Infective Endocarditis

Question 1

What is the recidivism, re-infection and re-operation rate for IDU-IE post surgery?

Answer 1

Osterdal et al. 2016 - 70% recidivism after 1st surgery, 44% after 2nd surgery

Kim et al. 2015 - 6.2 HR of re-infection of the valve compared to non-IDU IE

IDU-IE have between 2-4 times greater risk of re-operation compared to non IDU-IE and the risk is highest in the 90-180 days after the operation (10x)

Question 2

What is the 1, 5, 10 year survival for IDU-IE and non-IDU IE post surgery?

Answer 2

Goodman-Meza et al. 2019 - Survival at 30-days, one-, five-, and 10-years was 94.3, 81.0, 62.1, and 56.6% in PWID, respectively; and 96.4, 85.0, 70.3, and 63.4% in non-PWID

Kim et al. 2015 - In this study overall 5- and 10-year survival rates were 78.9% ± 6.0% and 69.5% ± 8.3% in IVDUs, respectively; and 76.1% ± 2.6% and 68.7% ± 3.9% in non-IVDUs, respectively

Question 3

What is the most commonly affected valve in IDU-IE?

Answer 3

Tricuspid valve