A. CRP
B. ESR
C. Platelet count
D. Hemoglobin
E. None of the options
A

D. Hemoglobin

17
Q

Which of the following complications of UC may be due to underlying neoplasia?

A. Toxic megacolon
B. Colonic perforation
C. Strictures
D. Intractable disease
E. Massive colon hemorrhage
A

C. Strictures

18
Q

Intestinal malabsorption in jejunoileitis commonly manifests as all of the following EXCEPT:

A. Anemia
B. Hypoalbuminemia
C. Abetalipoproteinemia
D. Hypocalcemia
E. Hypomagnesemia
A

C. Abetalipoproteinemia

19
Q

Which of the following disease is a cause of niacin deficiency?

A. Pellagra
B. Megaloblastic anemia
C. Hemolytic uremic syndrome
D. Vertebral fractures
E. Hemorrhagic steatorrhea
A

A. Pellagra

20
Q

Which of the following allows direct visualization of the entire-small bowel mucosa?

A. CT
B. MR enterography
C. Wireless capsule endoscopy (WCE)
D. Ultrasound
E. Any of the options
A

C. Wireless capsule endoscopy (WCE)

21
Q

All of the following are serological markers for CD EXCEPT

A. ASCA
B. pANCA
C. Omp-C
D. I2
E. Flagellin
F. None of the options
A

B. pANCA

22
Q

Which of the following dermatologic manifestations of IBD manifests as neutrophilic dermatosis?

A. Erythema nodosum
B. Pyoderma gangrenosum
C. Sweet syndrome
D. Metastatic CD
E. Psoriasis
A

C. Sweet syndrome

23
Q

This disease is asymmetric, polyarticular, and migratory which mostly affect large joints of UE and LE.

A. Peripheral arthritis
B. Ankylosing spondylitis
C. Sacrolitis
D. Osteoarthropathy

A

A. Peripheral arthritis

AS = spine and pelvis

Sacrolitis = asymptomatic

24
Q

This is a disorder characterized by both intrahepatic and extrahepatic bile duct inflammation and fibrosis.

A. Hepatic steatosis
B. Primary sclerosing cholangitis
C. Gall bladder polyps
D. Cholelithiasis

A

B. Primary sclerosing cholangitis (PSC)

25
Q

First line treatment for ulcerative colitis

A. Prednisone
B. Sulfasalazine
C. Methotrexate
D. Metronidazole

A

B. Sulfasalazine

26
Q

Which of the following drugs is mostly likely associated with peripheral neuropathy?

A. Metronidazole
B. Methotrexate
C. Prednisolone
D. Budesonide

A

A. Metronidazole

27
Q

Which of the following drugs is mostly likely associated with tendinitis and tendon rupture?

A. Methotrexate
B. Ciprofloxacin
C. Azathioprine
D. Sulfasalazine

A

B. Ciprofloxacin

28
Q

Which of the following is most common adverse effect of azathioprine and 6-MP which occurs within first few weeks of therapy?

A. Hepatomegaly
B. Pancreatitis
C. Steatorrhea
D. Conjunctivitis

A

B. Pancreatitis

29
Q

All of the following are injected subcutaneously EXCEPT:

A. Infliximab
B. Adalimumab
C. Certolizumab
D. Golimumab

A

A. Infliximab

30
Q

Operation of choice for UC patients

A. Ileostomy
B. Ileal pouch-anal anastomosis
C. Colectomy with IRA
D. Colectomy only

A

B. Ileal pouch-anal anastomosis

31
Q

Which of the following is considered as safest antibiotics to use of CD in pregnancy?

A. Amoxicillin
B. Ampicillin
C. Sulbactam
D. Gentamicin

A

B. Ampicillin

+ Cephalosporins

32
Q

Which of the following is contraindicated in pregnancy?

A. 6-MP
B. Azathioprine
C. Metronidazole
D. Methotrexate

A

D. Methotrexate

33
Q

Which of the following is first line in treatment of mild to moderate Crohn’s disease?

A. Budesonide
B. Sulfasalazine
C. Prednisone
D. Azathioprine

A

A. Budesonide

GIT (3 decks)

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