Infection Control Flashcards

Safety precautions, Antibiotics and Immune System Drugs

1
Q

Standard Precautions

A

Standard Precautions apply to 1) blood; 2) all body fluids, secretions, and excretions except sweat, regardless of whether or not they contain visible blood; 3) nonintact skin; and 4) mucous membranes.

Use Standard Precautions, or the equivalent, for the care of all clients.

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2
Q

Handwashing

A

Wash hands after touching blood, body fluids, secretions, excretions, and contaminated items, whether or not gloves are worn.

Wash hands immediately after gloves are removed, between client contacts, and when otherwise indicated to avoid transfer of microorganisms to other clients or environments.

It may be necessary to wash hands between tasks and procedures on the same
client to prevent cross-contamination of different body sites.

Use soap and water for routine handwashing.

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3
Q

GLoves

A
Wear gloves (clean, nonsterile gloves are adequate) when touching blood,
body fluids, secretions, excretions, and contaminated items.

Put on clean gloves just before touching mucous membranes and nonintact skin.

Change gloves between tasks and procedures on the same client after contact
with material that may contain a high concentration of microorganisms.

Remove gloves promptly after use, before touching noncontaminated items
and environmental surfaces, and before going to another client, and wash hands immediately to avoid transfer of microorganisms to other clients
or environments.

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4
Q

Mask

A

Wear a mask and eye protection or a face shield to protect mucous
membranes of the eyes, nose, and mouth during procedures and client-care activities that are likely to generate splashes or sprays of blood, body fluids, secretions, and excretions.

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5
Q

Gown

A

Wear a gown (a clean, nonsterile gown is adequate) to protect skin and to prevent soiling of clothing during procedures and client-care activities that are likely to generate splashes or sprays of blood, body
fluids, secretions, or excretions.

Remove a soiled gown as promptly as possible, and wash hands to avoid transfer of microorganisms to other clients or environments.

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6
Q

Client Care Equipment

A

Handle used client-care equipment soiled with blood, body fluids, secretions, and excretions in a manner that prevents skin and mucous
membrane exposures, contamination of clothing, and transfer of microorganisms to other clients and environments.

Ensure that reusable equipment is not used for the care of another client until it has been cleaned and reprocessed appropriately.

Ensure that single-use items are discarded properly.

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7
Q

Linens

A

Handle, transport, and process used linen soiled with blood, body fluids, secretions, and excretions in a manner that prevents skin and mucous membrane exposures and contamination of clothing and that avoids transfer of microorganisms to other clients and environments.

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8
Q

Needle disposal

A

Used needles and any “sharps” are placed directly into puncture - resistant containers. Do not recap or use two hand technique. Sharps with built-in safety features are used when available.

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9
Q

Contact Precautions

A

Contact Precautions are designed to reduce the risk of transmission of microorganisms by direct or indirect contact.

Direct-contact transmission involves skin-to-skin contact and physical transfer of microorganisms to a susceptible host from an infected or colonized person, such as occurs when personnel turn clients, bathe clients, or perform other client-care activities that require physical contact.

Direct-contact transmission also can occur between two clients.

Indirect-contact transmission involves contact of a susceptible host with a
contaminated intermediate object, usually inanimate, in the client’s environment.

In addition to Standard Precautions, use Contact Precautions, or the equivalent,
for specified clients known or suspected to be infected or colonized with epidemiologically important microorganisms that can be transmitted by direct
contact with the client (hand or skin-to-skin contact that occurs when performing
client-care activities that require touching the client’s dry skin) or indirect contact (touching) with environmental surfaces or client-care items in the client’s
environment.

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10
Q

Contact Precautions: Client Placement, Glove and Handwashing,

A

Client Placement:
Place the client in a private room.
When a private room is not available, place the client in a room with a client(s) who has active infection with the same microorganism but with
no other infection

Glove:
During the course of providing care for a client, change gloves after having contact with infective material that may contain high concentrations of
microorganisms (fecal material and wound drainage).
Remove gloves before leaving the client’s room and wash hands immediately with an antimicrobial agent or a waterless antiseptic agent. For a client with a C. difficile do not use an alcohol-based, hand rub because it is not effective
on C. difficile. Instead use soap and water.

After glove removal and handwashing, ensure that hands do not touch
potentially contaminated environmental surfaces or items in the client’s
room to avoid transfer of microorganisms to other clients or environments.

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11
Q

Contact Precautions: Gown and Client Transport

A

Gowns:
In addition to wearing a gown as outlined under Standard Precautions, wear a gown (a clean, nonsterile gown is adequate) when entering the
room if you anticipate that your clothing will have substantial contact with the client, environmental surfaces, or items in the client’s room, or if
the client is incontinent or has diarrhea, an ileostomy, a colostomy, or wound drainage not contained by a dressing.

Remove the gown before leaving the client’s environment.

After gown removal, ensure that clothing does not contact potentially contaminated environmental surfaces to avoid transfer of microorganisms
to other clients or environments.

Client Transport:
Limit the movement and transport of the client from the room to essential
purposes only.

If the client is transported out of the room, ensure that precautions are maintained to minimize the risk of transmission of microorganisms to other clients and contamination of environmental surfaces or equipment

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12
Q

Aire Borne Precautions

A

Airborne Precautions are designed to reduce the risk of airborne transmission of
infectious agents.

Airborne Precautions apply to clients known or suspected to be infected with pathogens that can be transmitted by the airborne route. In addition to Standard Precautions, use Airborne Precautions, for clients known or suspected to be infected with microorganisms transmitted by airborne droplet nuclei or evaporated droplets containing microorganisms that remain suspended in the air and that can be dispersed widely by air currents within a room or over a long distance.

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13
Q

Airborne Precautions: Client Placement

A

Client Placement:
Place the client in an airborne infection isolation room (AIIR), which is a private room that has: 1) monitored negative air pressure in relation to the
surrounding areas, 2) 6 to 12 air changes per hour, and 3) appropriate discharge of air outdoors or monitored high-efficiency filtration of room air
before the air is circulated to other areas in the hospital.

Keep the room door closed and the client in the room.

Client should have a private room.

