Inflammation Flashcards
Inflammation
Histamines = swelling Kinins = vasodilation Prostaglandins = pain Cox 1: protects stomach lining and regulates blood platelets Cox 2: triggers inflammation and pain
NSAIDs
Inhibit prostaglandins
Antipyretic (fever reducing)
Inhibit platelet aggregation (antiplatelet)
Inhibit cox 1 & 2
Exception drugs for HA and fever: aspirin and ibuprofen
1st gen: salicylates & propionic acid derivatives
2nd gen: cox 2 inhibitor
No garlic
Salicylates
Aspirin
Antiinflam, antiplatelet, antipyretic
Can OD
Increased bleeding w anticoagulant
Hypoglycemia w oral anti diabetics
Increased gastric ulcers w glucocorticoid
Increase PT & INR
Avoid prunes, raisins, licorice, spices
Severe poisoning: CV collapse, coma, convulsions
Don’t take w other NSAIDs
Don’t give to children with flu or virus symptoms = Reye syndrome
Dizziness, tinnitus, peptic ulcer formation
Propionic Acid Derivatives
Ibuprofen Inhibits prostaglandin Increased bleeding w warfarin Decreased effect w aspirin Take with food
Selective Cox 2 Inhibitor
Celecoxib
Inhibits cox 2, not 1 = safer on stomach
Decrease inflammation and pain
Peripheral edema
Corticosteroids
Suppress inflammation at injured site
Control arthritic flare ups
Bad for diabetics
Suppress ability to produce cortisol
DMARDs
Use early in disease process
Protect joint function
SE: bone marrow suppression,liver damage, lung infection
Immunosuppressive agents - DMARD
Suppress inflammation of rheumatoid arthritis when other treatments dont work
Immunomodulators - DMARD
Humira Neutralize TNF blockers Disrupt inflammation process Delay disease progression Use for rheumatoid arthritis Contraindicated: active infection & stop if infection occurs SubQ or IV
Antimalarial - DMARD
Treat rheumatoid arthritis if others fail
Takes up to 4-12 weeks to become apparent
Usually in combo w NSAIDs
Antigout - DMARD
Allopurinol Decrease production of uric acid Prophylactic to prevent gout attacks Inflammation disease in joints, tendons and other tissues Avoid organ meats, salmon, alcohol Avoid thiazides Get yearly eye exams Won’t put on meds until flare up happens again
Active immunity
Body produces antibodies
Natural immunity
Acquired immunity
Exposed to allergen
Vaccination
Passive immunity
Receives antibodies from another source
Cocooning
Mother is vaccinated
26-37 weeks