Infections Flashcards
Principles of pharmacokinetics
Absorption
Bioavailability
Distribution
Fluid penetration
Tissue concentration
Excretion
Factors affecting drug
-prostatic fluid + tissue penetration
Prostatic fluid penetration
-Lipid solubility
-Degree of ionization in plasma (pKa)
-In case of Water solubility: molecular size + shape
Tissue concentration
-plasma levels related to dose and bioavailability
-drug related:
protein binding qualities
Concentration gradient
Lipid solubility
Plasma half life
-tissue factors: inflammation
Vascularisation
Capillary porosity
(acute inflammation permits better penetration vs chronic infection with fibrosis and scarring)
Why are fluoroquinolones the ideal prostate antibiotic in terms of pharmacokinetics
Small molecular size
High lipid solubility
Low protein binding
Zwitterions(+ve&-ve charged groups)
Excellent prostatic penetration (0.9-2.3xgreater than serum concentration)
Describe 3 zones of renal hydatid cysts
Peripheral : host fibroblasts that may calcify
Intermediate laminated: becomes hyalinised
Germinal:nucleated epithelium gives rise to brood capsules and daughter cysts