When a private room is not available, place the client in a room with a client
who has active infection with the same microorganism but with no other infection.

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14
Q

Airborne Precautions: Resp Protection and Client Transport

A

Respiratory Protection:
Wear respiratory protection (N95 respirator) when entering the room of a client with known or suspected infectious pulmonary tuberculosis.

Susceptible persons should not enter the room of clients known or vsuspected to have measles (rubeola) or varicella (chickenpox) if other immune
caregivers are available. If they must enter, they should wear a respirator mask

Client Transport:
Limit the movement and transport of the client from the room to essential
purposes only.

If transport or movement is necessary, place a surgical mask on the client

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15
Q

Droplet Precautions

A

Droplet Precautions are designed to reduce the risk of droplet transmission
of infectious agents.

Droplet transmission involves contact of the conjunctivae or the mucous
membranes of the nose or mouth of a susceptible person.

Droplets are generated from the source person primarily during coughing,
sneezing, or talking and during the performance of certain procedures such as suctioning and bronchoscopy.

Transmission via large-particle droplets requires close contact between source and recipient persons, because droplets do not remain suspended
in the air and generally travel only short distances, usually 3 ft or less, through the air.

Because droplets do not remain suspended in the air, special air handling and ventilation are not required to prevent droplet transmission.

Droplet Precautions apply to any client known or suspected to be infected with pathogens that can be transmitted by infectious droplets.

In addition to Standard Precautions, use Droplet Precautions, or the equivalent, for a client known or suspected to be infected with microorganisms transmitted by droplets.

Place the client in a private room.

When a private room is not available, place the client in a room with a client(s) who has active infection with the same microorganism but with no
other infection.

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16
Q

Droplet Precautions: Mask and Client Transport

A

In addition to wearing a mask as outlined under Standard Precautions, wear a mask when working within 3 ft of the client. (Logistically, some hospitals may want to implement the wearing of a mask to enter the room.)

Limit the movement and transport of the client from the room to essential purposes
only.

If transport or movement is necessary, place a surgical mask on the client.

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17
Q

Amebiasis/Dysentery

A

Contact precautions.

Spread through Feces.

Isolated for duration of illness until symptom free.

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18
Q

Bronchiolitis

A

Contact Precautions (for infants and young children only).

Spread through respiratory secretions.

Duration of illness until
symptom free. If respiratory
syncytial virus (RSV) antigen positive, refer to RSV.

Various etiologic agents have been associated with this syndrome, i.e., respiratory syncytial virus (RSV), parainfluenza viruses,
adenoviruses, influenza viruses.

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19
Q

Chickenpox (Varicella)

A

Airborne and Contact
Precautions

Airborne droplets and skin lesions are infective

Isolated until all lesions are crusted (at least 5 days after onset of lesions)

Susceptible persons should not enter the room. Persons immune from previous varicella infection may enter the room without a mask. Those immune by vaccination should wear a mask when entering the room. A specially vented room is necessary. The door
to the client’s room should remain closed. The client must wear a mask when leaving their room. Susceptible clients who have been exposed should be placed on Airborne Precautions beginning 10 days after exposure and continuing through day 21 after last
exposure (up to 28 days if VZIG has been given). Clients are
considered infectious 2 days before onset of rash and up to 5 days after onset of lesions. After exposure, use varicella zoster immune
globulin (VSIZ) as recommended by Infectious Diseases Service.

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20
Q

Clostridium difficile enterocolitis

A

Contact Precaution

Spread through feces

Isolated until symptom- free

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21
Q

Common Cold

A

Droplet Precautions (for infants and young children only)

Spread through respiratory secretions

Isolated for duration of illness until symptom free

Rhinoviruses are most frequently associated with the
common cold. Infection is usually mild in adults, but may be severe in infants and young children. Other etiologic agents
such as respiratory syncytial virus (RSV) and parainfluenza
viruses may also cause this syndrome.

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22
Q

Conjunctivitis,

viral (acute hemorrhagic)

A

Contact Isolation

Spread through eye drainage

Isolated until symptom free

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23
Q

Decubitus

ulcer, infected, major

A

Contact Isolation

Spread through Wound drainage

Isolation depends on the extent and condition of the
ulcer.

Major: No dressing or dressing does not adequately
contain drainage.

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24
Q

Diphtheria: Cutaneous

A

Contact precautions - Wound Drainage

Isolation until cultures from infected sites are negative for
Corynebacterium diphtheriae
on two separate days. Collect
cultures > 24 hours apart and
not sooner than 24 hours after
the last dose of antibiotics.
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25
Q

Diphtheria: Pharyngeal

A

Droplet precautions - Respiratory secretions

Isolation until cultures from infected sites are negative for
Corynebacterium diphtheriae
on two separate days. Collect
cultures > 24 hours apart and
not sooner than 24 hours after
the last dose of antibiotics.
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26
Q

Ebola

A

Contact and Droplet Precautions

Infective material is Direct contact through broken skin or mucous membranes (eyes, nose
and mouth) Blood and body fluids Objects contaminated
with Ebola virus (needles/syringes)
Infected animals

Isolated for duration of the illness

Client rooms should have negative pressure and contain their own lab facilities. Those treating clients or entering room should wear PPE: full-body, hazmat suits. Droplet precautions are needed, but health care providers would also wear a
special respirator mask that filters airborne particles, such as an N95 mask. Client needs dedicated medical equipment (preferably disposable)

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27
Q

Epiglottitis

A

Droplet Precautions

Spread through respiratory secretions

Isolated until 24 hours after
start of effective therapy

Epiglottis is often due to Haemophilus influenzae.
Treatment for both systemic infection and carrier state
is needed.
For recommendations regarding prophylaxis after exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

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28
Q

Escherichia coli gastroenteritis
eropathogenic, enterotoxigenic,
enteroinvasive, entero hemorrahagic

A

Contact Precautions

Spread through feces

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29
Q

Fifth’s Disease/ Erythema Infectiosum (Parvovirus B19)

A

Droplet Precautions

Spread through respiratory secretions

Isolated until onset of rash
(not considered infectious after
appearance of rash).

