Infectious Causes Of Cancer

Question 1

Major mechanism for KSHV transformation is

Answer 1

The viral protein Latency Associated Nuclear Antigen 1 (LANA 1)

Question 2

LANA 1 binds

Answer 2

P53

Question 3

KSHV also plays a role in

Answer 3

Immune evasion & Angiogenesis

Question 4

EBV mediated Transformation

Answer 4

EBNA 2 & LMP 1(latent membrane protein)

Question 5

EBNA 2

Answer 5

Acts as a transcriptional activator for many downstream genes. Unregulates B cell antigens CD21 (binds EBV and activates B cells) and CD23(growth signals)

Alter expression of host oncogene cMYC

Question 6

LMP 1

Answer 6

Believed to act as a constitutive member of TNF reception superfamily. Resemblance to CD40 so mimic B cell activation B cells proliferate with no stop signal creating Anti apoptotic & cytokine genes

Question 7

Tumors consistently have chromosomal translocation

Answer 7

in the region c-myc proto-oncogene (8q24)

Question 8

Hit & Run hypothesis

Answer 8

Viral infection was needed to begin the process of transforming but translocation events in the host cell are necessary factors for maintaining oncogenic status

Question 9

HTLV 1 causes

Answer 9

Adult T cell leukemia/lymphoma

Question 10

Acute transforming

Answer 10

Retrovirus carriers an oncogene which is then incorporated into the host genome under viral promoter

Question 11

Slow transforming

Answer 11

Dwells on location of viral genome is inserted into host genome eg HTLV typically inserts 10kb of TF binding sites