Infectious Disease: Antibiotics

Question 1

UTIs can be treated with…

Answer 1

TMP-SMX, nitrofurantoin, or fosfomycin.

Question 2

CAP can be managed with…

Answer 2

third-generation cephalosporin combined with either a macrolide or doxycycline.

Question 3

Penicillin is never used as empiric coverage, except for __________________

Answer 3

is never used as empiric coverage, except for T. pallidum.

Question 4

What must you remember about the penetration of vancomycin?

Answer 4

It does NOT penetrate the GUT! So if you are using it to treat c.diff, dont give it IV. Give it orally.

Question 5

What do we use when vancomycin has failed us?

Answer 5

For vancomycin-resistant infections, modern alternatives to vancomycin include linezolid, daptomycin, and the fifth-generation cephalosporin ceftaroline, which must be memorized as they have no specific categorization.

Question 6

__________________________________________is the standard antipseudomonal antibiotic and a β-lactam.

Answer 6

Piperacillin/tazobactam (pip/tazo) is the standard antipseudomonal antibiotic and a β-lactam.

Question 7

Alternatives to pip/tazo include _____________________________________________________

Answer 7

Alternatives to pip/tazo include carbapenems like meropenem and the fourth-generation cephalosporin cefepime

Question 8

What broad category of antibiotics do cephalosporins fall under?

Answer 8

Beta Lactams

Question 9

Why cant we assume that a positive culture represents infection?

Answer 9

Colonization or contamination!

Question 10

What is the general approach for treating someone whose sick w/ a bacterial infection?

Answer 10

Start empirically and then deescalate based off of micro results

Question 11

Inhibit cell wall synthesis by binding to specific proteins

Answer 11

Beta Lactams

Question 12

Penicillins, cephalosporins, carbapenems, and monobactams are all

Answer 12

beta lactams