Imunology - T Cell And B Cell Review Flashcards

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1
Q

What are the caracteristics of the TH1 cell?

A

Cell mediated immune response
Activate CD8 T cells, macrophages
Promotes specific IgG subclasse (oposonizing/complement)

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2
Q

What are the caracteristics of the TH2 cells?

A

Humoral immnunity
Activate B cells to produce antibodies

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3
Q

What is the interleukin produced by the macrophage that stimulates the production of TH1?

A

Interleukin 12 (IL-12)

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4
Q

What are the cytokines secreted by Th1?

A

IL-2 and IFN-gamma

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5
Q

Explain what the functions of the IL-2.

A

T cell growth factor
Stimulates growth CD4, CD8 T cells
Also activates B cells and NK cells
Aldesleukin for renal carcinoma and melanoma

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6
Q

Explain what the functions of the INF-gamma?

A

Activates Th1 cells / suppresses Th2 production
Activates macrophages
More MHC class I and II expression

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7
Q

What are the cytokines produced by the Th2?

A

IL-4
IL-5
IL-10

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8
Q

Explain what the functions of the IL-4.

A

Activates Th2 cells / supresses Th1 production
Promotes IgE production (parasites)

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9
Q

Explain what the functions of the IL-5

A

Activates eosinophils (helminth infection)
Promotes IgA production

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10
Q

Explain what the functions of the IL-10

A

Inhibits Th1 production
Anti inflamatory cytokine ONLY
No pro inflammatory effect

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11
Q

What are the genes responsible for expression self antigens?

A

AIRE Genes - Autoimune regulator

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12
Q

What are the clinical consequences of the mutation the AIRE genes?

A

Autoimmune disease
Recorrent candida infections
Chronic mucocutaneous candidiasis
Hypoparathyroidism
Adrenal insufficiency

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13
Q

What is the portion of the antibodies that complement binds?

A

CH2

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14
Q

Among which portions of the antibody do macrophages and protein A bind?

A

CH2-CH3

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