Infection Control: Course of Infection By Stage Flashcards

1
Q

What is the incubation period of an infection?

A
  • Interval between pathogen entering the body and first symptoms appearing
  • Examples: Chickenpox 2-3 weeks, common cold 1-2 days, influenza 1-3 days, mumps 15-18 days
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2
Q

What is the prodromal stage?

A
  • Interval from onset of nonspecific symptoms (malaise, low fever, fatigue) to more specific symptoms
  • Microorganisms grow and multiply, patient may be more contagious
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3
Q

What is the illness stage?

A
  • Interval when patient shows signs/symptoms specific to the infection type
  • E.g. cold: sore throat, congestion; mumps: earache, fever, swollen glands
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4
Q

What is the convalescence stage?

A
  • Acute symptoms disappear, body replenishes resources to return to homeostasis
  • Length depends on infection severity and patient’s overall health, can take days to months
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5
Q

Where does the body normally contain microorganisms (normal flora)?

A
  • On the skin surface and deep layers
  • In the saliva and oral mucosa
  • In the gastrointestinal and genitourinary tracts
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6
Q

What role do the normal flora play?

A
  • Do not typically cause disease in their usual areas
  • Participate in maintaining health
  • Assist in fighting infection and inflammation
  • Maintain homeostasis
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7
Q

How do gut microorganisms benefit the host?

A
  • Convert dietary fiber into fatty acids reabsorbed by bowel
  • Synthesize vitamins B, K, bile acids, and sterols
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8
Q

What protects against pathogens invading when normal flora are disrupted?

A
  • Bile’s antibacterial properties
  • Fatty acids stabilizing normal flora populations
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9
Q

What can disrupt the balance of normal flora?

A
  • Acquiring new microorganisms (e.g. in hospital)
  • Use of broad-spectrum antibiotics
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10
Q

What is a risk of using broad-spectrum antibiotics?

A
  • Can lead to superinfection like Clostridioides difficile (C. diff)
  • Eliminates normal flora, reducing body’s defenses
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11
Q

What body systems have unique defenses against infection?

A
  • Skin
  • Respiratory tract
  • Gastrointestinal tract
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12
Q

Why are these systems easily accessible to microorganisms?

A
  • Pathogens can adhere to skin surface
  • Pathogens can be inhaled into lungs
  • Pathogens can be ingested with food
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13
Q

How are the defenses suited to each system’s structure and function?

A
  • Each system has physiologically suited defense mechanisms
  • E.g. Airways lined with cilia to move mucus/trapped organisms
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14
Q

What increases susceptibility to infection?

A
  • Conditions that impair an organ system’s specialized defenses
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15
Q

What is inflammation?

A
  • The body’s cellular response to injury or infection
  • A protective vascular reaction delivering fluid, blood products, and nutrients to injured area
  • Neutralizes and eliminates pathogens or dead tissues
  • Establishes means of repairing cells and tissues
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16
Q

What are signs of localized inflammation?

A
  • Swelling
  • Redness
  • Heat
  • Pain or tenderness
  • Loss of function in affected area
17
Q

What are signs of systemic inflammation/infection?

A
  • Fever
  • Leukocytosis
  • Malaise
  • Anorexia
  • Nausea/vomiting
  • Lymph node enlargement
18
Q

What can trigger the inflammatory response?

A
  • Physical agents (trauma, temperature extremes, radiation)
  • Chemical agents (irritants, poisons, gastric acid)
  • Microorganisms
19
Q

What events occur after tissue injury in the inflammatory response?

A
  • Vascular and cellular responses
  • Formation of inflammatory exudates (fluid/cells discharged)
  • Tissue repair
20
Q

What are the vascular and cellular responses in acute inflammation?

A
  • Arteriole dilation allowing more blood flow to area
  • Increased redness from more local blood circulation
  • Localized warmth from greater blood volume
  • Vasodilation enables blood/WBCs to travel to injured tissues
21
Q

What chemical mediators are released by the body in response to tissue injury?

A
  • Histamine
  • Bradykinin
  • Prostaglandins
  • Serotonin
22
Q

What do these chemical mediators cause?

A
  • Increase permeability of small blood vessels
  • Allow fluid, protein, and cells to enter interstitial spaces
  • Result in localized swelling (edema)
23
Q

What symptom of inflammation results from swelling of tissues?

A
  • Pain, due to increased pressure on nerve endings
  • Chemical substances like histamine stimulate nerve endings
24
Q

What other effect can inflammation have?

A
  • Temporary loss of function in the involved body part
  • E.g. Swollen, painful, discolored fingers from hand infection
25
Q

What is the cellular response in inflammation?

A
  • WBCs (neutrophils and monocytes) arrive at site
  • Pass through blood vessels into tissues
  • Ingest and destroy microbes/particles by phagocytosis
26
Q

What systemic signs develop as inflammation becomes systemic?

A
  • Leukocytosis (increased circulating WBCs)
  • Normal WBC count 5000-10000/mm3, can rise to 15000+
  • Fever from phagocytic release of pyrogens causing hypothalamic change
27
Q

What forms at the site of inflammation?

A
  • Accumulation of fluid
  • Dead tissue cells
  • White blood cells (WBCs)
  • Together forming an exudate
28
Q

What types of exudates can form?

A
  • Serous (clear, watery plasma)
  • Sanguineous (bloody drainage)
  • Serosanguineous (thin, watery, blood-tinged)
  • Purulent (thick drainage containing pus)
29
Q

How is the exudate eventually cleared?

A
  • Through lymphatic drainage
30
Q

What forms a meshlike matrix at the inflammation site?

A
  • Platelets
  • Plasma proteins like fibrinogen
31
Q

What is the purpose of this matrix?

A
  • To prevent the spread of infection
32
Q

What stages are involved in tissue healing after injury?

A
  • Inflammation
  • Proliferation
  • Remodeling
33
Q

What happens to damaged cells during healing?

A
  • They are eventually replaced with healthy new cells
  • The new cells undergo gradual maturation
  • They take on same structural characteristics as previous cells
34
Q

Does the healed wound regain full tensile strength?

A
  • Unless the wound is minor
  • The healed wound usually does not regain full tensile strength of replaced tissue
  • Scarring may occur
35
Q
A