Imunitatea inascuta Flashcards

1
Q

Peptide antimicrobiene cu greutate moleculara mica:

A
  1. Cathelicidine- AA dispuse helicoidal; se insera in membranele bacteriene
  2. Defensine- oligopeptide cu 3 punti disulfidice intre resturi CYS
    alfa- se insera in mb. bact.
    beta- secretate activ
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2
Q

PAMP exemple:

A
  1. LPZ la gram negative
  2. peptidoglicani si acizi lipoteichoici G poz
  3. Manoza- glicolipide, glicoproteine microbiene
  4. Fragmente de ADN bact, ARN virusuri
  5. Glicani din fungi
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3
Q

DAMP exemple

A
  1. Fragmente de acid nucleic
  2. HSP
  3. Fregmente de receptori de pe membrane
  4. Fragmente de degradare ale acidului hialuronic
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4
Q

Colectine respiratorii:

A

Proteine surfactant A-D

MBL/MBP- manoze binding protein

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5
Q

Colectine- lectine intestinale:

A
  1. Anti-helminti: rezistin-like molecula beta
  2. Proteina permeabilizanta/bactericida- neutralizeaza LPZ gram negative
  3. Lectine antimicrobiene intestinale- opsonine pt gram poz.
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6
Q

Mecanism imunologic al cernelei din tatuaje:

A

Varianta de evolutiei a ag. incomplete/ haptenei care reuseste sa scapa de opsonina si sa nu fie nici legata; depozitandu-se in sistemul reticulo-endotelial.

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7
Q

Ag nativ:

A

Ag proaspat intrat in organism. Niciodata R.I. nu este declansat fata de intreaga structura a Ag nativ.

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8
Q

Fragmente ignorate imunologic:

A

Olugipeptide mai mici de 8 aa.

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9
Q

Fragmentele care au intre 8-15aa:

A

Epitopi de tip T

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10
Q

Fragmentele care au intre 15-45aa:

A

Epitopii de tip B

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11
Q

95% din totalul Ag naturale sunt;

A

T-dep

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12
Q

RIU primar are caracteristic:

A

igM

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13
Q

Singurele molecule care recunosc MHCII:

A

LyTh

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