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Certificate of Specialty Pharmacy > Indication and dosing > Flashcards

Indication and dosing Flashcards

1
Q

Humira dose on RA/PsA/AS

A

400mg every 2 weeks

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2
Q

Humira dosing on Uveitis/PP/HS

A

80mg then 40mg every 2 weeks, beginning 1 week after initial dose

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3
Q

Humira dosing on HS

A

160mg on day 1 then 80mg on day 15 then 40mg weekly or 80mg every 2 weeks on day 29

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4
Q

Humira dosing on CD/UC

A

160mg day 1 then 80mg on day 15 then 40mg every 2 weeks beginning on day 29

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5
Q

Enbrel dosing on RA/PsA/AS

A

50mg weekly

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6
Q

Enbrel dosing on PP

A

50mg twice weekly for 3 months then 50mg weekly

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7
Q

Cimzia dosing on RA/AS/nr-axSpA/PsA

A

400mg weeks 0, 2, 4 then 400mg ever 4 weeks or 200mg every 2 weeks

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8
Q

Cimzia dosing on PP

A

400mg every 2 weeks (<90kg - 400mg week 0, 2, 4 then 200mg every 2 weeks)

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9
Q

Cimzia dosing on CD

A

400mg week 0, 2, 4 then 400mg every 4 weeks

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10
Q

Simponi dosing on RA/PsA/AS

A

50mg monthly (IV - 2mg/kg at week 0, 4, then every 8 weeks); for RA - with MTX

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11
Q

Simponi dosing on UC

A

200mg week 0 then 100mg week 2 then 100mg every 4 weeks

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12
Q

Remicade dosing on RA

A

3mg/kg at 0, 2 and 6 weeks then 3mg/kg q 8 weeks

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13
Q

Anakinra (Kineret) indication and dose

A

RA - 100mg SC QD

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14
Q

Rilonacept (Arcalyst) indication and dose

A

CAPS and recurrent peri-carditis - 320mg SC followed by 160mg weekly beginning 1 week later (>12 yo)

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15
Q

Canakinumab (Ilaris) indication and dose

A

CAPS, FMF, HIDS, MKD, TRAPS - 150mg SC every 8 weeks;

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16
Q

Dupilumab (Dupixent) indication and dose

A

AD, Prurigo Nodularis: 600mg initially then 300mg every other week
EOE: 300mg once weekly
note PFS approved for >6 months; Pen for >2yo

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17
Q

Tocilizumab (Actemra) indication and dose

A

RA - SC - <100kg - 162mg every other week; >100kg - 162mg weekly; (IV 4-8mg/kg every 4 weeks)
GCA, ILD - 162mg SC weekly

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18
Q

Sarilumab (Kevzara) indication and dose

A

RA and Polymaylaiga Rheumatica - 200mg SC every 2 weeks

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19
Q

Tralokinumab (Adbry) indication and dose

A

AD - 600mg (4x150mg) initially then 300mg (2x150mg) every other week (<100kg pt - can consider 300mg every 4 weeks for clear skin after 16wks of tx)

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20
Q

Secukinumab (Cosentyx) indication and dose

A

PP - 300mg q wk for 5 weeks then 300mg every month
PsA/AS/nr-axSpA - 150mg q wk for 5 weeks then 150mg every month (LD is optional) - can increase to 300mg every 4 weeks

21
Q

Ixekizumab (Taltz) indication and dose

A

AS/PsA - 160mg once then 80mg every 4 weeks
PP - 160mg once then 80mg week 2, 4, 6, 8, 10, 12 then 80mg every 8 weeks
nr-axSpA - 80mg every 4 weeks (no LD)

22
Q

Brodalumab (Siliq) - indication and dose

A

PP - 210mg SC week 0, 1, 2 and then 210mg every 2 weeks

23
Q

Ustekinumab (Stelara) - indication and dose

A

PP - <100kg - 45mg at week 0, 4, then every 12 weeks
>100kg - 90mg at week 0, 4, then every 12 weeks
PsA - 45mg at week 0, 4, then every 12 weeks
CD/UC - Induction IV then maintenance 90mg every 8 weeks begin 8 weeks after IV induction (single dose)

24
Q

Tildrakizumab (Ilumya) - indication and dose

A

PP - 100mg week 0, 4, and q 12 weeks

25
Q

Risankizumab (Skyrizi) - indication and dose

A

PsA and PP- 150mg at week 0, 4 and every 12 weeks
CD - IV 600mg at week 0, 4, 8 then SC 180mg to 360mg SC at week 12 then every 8 weeks thereafter (Check liver enzyme and bilirubin before starting)

