Infection

Question 1

Flucloxacillin

Answer 1

• Beta lactam, inhibiting cell wall synthesis
• Used against staph aureus and strep
• Used to treat skin, wound and bone infections

SE - nausea and vomiting

Question 2

co-amoxiclav

Answer 2

• Combination of clavulanic acid and amoxicillin (beta lactamase inhibitor and beta lactam)
• Beta lactase inhibits beta lactam ring, preventing resistance to amoxicillin

Used for - Treating UTI’s, skin infections, respiratory tract infections, bone and joint infections…
- against staph and e coli

SE - Most common include thrush, diarrhoea, nausea

Question 3

Vancomycin

Answer 3

• Glycopeptide and so acts on the cell wall, preventing making of peptidoglycan chains, inhibiting cross linking
• Bacterial cell wall is made of glycan strands that link together
• Used against - Clostridium difficle infection of the intestines (gram positive bacteria)

SE - Nausea

Question 4

Ceftriaxone

Answer 4

• Inhibits cell wall synthesis by binding to transpeptidase which are penicillin binding proteins (selective and irreversible)
• 1st line meningitis treatment

SE - can cause clostridium difficle infection, nausea and Gi irritations…

Question 5

Doxycycline

Answer 5

• Tetracycline drug, reduces bacterial ribosomes and so reduces protein synthesis, binding to Ca and Mg ions
• used for skin, chest and STI medication

SE - Can stain teeth, nausea, rashes, GI irritations

• Not used during pregnancy due to inhibition of folic acid synthesis (teratogenic)