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30
Q

German Measles (Rubella)

A
Droplet Precautions (does
not require room with negative
pressure and external exhaust)

Spread through Respiratory
secretions and urine

Isolated for 7 days after onset of rash

Susceptible persons should not enter the room. Persons
immune by vaccination or natural illness may enter the
room without a mask. Susceptible clients who have
been exposed should be placed on Droplet Precautions
beginning 7 days after exposure and continuing through day 21 after last exposure. Clients are considered infectious a few days before to7 days after onset of rash

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31
Q

German Measles - Congenital Rubella

A
Contact Precautions (does not
require room with negative
pressure and external exhaust)

Spread through Respiratory secretions and urine

Isolation is required during
any admission for the first
year after birth, unless
nasopharyngeal and urine
cultures after 3 months of
age are negative for rubella

Susceptible persons should not enter the room. Persons
immune by vaccination or natural illness may enter the
room without a mask. Susceptible clients who have
been exposed should be placed on Droplet Precautions
beginning 7 days after exposure and continuing through day 21 after last exposure. Clients are considered infectious a few days before to7 days after onset of rash.

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32
Q

Haemophilus influenzae, invasive - Epiglottitis

A

Droplet Precautions

Spread through Respiratory secretion

Isolated until 24 hours after start of effective therapy

Treatment for both systemic infection and carrier state
is needed. For recommendations regarding prophylaxis after exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

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33
Q

Haemophilus influenzae,

invasive - Meningitis

A

Droplet Precautions

Spread through Respiratory secretion

Isolated until 24 hours after start of effective therapy

Treatment for both systemic infection and carrier state
is needed. For recommendations regarding prophylaxis after exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

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34
Q

Haemophilus influenzae,

invasive - Pneumonia

A

Droplet Precautions

Spread through Respiratory secretion

Isolated until 24 hours after start of effective therapy

Treatment for both systemic infection and carrier state
is needed. For recommendations regarding prophylaxis after exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

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35
Q

Hand, foot, and

mouth disease

A

Contact Precautions

Spread through respiratory secretions feces

Isolated for 7 days after onset

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36
Q

Hepatitis, Viral - Type A

A

Contact Precautions (for diapered or incontinent clients)

Spread through Feces

Isolated for duration of the illness

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37
Q

Herpes Simplex -Mucocutaneous Disseminated

severe or primary

A

Contact Precautions

Spread through lesion secretions

Isolated until symptom free

38
Q

Herpes Simplex - Neonatal

A

Contact Precautions

Isolated until lesions dry and crusted

39
Q

Herpes Zoster (Shingles) - Disseminated

A

Airborne and Contact Precautions

Spread through Lesion and respiratory secretions

Isolated until all lesions are crusted

Persons susceptible to varicella should not
enter the room.
Clients who have been exposed should be managed in consultation with Infection
Control.

40
Q

Impetigo

A

Contact Precautions

Spread by lesions

Isolated for 24 hours after
start of effective antibiotic therapy.

41
Q

Influenza

A

Droplet Precautions

Spread through respiratory secretions

Isolated until symptom free

In the absence of an epidemic, influenza may be difficult to diagnose on clinical grounds.
During epidemics, the accuracy of diagnosis increases. Co-horting of clients may be
considered during periods of high census. Immunization is strongly encouraged for health
care providers and clients at risk for serious complications. Contact Infectious Diseases
Service for recommendations regarding the use of prophylaxis for non-immunized persons.

42
Q

Lice

A

Contact Precautions

Spread through infested area

Isolated until effective
treatment has been
completed and room/ personal items adequately disinfected.

Employees with direct contact should be examined for
infestation. Clothing and bedding may be disinfected by machine washing and drying *use hot cycles). Dry cleaning or storing items in a plastic bag for 10 days is also effective. Use of an environmental insecticide is not needed.

43
Q

Measles ( Rubeola, Red Measles)

A
Airborne Precautions (use a
monitored room with negative
pressure and external exhaust)

Spread through respiratory secretions

Isolated for 4 days after onset
of rash. For immunocompromised patients, maintain precautions for
duration of illness.

Promptly notify Infection Control. Susceptible persons should
stay out of the room. All other persons should wear a mask upon entry. A specially vented room is necessary. The client must wear a mask when leaving the room. The door to the client’s
room should remain closed. Susceptible clients who have been exposed should be placed on Airborne Precautions beginning 5 days after exposure and continuing through day 21 after last exposure. Clients are considered infectious 4 days before to 4 days after onset of rash.

44
Q

Meningococcal pneumonia

Neisseria meningitidis

A

Droplet Precautions

Spread through respiratory secretions

Isolated until 24 hours after the start of effective therapy

Treatment for both system infection and carrier state is
needed. For recommendations regarding prophylaxis after
exposure, call infectious Diseases Service (for clients and family) and Occupational Health (for employees).

45
Q

Meningococcemia (meningococcal
sepsis) (Neisseria
meningitidis)

A

Droplet Precautions

Spread through Respiratory Secretions

Isolated until 24 hours after start of effective therapy

Treatment for both systemic infection and carrier state is
needed. For recommendations regarding prophylaxis after
exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

46
Q

Meningitis

Haemophilus influenzae, known or suspected

A

Droplet Precautions

Respiratory secretions

Isolated until 24 hours
after start of
effective therapy

Treatment for both systemic infection and carrier state is
needed. For recommendations regarding prophylaxis after
exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees)

47
Q

Meningitis
Neisseria meningitis
(meningococcal), known or
suspected

A

Droplet Precautions

Respiratory Secretions

Isolated until 24 hours
after start of
effective therapy

Treatment for both systemic infection and carrier state is
needed. For recommendations regarding prophylaxis after
exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees)

48
Q

Meningitis
Viral (aseptic or
nonbacterial)

A

Contact Precautions ( For infants and young children only)

Feces

Isolated for duration of illness until symptom free

Enteroviruses are the most common cause of aseptic
meningitis.

49
Q

Mumps

A
Droplet Precautions
(does not require a
room with negative
pressure and external
exhaust)

Feces

Isolated for 9 days after onset of swelling.

Susceptible personnel who have been exposed should be excluded from work from the 12th day after exposure through the 26th day after exposure, or if symptoms develop until 9 days after the onset of parotitis.