26
Q

Guselkumab (Tremfya) - indication and dose

A

PsA and PP - 100mg week 0, 4, then every 8 wks

27
Q

Spesolimab (Spevigo) - indication and dose

A

GPP (Generalized Pustular Psoriasis) - 900mg IV once if flare persists, additional 900mg may be given 1 wk later

28
Q

Tofacitinib (Xeljanz) - indication and dose

A

RA, AS, PsA - 5mg BID or 11mg XR QD
UC - IR induction 10mg BID x 8 wks then 5mg or 10mg BID
or XR induction - 22mg dailyx8 wks then 11 or 22mg daily

29
Q

Baricitinib (Olumiant) - indication and dose

A

RA - 2mg daily
AA - 2mg daily may increase to 4mg if inadequate response

30
Q

Upadacitinib (Rinvoq) - indication and dose

A

RA, PsA, AD, AS, NraxSPA - 15mg daily (may increase to 30mg in AD)
UC and CD - 45mg daily for 8 to 12 wk then 15mg daily (may consider 30mg daily for extensive disease)

31
Q

Abrocitinib (Cinbiqo) - indication and dose

A

AD- 100mg daily (if insufficient response after 12 weeks may increase to 200mg daily; start at 50mg if poor CYP2C19 metabolizer)

32
Q

Ritlecitinib (Litfulo) - indication and dose

A

AA - >12 yo - 50mg po QD

33
Q

Ruxolitinib (Opzelura) - indication and dose

A

AD - apply BID (should not exceed 20% BSA, reassess Tx if s/s not resolved within 8 weeks)

34
Q

Deucravacitinib (Sotyktu) - indication and dose

A

PP - 6mg po daily

35
Q

Abatacept (Orencia) - indication and dose

A

RA, PsA - 125mg SC weekly (+/- IV LD)

36
Q

Apremilast (Otezla) - indication and dose

A

Bechets disease, PP, PsA - titration to 30mg BID starting with 10mg QAM

37
Q

Belimumab (Benlysta) - indication and dose

A

SLE - IV 10mg/kg every 2 weeks x3 doses then 10mg/kg q 4 weeks
SC 200mg once weekly
(if switching from IV to SC - give SC dose 1-4 wks after last IV)
Lupus Nephritis - IV - same with SLE
SC - 400mg every week for 4 doses then 200mg every week thereafter

38
Q

Vedolizumab (Entyvio)- indication and dose

A

CD/UC - 300mg IV at week 0, 2, and 6 then every 8 weeks

39
Q

Natalizumab (Tysabri) indication and dose

A

CD - 300mg IV every 4 weeks

40
Q

Rituximab (Rituxan) - indication and dose

A

RA - 1000mg IV days 1 and 15, then 1000mg every 16 to 24 weeks (Combo with MTX)
Remphigus Vulgaris - 1000mg every 2 weks for 2 doses (in combo with glucocorticoids tapering) followed by maintenance of 500mg at months 12 and 18 and every 6 months

41
Q

Pegloticase (Krystexxa) - indication and dose

A

Gout - 8 mg IV every 2 weeks (With MTX)

42
Q

Omalizumab (Xolair)- indication and dose

A

Chronic idiopathic urticaria - 150mg or 300mg every 4 weeks

43
Q

Methotrexate- indication and dose

A

RA and PP - 7.5mg - 25mg every week

44
Q

Teduglutide (Gattex) - indication and dose

A

SBS (Short bowel syndrome) - 0.05mg/kg SC once daily

45
Q

Ozanimod (Zeposia) - indication and dose

A

UC - titration from 0.23mg once daily to 0.92mg once daily starting on day 8 (if missed dose at first 2 weeks, reinititate titration with 0.23mg once daily)

46
Q

Anifrolumab (Saphnelo) - indication and dose

A

SLE - 300mg IV every 4 weeks

47
Q

Voclosporin (Lupkynis) - indication and dose

A

Lupus Nephritis - adjust dose with renal and hepatic impairment:
Initial 23.7mg (3 capsules) BID +CS +MMF

48
Q

Avacopan (Tavenos) - indication and dose

A

ANCA associated vasculitis (Adjunctive agent) - 30mg (3 capsules) po BID

Certificate of Specialty Pharmacy (3 decks)

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