Inclusion bodies Flashcards
unwanted materials inside RBCs, formed due to improper/ incomplete development or
maturation of cells
Inclusion bodies
–fragments of the nucleus resulting from karyorrhexis, nuclear remnants of DNA
Howell- Jolly bodies
the most specific reaction for DNA, Howell - Jolly bodies
Feulgen stain
– formed because of precipitation of ribosomes and RNA due to heavy metal poisoning
Basophilic Stipplings
because of polychromasia/polychromatophilia (: reticulocytes [remnants of
RNA])
Fine Basophilic Stippling
problem in hemoglobin synthesis (eg. if a px is intoxicated with lead
Coarse Basophilic Stippling
remnants of microtubules and mitotic spindle [bell shape, hat shape in electron microscopy]
Cabot Ring
formed because of oxidative stress, results to the denaturation of the hgb. (eg. G6PD deficiency,
thalassemia, hemoglobinopathy)
Heinz Bodies
Stained used in Heinz Bodies
Supravital stain
spleen removed the Heinz Bodies in the red cell
Bite cell (Degmacyte)
– problem with globin, associated w/ thalassemia (Supravital stain)
Hemoglobin H inclusion
accumulation of iron deposits (eg. intoxicated with lead)
Ringed sideroblast -
changes in structure of hgb, “bar of gold”
Hb CC crystals
Washington monument shaped like crystal
Hb SC crystals
confirm the presence of iron
- ringed sideroblast stain
Prussian blue (Perl’s stain)