Inflammation

Question 1

Vasodilation. Increased vascular permeability. Endothelial activation

Answer 1

Histamine

Question 2

Secreted by mast cells and leukocytes

Answer 2

Prostaglandins and leukotrienes

Question 3

Vasodilation, pain, fever

Answer 3

Prostaglandins

Question 4

Increased vascular permeability. Chemotaxis. Leukocyte adhesion and activation

Answer 4

Leukotrienes

Question 5

Secreted by macrophages, mast and endothelial cells

Answer 5

Cytokines (TNFalpha, IL-1, IL-6)

Question 6

Local: endothelial activation (expressing adhesion molecules)
Systemically: Fever, metabolite abnormalities, hypotension (shock)

Answer 6

TNFalpha, IL-1, IL-6

Question 7

Produced by leukocytes and activated macrophages

Answer 7

Chemokines

Question 8

Chemotaxis. Leukocyte activation

Answer 8

Chemokines

Question 9

Produced by leukocytes and mast cells.

Answer 9

PAF

Question 10

Vasodilation. Increased vascular permeability. Leukocyte adhesion. Chemotaxis. Degranulation. Oxidative burst

Answer 10

PAF

Question 11

Plasma (produced in liver)

Answer 11

Complement and Kinin

Question 12

Leukocyte chemotaxis and activation, direct target killing (MAC), vasodilation (mast cell stimulation)

Answer 12

Complement

Question 13

Increased vascular permeability. Smooth muscle contraction. Vasodilation. Pain.

Answer 13

Kinins

Question 14

Histamine, serotonin, and lysosomal enzymes are _____________ cell products

Answer 14

preformed

Question 15

NO produced by _______

Answer 15

macrophages

Question 16

Secreted by T-lymphocytes

Answer 16

IL-17

Question 17

Recruits neutrophils and monocytes

Answer 17

T-17

Question 18

Similar to TNF but greater role in fever

Answer 18

IL-1

Question 19

Systemic effects (acute phase protein response)

Answer 19

IL-6

Question 20

Stimulates expression of endothelial adhesion molecules and secretion of other cytokines. Causes systemic effects

Answer 20

TNF

Question 21

Recruitment of leukocytes to sites of inflammation. Migration of cells in normal tissues

Answer 21

Chemokines

Question 22

Prostanglands, leukotrienes, lipoxine, and thromboxane are __________ derivatives

Answer 22

Archidonic Acid

Question 23

_____________ inhibit phospholipase

Answer 23

Steroids

Question 24

________ and _________ inhibit cyclooxygenase COX1 and COX2 inhibitors

Answer 24

Aspirin

Ibuprofen

Question 25

HETE, leukotrienes, and lipoxin produced from AA by

Answer 25

Lipoxygenase

Question 26

Thromboxane, prostacycline, and prostaglandin produced from AA by

Answer 26

Cyclooxygenase

Question 27

Prostaglandins PGI2 (prostacyclin), PGE1, PGE2, PGD2

Answer 27

Vasodilation

Question 28

Thromboxane A2 | leukotrienes C4, D4, E4

Answer 28

Vasoconstriction

Question 29

Leukotrienes C4, D4, E4

Answer 29

Increased vascular permeability

Question 30

Leukotrienes B4, HETE

Answer 30

Chemotaxis, leukocyte adhesion

Question 31

Bronchospasm

Answer 31

Leukotriene C4, D4, E4

Question 32

Leukotriene A4 and B4

Answer 32

Inhibition of inflammation

Question 33

Causes vasodilation and increased vascular permeability resulting in edema

Answer 33

PGE2 and PGD2

Question 34

Promotes platelet aggregation

Answer 34

Thromboxane

Question 35

Inhibits platelet aggregation

Answer 35

Prostacyclin

Question 36

Histamine and prostaglandins cause ____

Answer 36

vasodilation

Question 37

Prostaglandins and bradykinin cause

Answer 37

pain

Question 38

Lysosomal enzymes of leukocytes and ROS cause

Answer 38

tissue damage

Question 39

IL-1, TNF, and prostaglandins cause

Answer 39

fever

Question 40

TNF, IL-1, chemokines, C3a, C5a, Leukotriene B4 cause

Answer 40

Chemotaxis, leukocyte recruitment and activation

Question 41

Histamine, serotonin, C3a, C5a, Leukotrienes C4, D4, E4 cause

Answer 41

Increased vascular permeability

Question 42

_________ activated macrophages function in tissue repair

Answer 42

Alternatively

Question 43

Secreted by mast cells, basophils, and platelets | MBP

Answer 43

Histamine