Infectious disease Flashcards
High risk groups with fever
- Young infants, esp those younger than 28 days, because of immaturity of their immune system
- Older infants with high fevers (T > 38C [102.2 G]) who appear ill
- Infants and children who are immunodeficient, have sickle cells disease or have underlying chronic liver, renal, pulmonary or cardiac disease
Bacterial pathogens 0-1 months
- GBS
- E coli
- Listeria monocytogenes
TREAT: ampicillin + gentamicin or cerfotaxime
Bacterial pathogens 1-3 months
- GBS
- E coli
- Listeria monocytogenes
TREAT: ampicillin + cefotaxime (+ vancomycin if bacterial meningitis is suspected)
Bacterial pathogens 3 months - 3 years
- Streptococcus pneumoniae
- Haemophilus influenzae type b
- Neisseria meningitidis
TREAT: cefotaxime (+ vancomycin if bacterial meningitis is suspected)
Bacterial pathogens 3 years - adult
- Streptococcus pneumoniae
- Neisseria meningitidis
TREAT: cefotaxime (+ vancomycin if bacterial meningitis is suspected)
Criteria that indicate an infant is at low risk for serious bacterial infection include
- WBC > 5,000 and < 15,000
- Absolute band count < 1,500
- Normal urinalysis ( < 10 WBCs per high powered field)
- If diarrhea is present, < 5 WBC per high powered field on stool Wright stain
- Normal CSF
Hospitalization is required for
- All infants less than 28 days of age
- Infants between 29 days and 3 months with any of the following: toxic appearance; suspected meningitis, pneumonia, pyelonephritis, bone and soft tissue infections unresponsive to oral antibiotics; patients in social circumstances in which there is uncertain outpatient care and follow up
Fever of unknown origin
Fever lasting longer than 8 days to 3 weeks and when physical examination and preliminary laboratory evaluation have all failed to lead to a diagnosis.
Periodic disorders characterized by spiking fevers at regular monthly intervals
- Familial Mediterranean fever: fever, peritonitis, pleuritis, and monoarthritis
- Periodic fever syndrome or Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome (PFAPA)
- Cyclic neutropenia: neutropenia at time of fever occurring at regular 21 day intervals
Hypoglycorrhachia
Lower CSF glucose
When are corticosteroids effective in meningitis
- Corticosteroids given before or with the 1st dose of antibiotics have been shown to be effective at reducing the incidence of hearing loss in HIB meningitis.
- Efficacy in other causes of bacterial meningitis has not been demonstrated.
Complications from meningitis
- Complication rates are highest with meningitis caused by gram negative organisms followed by S pneumoniae, HIB and N meningitidis
- HEARING LOSS (up to 25%)
- GLOBAL BRAIN INJURY ( 5-10%)
- Other complications: SIADH, seizures, hydrocephalus, brain abscess, cranial nerve palsy, learning disability, and focal neurologic deficits
Bacterial causes of aseptic meningitis
- Mycobacterium tuberculosis (most commonly seen in children younger than 5)
- Borrelia burgdorfrei
- Treponema pallidum
Fungal causes of aseptic meningitis
- Cocidiodes immitis
- Cryptococcus neoformans
- Histoplasmosis capsulatum
Parasitic causes of aseptic meningitis
- Taenia solium (etiologic agent of cystericercosis)
- Toxoplasma gondii (in immunocompromised patients)