Inflammation Lab

Question 1

Describe how fat necrosis occurs.

Answer 1

phospholipid that is damaged serves as a nucleation site for Ca++ that is spilled out of damaged cells and available in high concentration

Question 2

What does the presence of granulomas limit the differential to?

Answer 2

intracellular bacteria: TB, leprosy, cat scratch disease
foreign body: organic or inorganic ie. silicon
sarcodosis

Question 3

Describe the granulomatous pattern of inflammation.

Answer 3

collection of epithelioid histiocytes (macrophage) surrounded by lymphocytes and plasma cells, which may have necrosis at the center

Question 4

Describe the steps in formation of a pneumonia

Answer 4

in the case of a bacterial pneumonia, alveolar macrophages bind the mannose of bacterial cells and directly initiate the complement pathway

chemotaxic factors as part of the complement activation cause neutophilic infiltration and edema of the airways

Question 5

What is a septic infarct.

Answer 5

a particle related to sepsis, a bacteria or necrotic tissue acts as an embolus that causes infarct