50
Q

Methicillin-resistant Staph. Aureus (MRSA) infection or

colonization

A

Contact Precautions

Wound drainage and/or secretions/ excretions from
colonized/infected sites

Until 2 cultures obtained
after completion of
antibiotic treatment
are negative on 2
separate days, from all
previously colonized/
infected sites (including
nasal colonization, if
applicable).
Previously positive clients
must be placed on Contact
Precautions when readmitted
to the hospital until repeat
cultures are negative as per
criteria under “Duration of
Isolation.”
51
Q

Vancomycin resistant

enterococcus (VRE)

A

Contact Precautions

Wound drainage and/or secretions/ excretions from
colonized/infected sites

Until 2 cultures obtained
after completion of
antibiotic treatment
are negative on 2
separate days, from all
previously colonized/
infected sites (including
nasal colonization, if
applicable).
Previously positive clients
must be placed on Contact
Precautions when readmitted
to the hospital until repeat
cultures are negative as per
criteria under “Duration of
Isolation.”
52
Q

Necrotizing Fasciitis

A

Contact Precautions

Rarely spread from
person to person.
Direct contact
through broken
skin or mucous
membranes (eyes,
nose and mouth)
Blood and body
fluids
Objects
contaminated with
bacteria(needles/
syringes)

Isolated for duration of illness until symptom free and
wounds healed.

Group A strep is considered
the most common cause,
but can also be caused by
Klebsiella, Clostridium, E coli,
Staph aureaus and Aeromonas
hydrophila. Good wound care
is the best prevention. Prompt
treatment with IV antibiotics
is needed. Patients are usually
managed in a burn center or
surgical ICU setting.
53
Q

Pharyngitis

A
Droplet Precautions (for infants
and young children only)

Respiratory Secretions

Isolated until 24 hours after start of effective treatment

54
Q

Plague (Pneumonic)

A

Droplet Precautions

If client requires transport, must have mask on.

55
Q

Pneumonia (Adenovirus)

A

Droplet and Contact
Precautions (for infants
and young children only)

Respiratory secretions and feces

Isolated until symptom free

56
Q

Pneumonia (Bacterial)

A

Droplet Precautions (for infants and young children only)

Respiratory Secretions

Isolated until symptom free

57
Q

Pneumonia ( Etiology unknown)

A
Droplet Precautions (for infants
and young children only). Use
Contact Precautions during RSV season, during an RSV outbreak, or if RSV is in the diagnostic differential. Resume Droplet Precautions if RSV is ruled out.

Respiratory Secretions

Isolated for duration of illness until symptom free. If respiratory syncytial
virus (RSV) antigen
positive, refer to RSV.

58
Q

Pneumonia ( Haemophilus influenzae)

A

Droplet Precautions (for infants and young children only)

Respiratory Secretions

Isolated until 24 hours after
start of effective therapy

59
Q

Pneumonia (Herpes Simplex)

A

Droplet Precautions

Respiratory secretions

Isolated until symptom free

60
Q

Pneumonia - Meingococcal

A

Droplet Precautions

Respiratory Secretions

Until 24 hours after the start of effective therapy

61
Q

Respiratory syncytial virus (RSV) infection or suspected

A

Contact precautions

Respiratory secretions

Until symptom free and
nasopharyngeal antigen test
is negative for RSV (at least
1 week after positive test)
on 2 consecutive days.

To avoid the possibility of false-negative test results, the “calgi swab” method should be used to obtain nasopharyngeal
specimens.

62
Q

Rotavirus infection

A

Contact Precautions

Feces

Duration of illness and stool study negative for rotavirus on 2 separate days

63
Q

SARS

A

Airborne and contact precautions with goggles over eyes

Respiratory droplets

64
Q

Scabies

A

Contact Precautions

Infested area

Isolated for 24 hours after
start of effective therapy and
room/ personal items adequately disinfected.

Employee with direct contact should be examined for infestation. Clothing and bedding may be disinfected by machine washing and drying (use hot cycles). Dry cleaning or
storing items in a plastic bag for 10 days is also effective. Use of an environmental insecticide is
not needed.

65
Q

Scarlet Fever

A

Droplet Precautions (for infants and young children only)

Respiratory Secretions

Isolated for 24 hours after effective therapy

66
Q

Smallpox

A

Airborne and Contact precautions (strict gown/
glove)

Spread through large and small
respiratory droplets, skin lesions, secretions.

Isolated from onset of rash
to separation of scabs (approximately 3 weeks)

Private rooms preferred. In event of large outbreak, clients with same diagnosis can
share respiratory isolation room.
Limit client transport, if necessary, client wears mask

67
Q

Syphilis

A

Skin and mucous
membrane, including congenital, primary, and
secondary

Contact Precautions

Lesion secretions, blood, body fluids spread the disease

Isolated for 24 hours after start of effective therapy

68
Q
Tuberculosis: 
Pulmonary,
confirmed or
suspected (sputum
smear is AFB
positive and/
or chest x-ray
appearance
strongly suggests
active TB, i.e.,
cavitary lesions; or
laryngeal.
A
Airborne Precautions (use a
monitored room with negative
pressure and external exhaust)

Spread through Airborne droplet nuclei

A specially vented room is necessary. The door to the patient’s room should
remain closed. Persons entering the room should wear specially fitted NIOSH
approved respiratory protection. The client should leave the room only for
essential purposes, particularly if the client has multidrug-resistant TB. When
leaving the room, the client should wear a high-filtration surgical mask; for
mechanically-supported ventilation, add a bacterial filter to filter the client’’ exhaled air.

69
Q

Typhoid Fever (Salmonella typhi)

A

Contact precautions (for diapered and incontinent children)

Spread through feces

Isolated for duration of illness - symptom free

70
Q

Whooping cough (pertussis)

A

Droplet Precautions

Spread through respiratory secretions

Isolated for 7 days after start of effective therapy

For recommendations regarding
prophylaxis after exposure, call Infectious Diseases Service (for clients and family) and Occupational Health (for employees).

71
Q

Zika Virus

A

Standard/Contact Precautions only - unless in the labor
and delivery setting. Apply practices and personal protective equipment (PPE) to
prevent exposure as indicated by labor and delivery procedure.

