Infection

Question 0

Lymphocytes of innate immunity

Answer 0

Natural killer (NK) cells

Question 1

1st line of defense from pathogens

Answer 1

Physical barriers: skin, stomach acid, lysozyme, etc.

Question 2

Lymphocytes of specific adaptive immunity

Answer 2

T cells & B cells

Question 3

2 kinds T lymphocytes

Answer 3

1) cytotoxic T cells (CD8+)

2) T helper cells (CD4+)

Question 4

T cells need ______ to bind to antigen.

Answer 4

MHC (major histocompatability complex), on surface of cell,

Question 5

cytotoxic T cells MOA

Answer 5

locate & lyse abnormal cells

Question 6

T helper cells MOA

Answer 6

secrete cytokines for clonal expansion T & B lymphocytes

Question 7

_____ cells respond to soluble antigens and present them to _____ cells.

Answer 7

B cells respond and present antigens to T cells

Question 8

Sterile sites include:

Answer 8

urine, blood, peritoneal space, central nervous system

Question 9

Non-sterile sites include:

Answer 9

GI tract, skin, vagina, mucosal membranes

Question 10

Classes microorganisms responsible for infection:

Answer 10

bacteria, virus, fungi & parasite

Question 11

Are bacteria prokaryotes or eukaryotes?

Answer 11

PROKARYOTES

Question 12

SIRS criteria:

Answer 12

1) WBC abnormality (>12,000 or 38.3 or 90

4) RR >20 or PCO2<32

Question 13

How many SIRS criteria must meet to qualify as SIRS:

Answer 13

2 or more!

Question 14

Sepsis

Answer 14

infection source + SIRS

Question 15

Severe sepsis =

Answer 15

Sepsis + Sepsis-induced organ dysfunction/tissue hypoperfusion

Question 16

Septic Shock =

Answer 16

severe sepsis + hypotension not relieved by IV fluids

Question 17

If patient in severe sepsis, must administer…

Answer 17

vasopressors!