Inflammatory bowel disease Flashcards
What are some Inflammatory Bowel disease examples?
-crohn’s disease
-ulcerative colitis
Where in the body does Crohn’s disease affect?
-can be found anywhere in the GI tract
(mouth, oesophagus, stomach, LI, SI, rectum, anus)
Doesn’t have to be everywhere - can skip areas
What is the aetiology of Crohn’s disease?
Uknown but thoughts are:
-genetic increased risk
-psychological
-immunological predisposition
-infection with mycobacteria
Symptoms of crohn’s?
-Diarrhoea
-Abdominal pain
-PR bleeding
-small bowel disease (malabsorption, pain)
-mouth - orofacial granulomatosis, ulceration
What sites of GI tract does UC affect?
-only in colon (is continuous so won’t skip sites)
Note: is a more superficial inflammatory disease
Compare UC and Crohn’s
What is Crohn’s disease?
a chronic bowel disease characterised by transmural inflammation and granuloma formation
Get oedema in GI tract walls making it narrower, can get abscesses and sometimes fistulas between adjacent bowel loops
Symptoms of UC?
-diahrroea
-abdominal pain
-PR bleeding
What tx is there for inflammatory bowel disease?
-immunosuppressive tx (systemic steroids - prednisolone, local steroids)
-anti-inflammatory drugs
-non-steroidal immunosuppresants
-Anti-TNFx therapy
Surgical tx for UC/crohn’s?
UC = colectomy - CURES it
Crohn’s = remove obstructed bowel segments, close fistulas, drain abscesses but ultimately NO cure
May result in stoma/bag
Describe orofacial granulomatosis.
associated w/ crohns
-lip and oral swelling from increased capillary leakage and granuloma formation blocking lymphatics
get:
-lip swelling
-angular cheilitis
-cobblestoning
-gingivitis
-ulceration
-microscopic granulomas
How can ulcers be associated with ulcerative colitis?
-haematinic deficiency caused by malabsorption or intestinal bleeding