Spread through Body fluids
(blood, urine, saliva and amniotic
fluid).

Pregnancy: Men should
wait for 6 months after
symptoms started (if they
get sick) before trying
to conceive with their
partner. Women should
wait at least 8 weeks after
travel (or 8 weeks after
symptoms started if they
get sick) before trying to
get pregnant. The waiting
period is longer for men
because Zika stays in
semen longer than in
other body fluids.

Patients post exposure should protect themselves for 3 weeks from mosquito bites order to prevent further spread of virus. Zika virus is primarily transmitted through the bite of the mosquito, but sexual transmission has
also been documented. Zika virus RNA has been detected in body fluids (blood, urine,
saliva and amniotic fluid). Zika can also be spread during pregnancy from mother to fetus
causing birth defects. There are no reports of transmission through breastfeeding. CDC
does not recommend Zika virus testing for asymptomatic men, children, or women who
are not pregnant.

72
Q

Aminoglycosides: Tobramycin (Nebcin),
Gentamycin (Garamycin),
Neomycin, Amikacin
(Amikin), Streptomycin*

A
Common Uses:
Serious gram (-)
infections
Given parenterally for
systemic use.
*Generally restricted
to TB treatment.

Contraindications:
Renal disease
Hearing impairment
Pregnancy

Interactions: Increased risk of ototoxicity with loop diuretics.
Increased risk of
nephrotoxicity with
furosemide.

MoA: Interferes with protein synthesis in bacterial cells.
DisAdvantages:
Can cause irreversible ototoxicity and
nephrotoxicity.
Poorly absorbed from the GI tract.
Baseline hearing test recommended

Side Effects:
Confusion Depression,
Numbness Vertigo
Nausea/Vomiting

Adverse Effects:
Seizures
Ototoxicity
Nephrotoxicity
Renal failure
Anaphylaxis
Interventions:
Monitor peak and trough levels.
Monitor BUN and Creatinine levels.
Increase fluids to 1500-2000 mL per day.
I&O
Daily weight

Education:
Teach to report headache or dizziness.
Drink adequate fluids.

73
Q

Antibacterial/Antiprotozoal : Metronidazole

A
H-pylori/GI tract
disorders
UTI
Septicemia
Meningitis

Contraindication:
Pregnancy
Hepatic Disease

PO/IV/Topical
Interactions: Avoid alcohol and alcohol
containing medications
for at least 48 hours after treatment complete.

MoA: Impairs DNA function of susceptible bacteria
Advantages: Dual action on bacteria and protozoa
(parasites).

Side Effects:
Dark/reddish brown urine
Nausea/vomiting
Metallic or bitter taste Headache Dizziness
Depression Irritability
Insomnia 

Adverse Effects:
Thrombophlebitis
Bone marrow suppression
Neurotoxicity

Interventions:
Monitor urine output and color changes
Assess ECG and neuro changes during medication administration
Proper handwashing and hygiene after bowel cleansing.

Education:
DO NOT use alcohol or medications with alcohol for 48
hours after treatment complete.
Teach that urine may turn dark/reddish brown in color
May have metallic or bitter taste in mouth
Use proper hygiene with bowel movements and cleansing

74
Q

Vancomycin

A
DOC for MRSA
Cellulitis
Bone infections
Colitis
Meningitis

Contraindications:
Pregnancy
Renal disease

PO/IV
Interactions:
Interacts with some
vitamins and herbal
products. Avoid use
when on Amikacin,
gentamicin or
streptomycin.

MoA:
It works by killing bacteria or preventing bacterial growth. Best for severe Gram + infections

Side Effects:
Dry mouth Muscles cramps
Diarrhea Nausea/vomiting
Abdominal cramping
Headache Flushing
Hypotension Tachycardia 

Adverse:
Blloody urine - Nephrotoxicity
Loss of hearing - Ototoxicity
Anaphylaxis

Interventions:
Monitor peak and trough levels.
Infuse over at least 60 minutes on an infusion pump.
Monitor BUN and Creatinine levels.
Increase fluids to 1500-2000 mL per day.
I&O, Daily weight
Baseline hearing test recommended
Education:
Teach to report headache or dizziness.
Drink adequate fluids.
Report bloody urine or dizziness, ringing in the ears or loss
of hearing
75
Q
Antihelminthics: Mebendazole (Vermox)
Ivermectin (Stromectol)
Pyrantel pamoate (Pin-X)
A
Parasites: pinworms,
tapeworms,
hookworms,
roundworms
Trichinosis
Don't use in children under 2
PO
Interactions: Effectiveness
decreased by some
anticonvulsants.
Increased absorption
with high fat meal. 

MoA: Inhibits glucose uptake and degeneration of microtubules in the cell: parasite dies and is excreted.

Advantages: Treatment is easy and usually well tolerated by all requiring medication.

Side Effects:
Diarrhea Abdominal pain
Nausea/vomiting
Dizziness Headache

Adverse:
Seizures (rare)
Intestinal blockage as parasited die

Interventions:
Entire family and close contacts must be treated to prevent reinfestation
Proper handwashing and hygiene with bowel movements
Monitor stools for presence of worms/parasites
Monitor CBC, BUN, Creatinie and liver enzymes during treatment

EDucation:
Teach proper hygiene and cleansing of clothes and
linens to prevent reinfestation.
Infected person should sleep alone until treatment
complete.
Teach to wear shoes when out doors
Teach proper cleansing of fresh fruits and vegetables

76
Q

Antivirals - HIV : Zidovudine or AZT

Retrovir

A

HIV/AIDS
Unlabeled uses:
Epstein-Barr virus
Hepatitis B

Contraindications:
Pregnancy
PO/IV/30-60mins

Interactions:
Bone marrow
depression with
antineoplastics.
Decreased platelets
and granulocytes

MoA: Inhibit viral replication and prevents synthesis of DNA of the HIV virus

Disadvantages:
Does not cure AIDS but will control symptoms: compliance with treatment required.

