Infections Flashcards
Acute Sore Throat
1st line: Phenoxymethylpenicillin
Penicillin allergy: Clarithromycin
Pregnant: Erythromycin
Influenza Treatment
Oseltamavir (Tamiflu) and Zanamavir (Relenza)
Scarlett Fever Treatment
1st Line: Phenyoxymethylpenicillin
(Pen V)
Penicillin allergy: Clarithromycin
Acute Otitis Media Treatment
1st line: Amoxicillin
2nd: Co-amoxiclav
Penicillin allergy: Clarithromycin
Pregnant: Erythromycin
(?)Acute Otitis Externa Treatment
1st line: Analgesia and apply localised heat.
2nd: Topical Acetic acid-2% (Ear Calm) and Topical Antibiotics/steroids
If cellulitis: Flucloxacillin
Sinusitis Treatment
1st line/Non-life-threatening: Phenoxymethylpenicillin
Penicillin allergy: Doxycycline or Clarithromycin
Pregnancy: Erythromycin
2nd line/Life Threatening: Co-amoxiclav
Treatment for Acute exacerbation of COPD (mild and severe)
Mild: Amoxicillin or Doxycycline or Clarithromycin
Severe: Co-amoxiclav or Co-trimoxazole or Levofloxacin
Acute exacerbation of Bronchiectasis
1st Line: Amoxicillin (preferred in pregnancy) or Doxycycline (not for <12 years old)
In risk of treatment failure: Co-amoxiclav, levofloxacin, ciprofloxacin.
Acute Cough infection treatment (LRTI)
Adults: Doxycycline/Amoxicillin/Clarithromycin
If pregnant: Erythromycin
Children: Amoxicillin/Clarithromycin/ Erythromycin/Doxycycline (Not <12 years old)
Community Acquired Pneumonia Treatment: All severities
Low: Amoxicillin, can also use Clarithromycin/Doxycycline (not under 12)/Erythromycin (pregnancy) CURB65- 0-1
Medium: Amoxicillin and another antibiotic (atypical pathogens suspected!) Clarithromycin and Erythromycin (pregnancy). Penicillin allergy: Doxycycline or Clarithromycin. CURB65 score -2
Severe: Co-amoxiclav + clarithromycin/Erythromycin (pregnancy). Penicillin allergy: Levofloxacin (consider patient safety issues e.g. age, kidney function etc.) CURB65 score- 3-5
Treatment for Community Acquired Pneumonia Treatment in children. All severities
Non-severe :Amoxicillin
Penicillin allergy: Clarithromycin (1month to 17 years) or Doxycycline (12 years-17 years) or erythromycin (8 years to 17 years)
Severe: Co-amoxiclav and* clarithromycin or erythromycin.
*only if atypical pathogen suspected.
Hospital Acquired Pneumonia treatment: all severities
Non-severe: Co-amoxiclav
Alternatives: Doxycycline or Cefalexin or Co-trimoxazole or Levofloxacin
(Co-trimoxazole and Levofloxacin aren’t licensed for this use)
Severe: Specialist Advice required; options include: Piperacillin with tazobactam, ceftriaxone, cefuroxime, ceftazidime, ceftazidime with avibactam, meropenem, Levofloxacin.
Severe HAP and suspected/confirmed MRSA INFECTION. What therapy should be added?
Vancomycin and Teicoplanin along with the IV antibiotics treating the HAP.
Linezolid (if vancomycin can’t be used and specialist advice only)
HAP Treatment (microbial) in children- All severities
Non-severe- Co-amoxiclav
Penicillin allergy: Clarithromycin
Severe- IV antibiotics by specialist options include: Piperacillin with Tazobactam, Ceftazidime, Ceftriaxone.
Urinary tract infection treatment in women
1st line: Nitrofuratoin (if eGFR >45) or trimethoprim.
2nd: Nitrofuratoin, pivmecillinam or fosfomycin (3 days)
Pregnancy: Nitrofuratoin (avoid at term due to risk of neonatal haemolysis)
2nd line: amoxicillin and cefalexin for 7 days.
Urinary Tract Infection treatments for Men
1st line: Trimethoprim
2nd line: Nitrofuratoin for 7 days
Urinary tract infections for children over 3 months
1st line: Nitrofuratoin, Trimethoprim
2nd line: Nitrofuratoin, amoxicillin, cefalexin
Acute Prostatis Treatment
1st line: Ciprofloxacin, ofloxacin, trimethoprim
2nd line: Levofloxacin, Co-trimoxazole
Acute Pyelonephritis (Upper UTI)
1st line in Women: cefalexin, trimethoprim, ciprofloxacin, Co-amoxiclav
1st line in Men: IV Antibiotics (specialist)
Pregnancy: Cefalexin
Children over 3 months: Co-amoxiclav
Prophylactic Recurrent UTI Treatment
Prophylaxis:
1st line: Nitrofuratoin or Trimethoprim
2nd line: amoxicillin or cefalexin
Catheter associated UTI
1st line with no upper UTI symptoms: Nitrofuratoin, Trimethoprim, amoxicillin.
2nd line with no upper UTI symptoms:
Cefalexin, Co-amoxiclav, trimethoprim, ciprofloxacin.
Pregnancy: Cefalexin
Children over 3 months: Trimethoprim, amoxicillin, Co-amoxiclav, Cefalexin
Bacterial Meningococcal Meningitis treatment
IV/IM Benzylpenicillin, cefotaxime, ceftriaxone.
Penicillin allergy: Chloramphenicol
Oral candidiasis treatment
Miconazole gel if not tolerated use Nystatin oral solution.
Fluconazole can be used if severe.
Infectious diarrhoea treatment
If campylobacter suspected: clarithromycin
If giardia suspected: tinidazole
Traveller’s Diarrhoea treatment
Azithromycin
Prophylaxis: Bismuth subsalicylate
Threadworms treatment
Adults and children >6 months: Mebendazole
Children <6 months and pregnancy: only hygiene measures.
C. Difficile infection treatment
1st line: Vancomycin
2nd line: Fidaxomicin
Relapse infection within 12 weeks: Fidaxomicin
Relapse infection after 12 weeks: Vancomycin (and Fidaxomicin if it’s severe)
Helicobacter Pylori treatment
Triple therapy: 2 antibiotics and a PPI
Amoxicillin, clarithromycin and metronidazole are normally considered first line.