Inflamatory Skin Flashcards
Small, flaccid suprabasilar bullae with single row of keratinocytes attached to basement membrane.
Acantholysis immediately above basal layer, cells become rounded with a tombstone appearance
Pemphigus vulgaris
Pemphigus vulgaris pathophysiology
IgG against desmoglein 1 & 3 (desmosome components)
or
C3 are present in a fishnet-like pattern in intercellular
Elderly patient, tense bullae, heal without scars
Unilocular, subepidermal, nonacantholytic blisters with festooning of dermal papillae
Infiltrate including eosinophils located in blister cavity and in the dermis
Bullous Pemphigoid
What is the pathophysiology of bullous pemphigoid
*Antibodies to hemidesmosomes
Linear deposition of IgG and C3 along the basement membrane zone
Dermal-epidermal seperation. Subepidermal blistering. Mircrosbcesses that may contain eosinophils. Basal cell vacculization.
Dermatitis herpetiformis
Granular IgA pattern in dermal papillae tips by direct immunofluorescence
Antibodies against gliadin
Dermatitis herpetiformis
Hyperkeratosis and acanthosis, prominent granular cell layer, sawtoothing of rete pegs, bandlike chronic inflammatory infiltrate
Lichen Planus
Small tense blisters with erosions and crusting. Subepidermal blisters with neutrophilic infiltration
IgA disease
What is the pathophysiology of IgA disease?
Linear deposition of IgA along the basement membrane zone of epidermis
Hemorrhage and necrotizing vasculitis in dermal small vessels, which contain IgA
HSP
Fibrinoid necrosis at dermoepidermal junction with liquefactive degeneration and atrophy of epidermis. Edema, small hemorrhages and lymphocytic infiltration upper dermis
Lupus
(IgG, IgM and c5b-c9)
intraepidermal vesicles located predominately in intertriginous area. Suprabasilar and intraepidermal clefting
Acantholysis of keratinocytes resembling a brick wall
Hailey Hailey disease
Mutation of Hailey Hailey disease
(ATP2C1) on chromosome 3q21-q24
