Infectious Flashcards
Penicillin is what type of an antibiotic?
Beta-lactam
What is the true penicillin allergy %, and cross-over % between penicillin and cephalosporins?
<1% true allergy
10% cross-over allergy between pcn and cephalosporins
What is it about cephalosporins that cause the crossover allergy with pcn?
they contain benzylpenicillin
How do beta-lactam atbx work?
inhibit the cross-linking of peptidoglycan [inhibit cell wall synthesis]
3-carbon, 1-nitrogen ring is highly reactive
What 5 types of antibiotics are beta-lactams?
- penicillins
- cephalosporins
- Carbapenems
- Monobactams
- Beta-lactamase inhibitors
What is the timeframe for SSI?
w/n 30d of surgery, or 1 year of prosthetic implant or organ
What are the 6 mechanisms of SSI prevention?
- Preop atbx (so concentration is established by INCISION)
- Glycemic control <200mg/dL
- Normothermia
- optimize oxygenation
- antimicrobial soap before surgery
- alcohol-based skin prep (antiseptic agent)
What is a catheter-associated BSI?
bacteremia or fungemia in pt with CVC and AT LEAST ONE positive blood culture obtained from a peripheral vein
Length of R subclavian CVC?
14cm
Length of R IJ CVC?
15cm
Length of L IJ CVC?
18cm
Length of L subclavian CVC?
17cm
Clostridium Difficicle
spore-forming bacterium
toxins A & B create diarrhea & pseudomembranous coliits
may need subtotal colectomy & ileostomy
What 2 antibiotics can cause Cdiff?
vancomycin
metronidazole
What is the mortality of necrotizing soft tissue infections?
up to 75%
5 infections included in necrotizing soft tissue infections
- gas gangrene
- toxic shock syndrome
- Fournier’s gangrene [genital/perineal area]
- severe cellulitis
- flesh-eating infection
Anesthesia management of necrotizing infections
- resuscitation d/t hemodynamic instability
- release of cytokines
- good IV/A-line/CVC
- blood product availability - do not delay surgical treatment
AT RISK OF MULTIORGAN FAILIURE → ICU
Tetanus neurotoxin & what does it do?
tetanospasmin;
suppresses inhibitory neurons in the spinal cord = generalized skeletal muscle contractions
Tetanospasmin is produced by what?
vegetative forms of Clostridium tetani
What does tetanospasmin do?
trismus (75%) = jaw tightness
neck rigidity
What is the treatment of tetanus?
benzodiazepines
muscle relaxants
- neutralize exotoxin; human anti-tetanus immunoglobin; pcn
How do infants get tetanus?
non-sterile materials used to cut the umbilical cords
What are the 4 types of pneumonia?
- community-acquired (streptococcus pneumoniae = most common)
- Aspiration (s/s can include fulminating arterial hypoxemia, airway obstruction, atelectasis, penumonia)
- postoperative
- ventilator-associated
What is included in the presentation of pneumonia?
fever, chest pain, dyspnea, fatigue, rigors, cough, sputum
pt history (travel, caves, diving, birds/sheep, immunocompromised)
chest xray, + cultures, ↑ WBC