Inflammation Flashcards

1
Q

Inflammation

A
Histamines = swelling
Kinins = vasodilation
Prostaglandins = pain
Cox 1: protects stomach lining and regulates blood platelets
Cox 2: triggers inflammation and pain
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2
Q

NSAIDs

A

Inhibit prostaglandins
Antipyretic (fever reducing)
Inhibit platelet aggregation (antiplatelet)
Inhibit cox 1 & 2
Exception drugs for HA and fever: aspirin and ibuprofen
1st gen: salicylates & propionic acid derivatives
2nd gen: cox 2 inhibitor
No garlic

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3
Q

Salicylates

A

Aspirin
Antiinflam, antiplatelet, antipyretic
Can OD
Increased bleeding w anticoagulant
Hypoglycemia w oral anti diabetics
Increased gastric ulcers w glucocorticoid
Increase PT & INR
Avoid prunes, raisins, licorice, spices
Severe poisoning: CV collapse, coma, convulsions
Don’t take w other NSAIDs
Don’t give to children with flu or virus symptoms = Reye syndrome
Dizziness, tinnitus, peptic ulcer formation

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4
Q

Propionic Acid Derivatives

A
Ibuprofen 
Inhibits prostaglandin 
Increased bleeding w warfarin
Decreased effect w aspirin
Take with food
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5
Q

Selective Cox 2 Inhibitor

A

Celecoxib
Inhibits cox 2, not 1 = safer on stomach
Decrease inflammation and pain
Peripheral edema

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6
Q

Corticosteroids

A

Suppress inflammation at injured site
Control arthritic flare ups
Bad for diabetics
Suppress ability to produce cortisol

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7
Q

DMARDs

A

Use early in disease process
Protect joint function
SE: bone marrow suppression,liver damage, lung infection

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8
Q

Immunosuppressive agents - DMARD

A

Suppress inflammation of rheumatoid arthritis when other treatments dont work

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9
Q

Immunomodulators - DMARD

A
Humira
Neutralize TNF blockers
Disrupt inflammation process
Delay disease progression
Use for rheumatoid arthritis
Contraindicated: active infection & stop if infection occurs
SubQ or IV
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10
Q

Antimalarial - DMARD

A

Treat rheumatoid arthritis if others fail
Takes up to 4-12 weeks to become apparent
Usually in combo w NSAIDs

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11
Q

Antigout - DMARD

A
Allopurinol
Decrease production of uric acid
Prophylactic to prevent gout attacks
Inflammation disease in joints, tendons and other tissues
Avoid organ meats, salmon, alcohol
Avoid thiazides
Get yearly eye exams
Won’t put on meds until flare up happens again
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12
Q

Active immunity

A

Body produces antibodies

Natural immunity

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13
Q

Acquired immunity

A

Exposed to allergen

Vaccination

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14
Q

Passive immunity

A

Receives antibodies from another source

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15
Q

Cocooning

A

Mother is vaccinated

26-37 weeks

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16
Q

Flu vaccine

A

Everyone should get vaccinated WHO CAN
Protects very young, very old and immunocompromised.
Pick what strains will be effective for the year to come

17
Q

TIG

A

Tetanus immune globulin
Passive immunity, short lived
Big wound = surgery, puncture

18
Q

Tdap

A

Adults/older children

Lower doses of diphtheria and pertussis

19
Q

To

A

Tetanus toxoid

Booster for wound/burns

20
Q

DTaP

A

Children
Bigger doses of diphtheria, tetanus, and pertussis
Build immunity

21
Q

Lock jaw

A

Nickname for tdap vaccines

Airway blockage is a huge concern

22
Q

Cell cycle nonspecific

A

Works during any phase of cell cycle
Alkylation agents
Anti tumor antibiotics

23
Q

Cell cycle specific

A

Targets a specific phase of cell cycle
Antimetabolites
Mitotic inhibitors

24
Q

Cancer chemotherapy

A

Not selective to cancer cells (kills everything)
Enhances tumoricidal effects
Anti inflammatory agents suppress tumor growth
Sense of well being and varying degrees of euphoria IN CONJUNCTION WITH CORTICOSTEROIDS
SE: myelosuppression, stomatitis (ulcers of the mouth), ondansetron can reverse effects of GI disturbances, IV administration (extravasation, vesicant), alopecia and infertility

25
Q

Myelosuppression

A

Nadir = 7-10 days after chemo when bone marrow production is the lowest
Anemia
Leukopenia = reverse isolation
Thrombocytopenia = increased bleeding

26
Q

Excavasation

A

Drug is leaked into surrounding tissues

27
Q

Vesicant

A

Lethal to surrounding tissues

28
Q

Cytotoxic drug protection

A

Gloves, gowns, respirators, face shields

29
Q

Targeted therapy

A

Cytostatic - keeps tumor from proliferation
Expensive, more testing
Cancer cell can become resistant (mutates or changes path)
Same rate of death since 60s
Change cancer cell back to normal

30
Q

Biological Response modifiers

A

Interferon beta, & colony stimulating factors
Immunomudulation
Cytotoxic/cytostatic
Promote differentiation of stem cells

31
Q

Interferon beta

A

Treats MS
Reduces incidence of relapse
Slows physical disablilty
Flu-like symptoms = side effects are easier to deal with than disease

32
Q

Colony stimulating factors

A

Regulate growth of bone marrow stem cells
Allow increased doses of drugs
Enhance macrophage abilities

33
Q

Epoetin alpha

A

Treat anemia or chronic renal failure & chemotherapy
Monitor hemoglobin = dont exceed 12g/dL (may lead to stroke or MI)
Performance enhancing drug

34
Q

Filgrastim

A
Granulocyte CSF
Stimulates production of neutrophils 
Prevents neutropenia
Bone pain
Don’t give 24 hr before/after chemo