Inflammation & Anti-Inflammatories Flashcards
Why is inflammation beneficial?
Allows migration of leukocytes, entry of chemical mediators, destroy invading microbes, fibrin deposition to isolate the injured area.
What is the importance of endothelial cells in inflammation?
Selectively permeable, regulate leukocyte extravasation and immune cell proliferation, release inflammatory mediators, regulate tissue repair through growth factors.
Which inflammatory chemicals have an impact?
IL-1 and TNF~a (cytokines), prostaglandins and leukotrienes, histamine, compliment, kimono system, fibrin.
Explain the difference between traditional NSAID’S and coxibs
NSAIDS - COX 1 —> protect gastric mucosa, platelet aggregation and renal flow.
Coxibs - COX 2 —> inflammatory mediators,
What DMARDS do we need to know?
Folic acid antagonist, putative free-radical scavenger. Inhibit IL-1 and other mediators.
Treatment of acute and underlying gout issues.
Acute —> NSAID’S target pain and inflammation. Used to reduce leukocyte migration into the joint.
Underlying —> inhibition or uric acid synthesis, e.g. allopurinol.
Why can you not suddenly withdraw glucocorticoid use?
Acute adrenal insufficiency will develop. Endogenous ACTH levels will decrease, corticosteroid synthesis reduced & endogenous adrenal androgens decrease.
