Individual Chemo Flashcards
Alkylating Agent Chemo’s
Cell cycle NON-SPECIFIC Cisplatin Oxaliplatin Carboplatin BEndamustine Cyclophosphamide Ifosphamide Melphalan BEndamustine Busulfan Thitepa
Antimetabolites- Antifolates chemo names
Methotrexate
Premetrexed
Pralatrexate
5-Fluropyrimidines chemo names
Cell cell SPECIFIC
Flurouracil
Capecitabine
Flourdine
Cytosine Analogues names
Cell cycle SPECIFIC Azacitidine (Vidaza) Decitabine Cytarabine (ara-C) Fludarabine Gemcitabine
Anthracyline and Antitumor antibiotic names
Cell cycle SPECIFIC Doxorubicin Epirubicin Idarubicin Mitoxantron Belong in Vixeos (liposomal daunorubicin and cytarabine)
antimicrotubule chemo names
Vincristine Vinblastine Binorelbine Vindesine Paclitaxel Docetaxel Ixabepilone Eribulin
Topoisomerase Inhibitor names
Cell cycle SPECIFIC
Irinotecan
Toptecan
Etoposide (VP-16)
Nitrosureas names
Cell cycle NON-SPECIFIC
Cross blood brain barrier
Carmustine
Lou stone
STreptozocin
Cisplatin side effects
Ototoxicity
Renal toxicity
Oxaliplatin side effects
Cold neuropathy
Carboplatin side effects
Hypersensitivity reaction (7th dose) - may see itching, palms/feet
Cyclophosphamide and Ifosfamide side effects
Hemorrhagic cystitis - used Mensa (usually equal dose)
Methotrexate side effects
Renal toxicity
High dose - requires leucovorin rescue
Pralatrexate side effects
Need to administer folic acid, steroids and B12
Flurouracil side effects
Angina
Capecitabine side effects
Hand-foot syndrome
Azacitidine side effects
(Vidaza)
CHF
Decitabine side effects
TLS
Cytarabine side effects
Cerebellar toxicity
High dose - conjunctivitis (use steroid eye drops)
Neurotoxicity
Fludarabine side effects
TLS
Gemcitabine side effects
Pulmonary toxicity
Doxorubicin/Daunorubicin side effects
Cell cycle SPECIFIC
Lifetime cumulative dose
Radiation recall of XRT dermatitis
Red urine
Liposomal doxorubicin side effects
Hand foot syndrome
Epirubicin/Idarubicin side effects
Red urine
Mitoxantrone side effects
Blue urine and sclera
Bleomycin side effects
Pulmonary fibrosis
Vyxeos (liposomal daunorubicin and cytarabine) side effects
Myelosupression
Cardiotoxicity
Hypersensitivity
Copper overload
Vincristine side effects
Cell cycle SPECIFIC
FATAL if intrathecal
Constipation
Paclitaxel/Docetaxel side effects
Cell cycle SPECIFIC
Vesicant
Anaphylactic reactions (can be severe)
Myalgia
Irintoecan Side effects
Cell cycle specific
Diarrhea (early and late)
Give atropine for early onset
Give Imodium for late diarrhea
Etoposide side effects
Cell cycle specific
Hypotension - give over 60 min
Asparaginase side-effects
Anaphylactic reactions Hepatotoxicity Coagulopathy Pancreatitis Cell cycle NON-SPECIFIC
Treninoin (ATRA) and Arsenic side-effects
QT prolongation - could lead to Torsades
Electrolyte imbalance
Cough and dyspnea (retinoids acid syndrome)
–white cells go to lungs - manage with steroids
Hydrea side effects
bone marrow depression
Mucositis
Secondary malignancy
Carmustine side effects
Cross blood brain barrier
Part of BEAM regimen for lymphoma
Pulmonary fibrosis
STreptozocin side effects
Renal toxicity
Bone marrow depression
Hyperglycemia
