Inflammation and Repair

Question 1

rubor

Answer 1

redness

Question 2

tumor

Answer 2

swelling

Question 3

calor

Answer 3

heat

Question 4

dolar

Answer 4

pain

Question 5

functio laesa

Answer 5

loss of function

Question 6

5 steps of inflimation

Answer 6

recognition
recruitment
remove agent
regulation
resolution

Question 7

toll-like receptors

Answer 7

detect viri, bacteria, fungi

Question 8

inflamasome

Answer 8

cytoplasmic protein complex that recognizes dead cells (uric acid, tap, crystals) and induces inflammation..

caspase-1 (activates cytokine IL1-ß)

Question 9

steps in vascular changes

Answer 9

constriction
dilation
increased permeability
stasis

Question 10

what causes the transient vasoconstriction

Answer 10

neurogenic

endothelin

Question 11

where does the follow-up vasodilation occur first

Answer 11

arterioles

erythema or hyperemia

mediated by histamine and nitric acid

Question 12

exudation

Answer 12

fluid movement into interstitum during inflammation

Question 13

exudation

Answer 13

fluid movement into interstitum during inflammation

occurs by endotheilail cell contraction

Question 14

vascular leakage is mediated by

Answer 14

histamine
bradykinin
lukotrienes
Substance P

Question 15

lymphangitis

Answer 15

inflammation of lymphatic vessels

Red Streaks

Question 16

exudation

Answer 16

fluid movement into interstitum during inflammation

occurs by endothelial cell contraction

Question 17

vascular leakage is mediated by

Answer 17

histamine
bradykinin
leukotrienes
Substance P

Question 18

lymphangitis

Answer 18

inflammation of lymphatic vessels

Red Streaks

Question 19

lymphadnitis

Answer 19

inflammation of a lymph node

Question 20

lymphadenopothy

Answer 20

enlargement of the lymph node, non-specific

Question 21

lymphadnitis

Answer 21

inflammation of a lymph node

enlarged TENDER

Question 22

CBC

Answer 22

Neutrophils - Bacteria

Lymphocytes - Viral

Question 23

CBC

Answer 23

Neutrophils - Bacteria

Lymphocytes - Viral

Question 24

leukocytes

Answer 24

secrete growth factor

Question 25

selectins

Answer 25

cause the rolling of leukocytes
bind to sialyl-Lewis X glycoproteins
(lack is leukocyte adhesion deficiency type 2 - More susceptible to bacterial infections)

Question 26

E-selectin receptors on?

Answer 26

endothelial cell - ligand on leukocytes

Question 27

L-selectin receptors on

Answer 27

Leukocytes (neutrophils) - ligand on endothelial cells

Question 28

P-selectin receptor is on

Answer 28

endotheilial cells (from webil-palade bodies by the action of histamine and thrombin… to cell surface) - ligand on leukocytes

Question 29

integrins

Answer 29

cause firm attachment of leukocyte to endothelial cell… (selections are weak)

Question 30

integrins

Answer 30

VCAM (vascular) - bind VLA
ICAM (intercellular) - binds LFA via TNF and IL-1
cause firm attachment of leukocyte to endothelial cell… (selections are weak)

Question 31

transmigration

Answer 31

chemokines drive cell migration
PECAM is the adhesion molecule (on endothelial junctions)
collegians helps get through
once through they use interns to grab fibrin and fibronectin

Question 32

migration

Answer 32

by chemotaxis

stimulated by bacterial products and cytokines, compliment, arachidonic acid metabolites (leukotrienes)

Question 33

migration

Answer 33

by chemotaxis

stimulated by bacterial products and cytokines, compliment, arachidonic acid metabolites (leukotrienes)

Question 34

psedumonias infecton problem

Answer 34

neutrophils continue to be recruited beyond the 24 hour mark

Question 35

eosinophils dominate in

Answer 35

parasitic and hypersensitivity