Inflammation Flashcards
1
Q
H1 histamine receptor
A
Couples via Gq/11 -> PLCβ -> [Ca]i
Important in inflammation
Targeted by ‘antihistamines’
2
Q
H2 histamine receptor
A
Couples via Gs -> AC -> cAMP
Important in gastric acid secretion
3
Q
H3 histamine receptor
A
Couples via Gi -> AC -> cAMP
Important in CNS- presynaptic inhibition by Ca influx
4
Q
H4 histamine receptor
A
Couples via Gq/11 -> PLCβ -> [Ca]i
Physiological role unknown.