Inclusions/Protein Aggregates Flashcards

1
Q

Alzheimer’s Disease (3)

A

Neuritic Plaques (silver, thioflavin S, APP/AB)
Neurofibrillary Tangles/Neuropil threads (silver, phospho-tau)
Cerebral amyloid angiopathy (thioflavin S, APP/AB)

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2
Q

Neuritic Plaques (+stains, 3)

A

Silver (Bielschowsky)
Thioflavin-S
APP/AB

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3
Q

Neurofibrillary Tangles/Neuropil Threads (+stains, 2)

A

Silver (Bielschowsky)
Phospho-tau

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4
Q

Cerebral Amyloid Angiopathy (+stains, 2)

A

Thioflavin-S
APP/AB

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5
Q

Dementia with Lewy Bodies (DLB)/Idiopathic Parkinsons Disease (iPD)

A

Lewy Bodies (alpha-synuclein, ubiquitin)

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6
Q

Lewy Bodies (+stains, 2)

A

Alpha-synuclein
Ubiquitin

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7
Q

Progressive Supranuclear Palsy (PSP) (4)

A

Subcortical globose tangles (silver, phospho-tau)
Grumose degeneration of cerebella’s dentate nucleus (silver)
Coiled bodies in glia (silver, phopho-tau)
Tufted astrocytes (silver, phospho-tau)

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8
Q

Subcortical globose tangles (+stains, 2)

A

PSP
-silver
-phospho-tau

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9
Q

Grumose degeneration of cerebellar dentate (+stains, 1)

A

PSP
-silver

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10
Q

Coiled bodies in glia (+stains, 2)

A

PSP
-silver
-phospho-tau

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11
Q

Tufted Astrocytes (+stains, 2)

A

PSP
-silver
-phospho-tau

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12
Q

Corticobasal Degeneration (CBD) (4)

A

Ballooned neurons (phosphorylated neurofilament proteins)
Corticobasal inclusions (silver, phospho-tau)
Coiled bodies in glia (silver, phospho-tau)
Astrocytic plaques (silver, phospho-tau)

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13
Q

Ballooned Neurons (+stains, 1)

A

CBD
-phosphorylated neurofilament protein

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14
Q

Corticobasal inclusions (+stains, 2)

A

CBD
-Silver
-Phosopho-tau

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15
Q

Coiled bodies in glia (+stains, 2)

A

CBD & PSP
-Silver
-Phosopho-tau

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16
Q

Astrocytic Plaques (+stains, 2)

A

CBD
-Silver
-Phosopho-tau

17
Q

Multiple Systems Atrophy (MSA) (1)

A

Glial cytoplasmic inclusions in Oligodendrocytes
- Silver
- Alpha-synuclein
- Ubiquitin

18
Q

Glial cytoplasmic inclusions in Oligodendrocytes (+stains, 3)

A

Multiple Systems Atrophy (MSA)
- Silver
- Alpha-synuclein
- Ubiquitin

19
Q

Pick Disease (2)

A

Pick bodies (silver, phospho-tau)
Pick cells (phosphorylated neurofilament proteins)

20
Q

Pick bodies (+stains, 2)

A

Silver
Phospho-tau

21
Q

Pick Cells (diseases-3, +stain-1)

A

Pick Disease, FTLD-tau, FTLD-U
-Phosphorylated Neurofilament protein

22
Q

Frontotemporal Lobar Degeneration with tau inclusions (FTLD-tau) (2)

A

Pick cells (phosphorylated neurofilament protein)
Glial cytoplasmic inclusions (silver, phospho-tau)

23
Q

Glial cytoplasmic inclusions (+stains, 2)

A

FTLD-tau
-Silver
-phospho-tau

24
Q

Frontotemporal Lobar Degeneration with ubiquinated inclusions (FTLD-U) (2)

A

Pick Cells (phosphorylated neurofilament protein)
Cytoplasmic and nuclear inclusions (ubiquitin, TDP-43)

25
Q

Cytoplasmic and Nuclear Inclusions (+stains, 2)

A

FTLD-U
-TDP-43
-Ubiquitin

26
Q

Creutzfeldt-Jakob Disease (CJD) (1)

A

Amyloid plaques of prion protein deposition (PrP)

27
Q

Amyloid plaques of prion protein deposition (+stain)

A

CJD
-PrP