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Inflammation > Inflammation > Flashcards

Inflammation Flashcards

Srudy

1
Q

Vascular Endothelial adherence molecules from the selectin family

A

P selectin., E selectin, GlyCam 1, CD34

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2
Q

Leukocyte adherence molecules from the selectin family

A

Sialyl Lewis X modified proteins

L selectin

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3
Q

Vascular endothelial adherence molecules integrins

A

I CAM 1

VCAM 1

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4
Q

Leukocyte adherence molecules integrins

A

CD11/CD18 INTEGRINS (LFA1, Mac 1)

VLA 4 Iintegrin

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5
Q

INTEGRINS major role in neutrophil

Monocytes lymphocytes

A

Adhesion arrest transmigration

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6
Q

INTEGRINS major role in neutrophil

Monocytes lymphocytes

A

Adhesion arrest transmigration

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7
Q

INTEGRINS major role in eosinophils monocytes and lymphocytes

A

Adhesion

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8
Q

Chemotactic agents for neutrophils include

A

C5a
Arachdonic acid metabolites
Bacterial products
Ltb4 and cytokines

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9
Q

Chemotactic agents?

A

C5a
LTB4
Bacterial components

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10
Q

What carb do neutrophils and macrophages recognize on foreign particles

A

Mannose and fructose

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11
Q

Major opsins?

A

IgG antibody

C3b and C3bi

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12
Q

Dangerous products of oxygen reduction

A

Peroxide anion O2-
Hydroxyl radicals OH-
Singlet oxygen O-

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13
Q

Neutrophilia

A

Pyogenic infection and tissue destruction

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14
Q

Eosinophilia

A

Allergic disorders and parasite jnfection

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15
Q

Lymphocytes

A

Hronic infection, viral infection

Whooping cough

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16
Q

Monocytosis

A

Infectious mononucleosis

Bacterial infections - tuberculosis, typhoid

17
Q

John hunter

A

In the 18th century was the first to realise that acute inflammation was a beneficial response

18
Q

1880s Ellie metchnikoff discovered

A

The process of phagocytosis

19
Q

George Bernard shaw..

A

Created a play the doctors dilemma anout phagocytosis

20
Q

Thomas lewis

A

Established the concept of chemical mediators of inflammation

21
Q

What are the five types of wbc

A

Neutrophils eosinophils basophils monocytes lymphocytes

22
Q

What is vascular endothelial cells

A

They line the inside of arteries and veins

23
Q

Mast cells release

A

Found in connective tissue and release histamine

24
Q

Endothelial gaps features

A

Effects 20 to 60 micrometer
Mediated by histamin bradykinin leukotrienes, substance P, C5a, C3a
Myosin contraction
Transient

25
Q

Endothelial cell retraction induced by

A

IL1, TNF, IFNY
RESTRUCTURING OF CYTO SKELETON
PROLONGED RESPONSE

26
Q

Leukocyte mediated endothelial injury

A

Neutrophils
Most commonly lungs and glomeruli
Immediate sustained

27
Q

Mediators of vascular transcytosis

A

Vascular endothelial growth factor,

Histamine.

Inflammation (2 decks)

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