Infection Flashcards
If the trough concentration is too high what action do we take?
Increase interval doses
If the peak concentration is to high, what action do we take?
Decrease the dose
For multi dose regimen, what should the PEAK concentration be and what should the TROUGH concentration be for gentamicin?
5-10mg/L for Peak
<2 mg/L for trough
Endocarditis: Peak=3-5 and Trough= <1
CF in children: Peak= 8-12 and Trough= <2
If someone is allergic to penicillin, what other class of antibiotic have they got to use in caution?
Cephalosporins
What is 1st line for otitis externa?
What is the alternative if someone is allergic to the 1st line?
Flucloxacillin
Clarithromycin, erythromycin, azithromycin
What is 1st line for bacterial vaginosis?
400–500 mg twice daily for 5–7 days, alternatively 2 g for 1 dose
What is the antibiotic used for the 1st mild episode of C.Diff?
Metronidazole
What is 2nd line for C.Diff if it doesn’t respond to 1st line or infection is severe? and what can be added if a person doesn’t respond to 2nd line and its life threatening?
Oral Vancomycin
add iv metronidazole
Which antimalarial should be avoided if pt has a history of or is experiencing psychiatric conditions?
Mefloquine: Mefloquine is associated with potentially serious neuropsychiatric reactions. Abnormal dreams, insomnia, anxiety, and depression occur commonly.
Which anti malarial is safe in pregnancy?
Chloroquine & proguanil hydrochloride
What is oral 1st line antibacterial for impetigo?
Flucloxacillin
What are the major risks of quinolones? Theres 4
Tendon issues (rupture rarely)
Aortic aneurism
Long last and possibly irreversible S/E
Can increase risk of convulsions if pt takes NSAIDs or has a history of epilepsy
What is 1st line antibacterial for Cellulitis
Flucloxacillin
