Induction Agents & Sedatives Flashcards
How is propofol excreted?
Kidneys
How is propofol biotransformed (metabolized)?
Liver conjugation into inactive metabolites
How is propofol distributed?
Highly lipid soluble
Very rapid redistribution
Very quickly goes to the VRG which includes the brain which is why pts fall asleep so quickly then in a relatively short period of time it redistributes from the VRG into the peripheral compartment which includes the muscle and fat compartments.
What is propofol’s mechanism of action?
It enhances inhibitory transmission thru GABA receptors
What does propofol contain in its vial?
Its an emulsion in intralipid (a fatty substance made out of soybean oil, glycerol, egg lecithin)
—————Lecithin is from yolk, most allergies are to egg white (protein)
—————-Patients with soy allergy or egg allergy can receive propofol without any special precautions.
The intralipid is significant bc it supports bacterial (and fungal) growth – use aseptic technique
—————–Discard contents of opened vial and propofol tubing after 12 (6?) hours
Can pts with egg allergy receive propofol?
Yes, bc most people allergic to egg are allergic to egg white while propofol’s egg content is from egg yolk.
Why is the intralipid emulsion in which propofol is stored siginificant?
The intralipid is significant bc it supports bacterial (and fungal) growth – use aseptic technique
—————–Discard contents of opened vial and propofol tubing after 12 (6?) hours
How long after opening a vial of propofol do we use it?
Discard contents of opened vial and propofol tubing after 12 (6?) hours
Are there any issues with giving propfol to pts with moderate cirrhosis?
No bc it doesnt seem to slow down or have any effect on propofol’s metabolism
Is there any issue with giving propofol to patients with chronic renal failure?
No bc propofol is metabolized into inactive metabolites and enters the kidney this way and has not problems being excreted from the body despite the chronic renal failure
Induction dose of propofol
Dose: 1.5 – 2.5 mg/kg in adults
Dose: 1 mg/kg in elderly
Propofol infusion for sedation
25-75 mcg/kg/min
Propofol infusion for general anesthesia
100-200 mcg/kg/min
– the target plasma concentration = 4-6 mcg/mL
- There is some risk of awareness when used as the sole agent
- Higher incidence of movement when used as sole agent (seems to work best when used together with an inhalant, opioid, or ketamine.)
Propofol’s effect on the CV System:
- Significant ↓↓ SVR (lots of vasodilation & hypotension)
- ↓contractility,
- ↓preload → hypotension
Decrease in BP is mosre pronounces with rapid injection, old age, LV failure
Potential for bradycardia, but often tachycardia with induction
Propofol’s effect on the Respiratory System:
- Profound respiratory depression & apnea
- depresses hypoxic/hypercapnic drives
- Profound depression of upper airway reflexes
Acceptable to use with Asthmatics – less wheezing using propofol than with thiopental
Propofol’s effect on the Neuro system:
↓ CBF (cerebral blood flow) ↓ ICP (intracranial pressure) ↓ CMRO2 (cerebral metabolic rate) - Anti-emetic (useful for pts with N&V) - Anti-epileptic - On induction -> may see myoclonic twitches, hiccupping - On emergence -> may experience euphoria, intense dreaming, amorous behavior - Potential for abuse and addiction --------Little evidence of tolerance
Why does propofol burn when you inject it into a peripheral IV?
—– Most people think the burning is caused by the intralipid solvent (and propofol itself) –> produces bradykinin —-> which vasodilates, increases contact between the aqueous phase of propofol (phenol is irritating) and the free nerve endings.
How can you minimize the burning caused by propofol injection?
- Lidocaine + tourniquet (Bier block)
- Pre-treat with IV opioid
- Mixing propofol with lidocaine (to acidify the propofol emulsion and make it less likely to cause burning)
- Lidocaine also inhibits bradykinin - since bradykinin causes the burning this may be the mechanism for reducing burning sensation but unclear
Acute Hypertriglyceridemia =
An effect caused by the high-fat content of propofol and propofol’s inhibition of fatty acid oxidation
When prolonged high dose propofol infusions make the blood super fatty
Treatment:
- stop propofol infusion,
- give insulin/dextrose to promote lipoprotein lipase activity
Propofol infusion syndrome
- Presents as:
Hyperlipidemia, rhabdomyolysis, metabolic acidosis, refractory bradycardia, progresses to circulatory collapse, death - Typically occurs as an “all or none” syndrome with sudden onset and high incidence of death
- Typically seen in ICU pts who have been on prolonged high-dose infusions
Ex: ( >75 mcg/kg/min, for more than 24 hours) - Usually seen in critically ill patients, especially on vasopressors
- May reflect a genetic susceptibility
- Both the intralipid lipid solvent and propofol itself contribute to the development of hyperlipidemia and hypertriglyceridemia, but the pathogenesis is not well understood
Barbiturates include drugs like…
Phenobarbital, methohexital, thiopental, thiamylal, secobarbital
Barbiturate mechanism of action =
They depress the brain stem’s Reticular Activating System (consciousness center)
They suppress certain excitatory neurotransmitters = Acetylcholine
They enhance certain inhibitory neurotransmitters = γ-aminobutyric acid, GABA
Barbiturate solubility
Water-soluble
but the preparation is very alkaline (pH >10) and unstable (which makes is last only 2-6 weeks in refrigerator)
Barbiturate acidity
- Weak acid with pKa close to 7.4
- Pain with extravasation, but usually painless on injection
