Imunology - T Cell And B Cell Review Flashcards
What are the caracteristics of the TH1 cell?
Cell mediated immune response
Activate CD8 T cells, macrophages
Promotes specific IgG subclasse (oposonizing/complement)
What are the caracteristics of the TH2 cells?
Humoral immnunity
Activate B cells to produce antibodies
What is the interleukin produced by the macrophage that stimulates the production of TH1?
Interleukin 12 (IL-12)
What are the cytokines secreted by Th1?
IL-2 and IFN-gamma
Explain what the functions of the IL-2.
T cell growth factor
Stimulates growth CD4, CD8 T cells
Also activates B cells and NK cells
Aldesleukin for renal carcinoma and melanoma
Explain what the functions of the INF-gamma?
Activates Th1 cells / suppresses Th2 production
Activates macrophages
More MHC class I and II expression
What are the cytokines produced by the Th2?
IL-4
IL-5
IL-10
Explain what the functions of the IL-4.
Activates Th2 cells / supresses Th1 production
Promotes IgE production (parasites)
Explain what the functions of the IL-5
Activates eosinophils (helminth infection)
Promotes IgA production
Explain what the functions of the IL-10
Inhibits Th1 production
Anti inflamatory cytokine ONLY
No pro inflammatory effect
What are the genes responsible for expression self antigens?
AIRE Genes - Autoimune regulator
What are the clinical consequences of the mutation the AIRE genes?
Autoimmune disease
Recorrent candida infections
Chronic mucocutaneous candidiasis
Hypoparathyroidism
Adrenal insufficiency
What is the portion of the antibodies that complement binds?
CH2
Among which portions of the antibody do macrophages and protein A bind?
CH2-CH3