SIde Effects:
Nausea/vomiting Diarrhea
Anorexia Flatulence
Rash Flushing
Headache Dizziness
Dyspepsia Insomnia
ADverse Effects:
Seizures
Hepatomegaly
Anemia/Granulocytopenia
Anaphylaxis

Nursing Interventions:
Monitor Vital signs and signs of bleeding problems
Monitor CBC, BUN and creatinine closely

Education:
Teach that GI complaints and insomnia resolve after 3-4
weeks of treatment.
Report symptoms of suprainfections
Teach to not take with OTC products like Tylenol or aspirin.

77
Q

Broad Spectrum Antibiotics: Clindamycin

A

Oral/Skin Infections

Contraindications:
Pregnancy
Breast feeding
Hepatic Disease

PO/IM/IV/Topical
Interactions:
Blocked by erythromycin,
chloramphenicol.
Decreases absorption
of kaolin.

MoA: Inhibition of bacterial protein synthesis. These drugs are bacteriostatic and suppress bacterial growth.
Advatages: Can be used to treat MRSA

Side Effects:
Dry mouth Muscles cramps
Diarrhea Nausea/vomiting
Abdominal cramping
Headache Flushing
Anorexia Rash
ADverse Effects:
Pseudomembranous colitis
Stevens-Johson syndrome
Exfoliative dermatitis
Suprainfections

Interventions:
Culture before medication started for accurate results
Monitor Vital signs, urine output and stools
Monitor AST, ALT if on long term therapy
Assess for skin reactions frequently

EDucation:
Take with food to reduce GI upset
Complete entire course of medication
Take with full glass of water
Report any symptoms of suprainfections and extreme diarrhea
78
Q
Cephalosporins: 4 Generations: 
1st: cefazolin sodium
(Ancef); cephalexin
(Keflex)
2nd: cefaclor (Ceclor)
3rd: cefixime (Suprax);
ceftriaxone (Rocephin)
4th: cefepime
(Maxipime)
A

Septicemia
UTI’s
Respiratory infections
Skin/bone infections

PO/IM/IV
Interactions: 
Some interact with
alcohol. Uricosurics
increase the excretion
rate of uric acid
and can decrease
the excretion of
cephalosporins
causing serum level
increase

ADvantages: Usually well tolerated when other antibiotics cannot be administered

Disadvantages: Frequent cross hypersensitivity to penicillins

Side Effects:
Nausea/vomiting Diarrhea
Anorexia Flatulence
Rash Flushing
Headache Dizziness
Dyspepsia
Adverse Effects:
Increased bleeding
Nephrotoxicity
Seizures
Anaphylaxis
Leukopenia/Neutropenia

Interventions:
Culture the infected area before medications are started.
Monitor for adverse reactions and/or super infections

Education:
Keep drugs out of reach of children
Report sign of superinfections like mouth ulcers or
anal discharge
Advise use of probiotics when taking medications.
Take medications with food if GI upset occurs

79
Q
Fluoroquinolones: Ciprofloxacin
(Cipro,Septra)
Gatifloxacin (Tequin,
Zymar)
Levofloxacin (Levaquin)
Moxifloxacin (Avelox)
A
Common Uses:
Broad spectrum
antibiotic
Anthrax
Respiratory infections
Cystic Fibrosis

Contraindications:
Pregnancy
Infants and young
children

PO/IV/Topical
Interactions: Antacids, minerals and multivitamins
interfere with absorption.
Concurrent use with amiodarone, disopyramide. Erythromycin, some antipsychotics and tricyclic antidepressants increases risk of torsade de pointes in susceptible individuals. Concurrent use with
corticosteroids may increase risk of tendon rupture.

Side Effects:
Diarrhea Nausea/vomiting,
Abdominal pain
Dizziness Drowsiness
Sleep problems Headache
Adverse Effects:
Suprainfection Phototoxicity
Cardiotoxicity
Tendon/joint toxicity (associated with a small risk of
tendon rupture

Interventions:
Monitor I&O
Monitor BUN and creatinine levels
Store medication away from heat, moisture, and direct sunlight

CLient Education:
Take with a full glass of water. Do not take on an empty stomach.
Notify primary healthcare provider of swelling of the face and
throat, swallowing problems, shortness of breath, rapid heartbeat,
tingling of fingers or toes, itching or hives.
Stop taking the medicine immediately if swelling in tendon occurs.
Avoid being in direct sunlight and use a sunscreen; do not use
tanning beds.
Do not take antacids that contain aluminum, calcium or magnesium

80
Q

Macrolides: Azithromycin (Z-Pak,

Zithromax) Clarithromycin (Biaxin) Erythromycin (Erythrocin)

A
Broad-spectrum
Antibiotic for
Pneumonia, pertussis,
diphtheria, chlamydia,
Group A strep
infections. 
Interactions: 
Increases the plasma levels of
theophylline, carbamazepine,
and warfarin. Conversely,
plasma levels of erythromycin
can be reduced when used
with verapamil, diltiazem,
HIV protease inhibitors
and azole antifungal
drugs. Contraindicated
with astemizole, cisapride,
pimozide or terfenadine.

MoA: Inhibition of bacterial protein synthesis. These drugs are bacteriostatic and suppress bacterial growth and replication but do not cause microbial death.

Advantages: Good alternative for clients with penicillin
allergies

Side Effects:
Nausea/vomiting
Diarrhea
Abdominal pain

Adverse Effects:
Suprainfections Hepatotoxicity
Dysrhythmias (prolonged Q-T interval)
Ototoxicity Anaphylaxis
Pseudomembranous colitis

Interventions:
Administer on an empty stomach -destroyed by gastric acids and acidic fruit juice.

Education:
Notify primary health care provider if prolonged diarrhea
occurs.
For capsule administration, take 1-2 hours before meals.
Direct sunlight (UV) exposure should be minimized during
therapy.

81
Q

Non-HIV Antivirals : Rimantacine HCL (Flumadine) Oseltamivir phosophate (Tamiflu)
Acyclovir (Zovirax)

A

Influenza
Herpes viruses
Cytomegalovirus (CMV)

PO/IV
Interactions: Decreases effect of
phenytoin. Increases
nephro-neurotoxicity
with aminoglycosides,
probenecid and interferon.

