Infectious Diseases 2

Question 1

Explain how latency works

Answer 1

herpes

• herpes replicates inside epithelial cells, virion travels to sensory neuron - creates a small viral chromosome
• stays inside nucleus, and this is latenct establishment
• safe in nucelues until cellular stress, transcription starts, makes new virion,
• virion goes to epithelial cell, starts replicating = cold sores
• can never get rid of herpes, with you for life