Inflammation Flashcards

1
Q

ROS des neutrophiles vs Macrophages

A

Neutro

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2
Q

NO neutro vs macro

A

macro

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3
Q

dégranulation macro vs neutro

A

neutro

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4
Q

prod de cytokines macro vs neutro

A

macro

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5
Q

La liaison faible entre l’endo et les leukocytes se fait avec les

A

sélectines

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6
Q

les sélectines sont activées par

A

TNF et IL-1

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7
Q

Comment s’appelle le ligand des intégrines sur la surface endothéliale

A

ICAM-1

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8
Q

Comment s’appelle la molécule qui se lie aux leucocytes pour gérer la diapédèse

A

PECAM-1

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9
Q

Nommer les 3 types de selectin

A

L-leucocyte
E-Endothelium
P-platelets

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10
Q

façons d’activer les leucocytes

A

TLR, récepteur de cytokine, g-protein, phagocytic receptor

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11
Q

phagocytic receptors

A

mannose, opsonin receptors, scavenger

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12
Q

nommer les opsonines majeures (microbes sont taggués avec ces opsonines)

A

-IgG
-C3b du complément

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13
Q

Source et action de l’histamine

A

Mastocytes, basophiles, plaquettes
Vasodilatation, perméabilité et activation de l’endothélium
PRO INFLAMMATOIRE

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14
Q

Source/action prosta

A

Mastocytes, leucocytes
Vasodilat, douleur et fièvre

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15
Q

leukotrienes

A

mastocyte, leukocyte
perméabilité, chimiotactisme, leukocyte activation

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16
Q

TNF, IL1, IL6

A

macro, endothelial cells et mastocytes
local: activation de l’endothelium (adhesion molecules)
syst: fievre (IL1), shock

17
Q

chimiokines

A

leukocytes et macrophages activés
chimiotactisme, activation de leukocytes

18
Q

PAF

A

leukocytes et mastocytes
vasodilatation, permeabilité, chimiotactisme, degranulation, respiratory burst (ROS)

19
Q

complement

A

plasma (produit par le foie)
chimiotactisme, activation leucocytes, MAC, vasodilatation

20
Q

kinines

A

plasma
permeabilité, contraction muscles lisses, vasodilatation, douleur

21
Q

ce qui gère la douleur

A

bradykinine et substance P

22
Q

IL17

A

lymphocytes
recrutement de neutro et mono

23
Q

3 cytokines pour inf chronique

A

IL12, IFN-gamma et IL17

24
Q

Vasodilatation

A

histamine et prosta

25
Q

permeabilité

A

histamine, C3a et C5a, leukotrienes prosta

26
Q

chimiotactisme

A

TNF, IL1, chimiokines, C3a et C5a, leukotrienes

27
Q

fièvre

A

IL1, TNF et prosta

28
Q

douleur

A

prosta, bradikinine, substance P

29
Q

tissue damage

A

lysosomal enzymes of leukocytes et ROS