MoA: Inhibit viral replication by interferring with viral cell synthesis

Disadvantages: Cannot stop the viral infection but will
reduce the severity of symtoms and length of infection.

Side Effects: 
Nausea/vomiting Anorexia
Diarrhea Headache
Agitation Lethargy
Rash Pruritis
Adverse: 
Anemia
Crystalluria
Nephrotoxicity
Thrombocytopenia
Leukopenia

Interventions:
Monitor Vital signs and urine output closely
Monitor CBC, BUN, creatinine and liver enzymes
Increase fluid intake to 1500-2000 mL per day
Assess gums for bleeding

EDucation:
Teach proper hydration while taking medications
Report changes in urine output or signs of bleeding
Report CNS changes and safety related to orthostatic
hypotension

82
Q
Penicillin: Ampicillin (Principen),
Amoxicillin (Amoxil, Trimox),
Penicillin G (Bicillin), Penicillin V
(PenVK), Ampicillin/Sulbactam
(Unasyn), Amoxicillin/
Clavulanate (Augmentin),
Ticarcillin (Ticar), Peperacillin/
Tazobactam (Zosyn)
A
Used in: Meningitis
Gram (+) infections
Respiratory infections
Endocarditis
Septicemia
Otitis media
GI infections
GU infections

Interactions; Give separately
from aminoglycosides: May inactivate medication

Side Effects:
Mild rash
Nausea/vomiting
Diarrhea
Stomatitis
Vaginitis 
Adverse Effects: 
Anaphylaxis
Glomerulonephritis
Bone marrow depression
Leukopenia

Interventions:
Administer with water, not acidic juices.
Administer around the clock on empty stomach for better absorption.
I&O
Monitor CBC

EDucation: Take medication with plenty of water 1-2 hours before meals or 2-3 hours after meals).
Report sore throat, fever, fatigue, diarrhea as they may
indicate superinfection

83
Q

Sulfonamides: Trimethoprim/
Sulfamethoxazole
(Bactrim, Septra)
Sulfisoxazole (Gantrisin)

A
UTI’s
Ear infections
Newborn eye
prophylaxis
Respiratory
infections
PO/IV/topical 
Interactions: Risk of
thrombocytopenia
with thiazide diuretics;
hyperkalemia with
other diuretics

MoA: Bacteriostatic - inhibit bacterial synthesis of folic acid which is essential for bacterial growth.
Advantages: Good for client with penicillin allergy

Side Effects:
Nausea/vomiting Diarrhea
Anorexia Crystalluria
Rash Flushing
Headache Dizziness
Dyspepsia Photosensitivity
Adverse Effects:
Nephrotoxicity
Hyperkalemia
Stevens-Johnson syndrome
Anaphylaxis

Nursing interventions:
Increase fluids to 2000-3000 mL per day
Assess I&O, BUN and creatinine regularly
Monitor Vital signs closely
Assess for early signs of anemia or superinfections

Education:
Drink lots of fluid daily when taking medications
Take 1 hour before or 2 hours after meals
Wear sunglasses and avoid direct sunlight
Report any excess bruising or bleeding

84
Q

Tetracyclines :
Doxycycline (Vibramycin)
Tetracycline (Sumycin)

A

Broad spectrum use
Respiratory infections
Skin infections
STD/STI’s

Contraindicated in Pregnancy and Hepatic disease

Interactions: Do not take with antacids or calcium products

Side Effects: 
Nausea/vomiting
Diarrhea
Abdominal pain
Stains teeth
Color vision changes

Adverse:

Nephrotoxicity
Hepatotoxicity
Suprainfections
Anaphylaxis
Severe Photosensitivity
Hyperglycemia

Interventions:
Monitor Vital signs and urine output closely
Monitor liver and renal function lab tests
Avoid antacids and calcium products when taking medication

EDucation:
Teach whether medication prescribed should be taken
with food or without and time frame for best absorption.
Avoid sun and use sunglasses/WEAR LONG SLEEVES
Do not take with milk products, iron or antacids
Take liquid forms via straw to prevent staining of teeth
Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline. Absorption will be altered. For instance, iron can bind to doxycycline in the gastrointestinal tract, which may prevent their absorption into the bloodstream and possibly reduce their effectiveness. To avoid or minimize the interaction, iron containing medications and doxycycline should preferably be taken at least three hours apart in most cases.
Take on an empty stomach to maximize absorption, although may not be tolerated unless administered with food.

85
Q

Antiviral Monoclonal Antibody : Palivizumab (Synagis) RSV Immune globin (RespiGam)

A
Prevents RSV in
premature infants
and infants born with
certain lung disorders
or heart disease.

Contraindications:
Bleeding or clotting
disorders
Low platelet count

IM
MoA: A man-made antibody to respiratory syncytial virus (RSV).

Side Effects: 
Fever
Crying or fussiness
Change in appetite or sleeping
patterns

Adverse Effects:
Cyanosis
Black tarry stools
Bleeding gums

Interventions:
Dosage is based on weight of infant and must be calculated with
every dose

Education:
Must take it monthly during the RSV season – November
through April
Local reactions may occur to injection: tenderness, hives and
swelling
May interfere with other live vaccines and may need to
revaccinated if taken with 10 months after completed

86
Q

Biologic: adalimumab

Humira

A

Crohn’s disease,
Psoriatic arthritis
Rheumatoid arthritis

Sub Q
Interactions: Anakinra (Kineret) also used
to treat rheumatoid arthritis, vaccines

MoA: Biologics work by targeting and blocking the effects of a protein in your body called TNF – alpha. In autoimmune disorders, there
is too much of this protein which can cause the body to attack itself. In rheumatoid arthritis, too much of this protein can cause pain, stiffness and swelling in the joints. In ulcerative colitis or Crohn’s, adalimumab can decrease the symptoms and put the client
in remission

Advantages: Provide very specific targeting of the involved cells

Disadvantages: Expensive and not always covered by
insurance. Significant adverse symptoms.

