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Inflammation > Inflammation > Flashcards

Inflammation Flashcards

1
Q

Vasodilation. Increased vascular permeability. Endothelial activation

A

Histamine

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2
Q

Secreted by mast cells and leukocytes

A

Prostaglandins and leukotrienes

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3
Q

Vasodilation, pain, fever

A

Prostaglandins

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4
Q

Increased vascular permeability. Chemotaxis. Leukocyte adhesion and activation

A

Leukotrienes

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5
Q

Secreted by macrophages, mast and endothelial cells

A

Cytokines (TNFalpha, IL-1, IL-6)

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6
Q

Local: endothelial activation (expressing adhesion molecules)
Systemically: Fever, metabolite abnormalities, hypotension (shock)

A

TNFalpha, IL-1, IL-6

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7
Q

Produced by leukocytes and activated macrophages

A

Chemokines

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8
Q

Chemotaxis. Leukocyte activation

A

Chemokines

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9
Q

Produced by leukocytes and mast cells.

A

PAF

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10
Q

Vasodilation. Increased vascular permeability. Leukocyte adhesion. Chemotaxis. Degranulation. Oxidative burst

A

PAF

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11
Q

Plasma (produced in liver)

A

Complement and Kinin

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12
Q

Leukocyte chemotaxis and activation, direct target killing (MAC), vasodilation (mast cell stimulation)

A

Complement

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13
Q

Increased vascular permeability. Smooth muscle contraction. Vasodilation. Pain.

A

Kinins

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14
Q

Histamine, serotonin, and lysosomal enzymes are _____________ cell products

A

preformed

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15
Q

NO produced by _______

A

macrophages

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16
Q

Secreted by T-lymphocytes

A

IL-17

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17
Q

Recruits neutrophils and monocytes

A

T-17

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18
Q

Similar to TNF but greater role in fever

A

IL-1

19
Q

Systemic effects (acute phase protein response)

A

IL-6

20
Q

Stimulates expression of endothelial adhesion molecules and secretion of other cytokines. Causes systemic effects

A

TNF

21
Q

Recruitment of leukocytes to sites of inflammation. Migration of cells in normal tissues

A

Chemokines

22
Q

Prostanglands, leukotrienes, lipoxine, and thromboxane are __________ derivatives

A

Archidonic Acid

23
Q

_____________ inhibit phospholipase

A

Steroids

24
Q

________ and _________ inhibit cyclooxygenase COX1 and COX2 inhibitors

A

Aspirin

Ibuprofen

25
Q

HETE, leukotrienes, and lipoxin produced from AA by

A

Lipoxygenase

26
Q

Thromboxane, prostacycline, and prostaglandin produced from AA by

A

Cyclooxygenase

27
Q

Prostaglandins PGI2 (prostacyclin), PGE1, PGE2, PGD2

A

Vasodilation

28
Q

Thromboxane A2

leukotrienes C4, D4, E4

A

Vasoconstriction

29
Q

Leukotrienes C4, D4, E4

A

Increased vascular permeability

30
Q

Leukotrienes B4, HETE

A

Chemotaxis, leukocyte adhesion

31
Q

Bronchospasm

A

Leukotriene C4, D4, E4

32
Q

Leukotriene A4 and B4

A

Inhibition of inflammation

33
Q

Causes vasodilation and increased vascular permeability resulting in edema

A

PGE2 and PGD2

34
Q

Promotes platelet aggregation

A

Thromboxane

35
Q

Inhibits platelet aggregation

A

Prostacyclin

36
Q

Histamine and prostaglandins cause ____

A

vasodilation

37
Q

Prostaglandins and bradykinin cause

A

pain

38
Q

Lysosomal enzymes of leukocytes and ROS cause

A

tissue damage

39
Q

IL-1, TNF, and prostaglandins cause

A

fever

40
Q

TNF, IL-1, chemokines, C3a, C5a, Leukotriene B4 cause

A

Chemotaxis, leukocyte recruitment and activation

41
Q

Histamine, serotonin, C3a, C5a, Leukotrienes C4, D4, E4 cause

A

Increased vascular permeability

42
Q

_________ activated macrophages function in tissue repair

A

Alternatively

43
Q

Secreted by mast cells, basophils, and platelets

MBP

A

Histamine

Inflammation (1 decks)

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