Inflammation Flashcards
What are the signs of inflammation?
Vasodilation, Vascular Permeability, and Recruitment of immune cells.
What is the difference in immune cells of acute vs chronic inflammation?
Acute typically has more edema and more PMNs
Chronic typically has fibroblasts and Macrophages
What is histamine’s role in inflammation?
Released by Basophils/Mast Cells and cause vasodilation, premeability, redness, and pain.
What releases bradykinin?
Endothelial cells release bradykinin and cause vasodilation locally with increased pain/permeability.
How does the complement system contribute to inflammation?
Amplifies the inflammation response, recruits immune cells, chemotaxis, and permeability.
What are acute phase proteins?
Proteins that are present with acute inflammation. C-Reactive Protein and Cytokines IL-1 and TNFalpha.
What protein can be used to measure inflammation?
C-Reactive Protein. A nonspecific test for inflammation
What kind of effects does Adenosine have?
Anti-inflammatory.
What drug can block production of leukotrienes?
Zileuton (blocks 5-Lipoxgenase)
What is a leukotriene antagonist?
Zafirlukast (blocks binding of cysteinyl leukotrienes)
What is an antibody used to prevent TNF-alpha effects?
Infliximab, binds to TNF-alpha preventing their function
What is a TNF-alpha receptor antagonist?
Etanercept
