Infectious disease Flashcards

1
Q

Diagnosis of systemic Aspergillosis?

A

Female GSD
Terreus/flavus
Galactomannan antigen sens/spec, more sens serum more spec urine

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2
Q

Atovaquone mechanism of action?

A

Structural analogue of protozoan ubiquinone (coenzyme Q), inhibits aerobic respiration electron flow

Cytauxzoon felis cytb mutations confer resistance

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3
Q

How to treat Cytauxzoon felis?

A

Atovaquone and azithromycin

60 % survive to discharge vs 26 % imidocarb diproprionate

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4
Q

H. capsulatum diagnosis?

A

Hitopath gold standard

Galactomannan antigen sens/spec

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5
Q

Fungal dz in brain/eye - what anti fungal?

A

Fluconazole

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6
Q

What mutation facilitates feline coronavirus systemic spread?

A

S gene mutation - tropism for macrophages

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7
Q

What tick transmits Anaplasma phagocytophilum?

A

Ixodes, transstadial

Morulae in neutrophils, P selectin,

Can infect cats

Morulae cannot be differentiated from E ewingii

IFAT > ELISA for ABs

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8
Q

New FIP treatment?

A

Nucleoside analogue GS-441524 = inhibit virus replication

Long term survival in some, in particular neuro but need higher dose

GC376 - 3C-like protease inhibitor

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