Inflammation And Immunology Basics Flashcards
What does it mean when you describe a chronic disease as progressive?
Do not resolve and get worse over time.
What can sustained tissue inflammation in chronic conditions cause?
Comorbidities such as pain, behaviour disorders and fatigue.
What happens to the incidence of chronic disease with age?
Increases with age, 85% of people over 85 have 2 or more chronic conditions.
What is the craic with cures for chronic conditions?
They are are and relapse it common
What develops in the body during inflammation?
Tolerance due to tissue healing and immune checkpoints
Immune response
What is inflammation?
The response of the immune system to an insult
What is inflammation characterised as?
Redness
Heat
Swelling
Pain
Dysfunction
What is the purpose of inflammation?
Alter the immune system to danger and triggers immune response and healing.
What happens when inflammation is sustained?
Chronic disease
Comorbidities
What is an allergy?
Caused by inappropriate immune responses to harmless environmental stimuli.
What is the immune system?
Defence against pathogens
What are the 2 systems of the immune system?
Innate immune cells
Adaptive immune cells
What are innate cells?
Rapid but non-specific
What are adaptive cells?
Slow but specific
What are the 2 classes of lymphocytes in innate immunity?
B cells
T cells
What is the function of B cells?
Produce and secrete antibodies
Humoral immunity
What is the function of T cells?
Express surface receptors and kill target cells or provide help for B cells/other T cells.
Cellular immunity
Where do immune cells come from?
Derived from haematopoietic stem cells in the bone marrow
Where do b cells develop?
Bone marrow
Where do T cells develop?
Thymus
Where do mature B and T cells chill?
Circulate in the blood and lymphatics
What are myeloid cells?
Found in all tissues, they are first responders when issues are inflamed.
What are tertiary lymphoid tissue?
Loosely organised tissue which could be the residential tissue memory.
