Imtegumentary Meds ( Chap 51)

Question 1

For meds to Treat Atopic Dermatitis ( eczema)

Answer 1

Systemic Immunosuppressants
■ Azathioprine (Imuran)
■ Cyclosporine (Sandimmune)
■ Methotrexate
■ Oral glucocorticoids Topical

Immunosuppressants
■ Pimecrolimus 1% cream (Elidel)
■ Tacrolimus (Protopic)

Question 2

What are some side effects of Topical immunosuppressants?

Tacrolimus (Protopic 0.03% or 0.1% cream) and pimecrolimus 1% cream (Elidel).

Answer 2

Side/adverse effects include redness, burning, and itching; causes sensitization of the skin to sunlight.

Tacrolimus increases the risk of varicella-zoster infection in children.

Tacrolimus may cause skin cancer and lymphoma.

Question 3

Topical glucocorticoids can be absorbed into the systemic circulation; absorption is _______ in permeable skin areas (scalp, axilla, face and neck, eyelids, perineum) and ______ in areas where permeability is poor (palms, soles, back).

Answer 3

Greater, less

Question 4

For long term therapy of topical glucocorticoids, what plasma levels need to be monitored???

Answer 4

cortisol

Question 5

What is actinic keratoses ?

Answer 5

caused by prolonged exposure to the sun and appear as
rough, scaly, red or brown lesions usually found on the face, scalp, arms, and back of the hands.

Question 6

What type of sunscreen absorbs UV light? And what type reflects and scatters UV sunlight?

Answer 6

Organic (chemical) sunscreens absorb UV light; inorganic (physical) sunscreens reflect and scatter UV light.

Question 7

A sunscreen that protects against both UVB and UVA rays and one that has a sun protection factor (SPF) of at least \_\_\_\_\_\_should be used.
A. 15
B. 30
C. 50
D. 60

Answer 7

A . 15

Question 8

Sunscreens are most effective when applied at least ______ minutes before exposure to the sun

Answer 8

30 minutes

(sunscreens containing para-aminobenzoic acid [PABA] or padimate O require application 2 hours before sun exposure).

Question 9

What types of medications treat psoriasis ?

Answer 9

Topical Medications
■ Anthralin (Dritho-Scalp, Psoriatec)
■ Calcipotriene (Dovonex)
■ Coal tar
■ Glucocorticoids
■ Keratolytics (topical salicylic acid; sulfur)
■ Tazarotene (Tazorac)

Systemic Medications ■ Acitretin (Soriatane) ■ Cyclosporine
■ Methotrexate
Systemic Biological Medications ■ Alefacept (Amevive)
■ Ustekinumab (Stelara)
Photothe rapy
■ Coal tar and ultraviolet B irradiation
■ Photochemotherapy (PUVA [psoralen and ultraviolet A] therapy)

Question 10

What type of condition is shown as streaked” blisters surrounding one large blister.

Answer 10

Poison ivy