Infections Flashcards
What are the features of gram negative organisms?
Prefers moist environment Colonises abnormal skin and enteric colonisation Endotoxins Variable O antigen Amplification potential Abx resistance
What are the features of gram positives?
Resist drying Colonise normal skin Produce toxins, spores and capsules Produce slime on plastics Abx resistance
In sepsis that is community acquired, unknown source or gut what is a typical abx therapy?
Co amoxiclav and gentamicin
Add vancomycin if ?MRSA
OR
Cefuroxime/ ciprofloxacin and metronidazole and gentamicin
In sepsis that is community acquired, with known skin or soft tissue infection, what is a typical abx therapy?
Flucloxacillin + penicillin
-/+ gentamycin (consider adding cindamycin if group A strep or staph aureus TOXIC SHOCK
In sepsis that is community acquired, with known pneumonia, what is a typical abx therapy?
Co amoxiclav and doxycycline
Or
Cefuroxime and erythromycin
In sepsis that is community acquired, and known meningococcal disease, what is a typical abx therapy?
Cefraxone -BD
Can also use penicillin but SIx times a day so not as easy
In sepsis that is hospital acquired, what is a typical abx therapy?
Co amoxiclav and
Gentamycin and piperacillin-taxobactam (tazocin)
NB only if infection is after 48hts of coming to hospital- otherwise treat like community acquired
What 3 organisms can cause renal abscess commonly?
Ecoli
Klebsiella
TB
Which bugs have urinary antigens?
Legionella
Streptococcus pneumoniae
Which bug agglutinates RBCs on blood films?
Mycoplasma pneumonia
What abx do you give for bacterial meningitis cause unknown?
Cefotaxime
Add ampicillin if over 55 (covers listeria)
Give dexamethasone if meningitic
What is the treatment of viral encephalitis?
Aciclovir
Dexamethasone (treats raised ICP)
Anticonvulsants
What causes subacute sclerosing panencephalitis?
Measles
Incidious onset usually after primary infection
What is a complication of frontal sinusitis?
Subdural empyema
If a giloma is methylated, what treatment is it more responsive to?
Temozplamide