induction agents

Question 1

induction dose of propofol (Diprivan)

Answer 1

1-2 mg/kg

Question 2

propofol MOA

Answer 2

GABA-A agonist - causes opening of Cl- channel

Question 3

induction dose of etomidate (Amidate)

Answer 3

0.3 mg/kg

Question 4

etomidate is good for what patients?

Answer 4

cardiac patients and pts with high ICP

from ARMC review

Question 5

etomidate MOA

Answer 5

GABA-A agonist - causes opening of Cl- channel

Question 6

induction dose of methohexital (Brevital)

Answer 6

1-1.5 mg/kg

Question 7

MOA of methohexital

Answer 7

barbituate - depresses CNS via potentiating GABA

Question 8

what is important to rmbr about methohexital?

Answer 8

LOWERS seizure threshold, so easier for a pt to have a seizure

Question 9

induction dose of ketamine (Ketalar)

Answer 9

1-2 mg/kg IV
or
3-4 mg/kg IM

Question 10

main MOA of ketamine

Answer 10

main: NMDA antagonist
other: opioid agonist so provides analgesia (unlike propofol and etomidate!)

it’s a phencyclidine (PCP) derivative

Question 11

what is a key difference of ketamine from other induction agents?

Answer 11

does not cause HoTN and apnea b/c it resembles SNS stimulation = increases SBP, HR, CO, PAP, MRO2