Side Effects: 
Headache
Nausea
Sinus infections
Rash at the injection site

Adverse Effects:
Cancers
Sepsis
Fungus and other opportunistic infections

Interventions:
Check for injection site reactions.
Assess for TB prior to therapy
Assess for blood dyscrasias: CBC, differential periodically

Education:
Learn proper administration of med in the thigh, abdomen
and upper arm
Rotate sites at least one inch from old site.
Advise no vaccines
Report signs of infection immediately

87
Q

Immune Serum : Tetanus Immune

Globulin (Baytet)

A

Exposure to tetanus
IM/ 2 days
Interactions: These vaccines may not work
as well if received shortly after a tetanus injection: Measles, mumps, rubella
(MMR), poli

MoA: Tetanus immune globulin works by giving your body the antibodies it needs to protect it against tetanus infection. This is
called passive protection. This passive protection lasts long enough to protect your body until your body can produce its own
antibodies against tetanus.

Side Effects:
Itching
Redness at injection site
Anorexia
Mild fever
Pain at injection site
Adverse Effects:
Facial edema
Difficulty swallowing
Tightness of chest
Dyspnea

Interventions
Monitor for signs of significant reaction (eg, wheezing; chest
tightness; fever; itching; bad cough; blue skin color; seizures;
or swelling of face, lips, tongue, or throat).

Education:
Reason for medication
Educate client about signs of a significant reaction (eg, wheezing;
chest tightness; fever; itching; bad cough; blue skin color; seizures;
or swelling of face, lips, tongue, or throat).

88
Q

Immune System Agents/ Immunosuppressant/ Anti-rejection: tacrolimus (Prograf) cyclosporine
(Sandimmune

A

Autoimmune
diseases
Prevent organ
transplant rejection

Contraindications: Hypersensitivity
Use cautiously in:
Diabetes, HTN
Hyperkalemia
Hyperuricemia 
PO/IV
Interactions:
Aminoglycosides: increased
toxicity
Antifungals and calcium
channel blockers: increase
blood levels
Vaccines decrease effect
Side Effects:
Insomnia Back pain
Fever UTI’s
Nausea/vomiting
Muscle spasms
Adverse Effects: 
Infection
Hypertension
Hepatotoxicity
Nephrotoxicity
Pulmonary edema

Interventions:
Monitor liver functions test: AST, ALT, amylase, and bilirubin
Monitor serum creatinine and BUN and output - 75% of patients will
experience a decrease in urinary output
Watch for anaphylaxis
Monitor blood studies

Education:
Advise to report if pregnancy is planned
Report fever, rash, severe diarrhea, chills, sore throat,
because serious infections can occur.
Report clay colored tools or cramping as it may indicate
hepatotoxicity.
Avoid crowds or persons who are sick to reduce infections.
Avoid eating raw shellfish.

89
Q

Vaccines - Biologic Response Modifiers (BRMs) : Hepatitis B recombinant viral antigen

HPV recombinant
viral antigen

A

Prevention of Hepatitis
B which can lead to liver
cancer.

Prevention of cervical, anal,
oropharyngeal cancers;
genital warts

MoA:
Hepatitis B vaccine recombinant is used to prevent infection by the hepatitis B virus. The vaccine works by causing your body
to produce its own protection (antibodies) against the disease. It cannot give you the hepatitis B virus (HBV) or the human
immunodeficiency virus (HIV).

HPV: When a client receives the vaccine, the immune system produces antibodies against these proteins so if the body ever
encounters them again in the form of the actual HPV virus it is well equipped to deal with and destroy the virus.

Advantages:
HPV: Available for both men and women ages
9-26 years of age.

HepB : : Does not treat Hep B

Intervention: Observe client for s/s of adverse reaction to vaccines.
Keep epinephrine readily available for immediate use in case of anaphylactic
reaction.
Provide client with record of immunizations received.

Education:
Discuss vaccine-preventable diseases
Answer questions regarding vaccine safety and efficacy
Advise female clients of childbearing age to avoid
pregnancy for 1 month.
Provide Vaccine Information Statements from CDC

90
Q

Vaccines and Toxoids:

Tetanus Toxoid

A

Prevention of tetanus

Contraindications:
Hypersensitivity
Active infection
Poliomyelitis outbreak
Immunosuppression
Febrile illness

SubQ/IM/2 weeks

Interactions: 
Increased
immunosuppression
if given with warfarin,
corticosteroids, or
cancer chemotherapy
drugs 

MoA: Vaccines work by causing the body to produce its own protection (antibodies). Tetanus vaccine is usually first given to infants with 2 other vaccines for diphtheria and whooping cough (pertussis) in a series of 3 injections. This medication is usually used as a “booster” vaccine after this first series. Booster injections may be needed at the time of injury in older children and adults if it has been 5-10 years since the last
tetanus vaccine was received. Booster injections should also be given every 10 years even if no injury has occurred.

Disadvantages: Do not use the vaccine on children younger
than 7 years if it has the preservative thimerosal in it, as this may contain mercury

Side Effects:
Mild fever
Joint pain
Muscle aches
Nausea
Tiredness
Pain/itching/redness at injection site
Adverse Effects: 
Tingling of hands/feet
Hearing problems
Trouble swallowing
Muscle weakness
Seizures
Swelling of face/tongue

Interventions:
Have epinephrine infection (1:1,000) readily available should an acute
anaphylactic reaction occur.
Monitor for signs of anaphylactic reaction.
Record the date, lot number and manufacturer of the vaccine on the
immunization record

Education:
Make sure the client/parents were fully informed of benefits
and risks of immunization by the PHCP.
Provide a copy of the immunization record with the date, lot
number and manufacturer of the vaccine listed.

91
Q

Antitubercular agent: Rifapentine

A

Rifapentine (Priftin), a derivative of rifampin, is an antitubercular agent used with other drugs (eg, isoniazid) as a combination therapy in active and latent tuberculosis infections. Both rifampin and rifapentine reduce the efficacy of oral contraceptives by increasing their metabolism; therefore, this client will need an alternate birth control plan (non-hormonal) to prevent pregnancy during treatment

Clients taking rifampin or rifapentine (Priftin) as part of antitubercular combination therapy should be taught to prevent pregnancy with non-hormonal contraceptives, notify the health care provider of any signs or symptoms of hepatotoxicity (eg, jaundice, fatigue, weakness, nausea, anorexia), and expect red-orange-colored body secretions.