Important Facts

Question 1

Severe Diarrhea

Answer 1

Irinotecan

Question 2

Cardio toxicity

Answer 2

Antracyclines
Anthracenedione (lesser extent)
Lapatinib (Tykerb)
Fluorouracil (Adrucil)

Question 3

Vesicant IV agents

Answer 3

Anthracyclines

Question 4

Hand Foot Syndrome

Answer 4

Doxil
Fluorouracil
MTX
Pemetrexed (Alimta)

Question 5

Bilirubin dose adjustment

Answer 5

Anthracyclines
Fluorouracil
Bortezomib (Velcade)

Question 6

Agent that needs PCP Prophylaxis

Answer 6

Temodar

Fludarabine (needs viral and fungal proph also)

Question 7

Agents that cause Radiation recall

Answer 7

Anthracyclines

Question 8

Agents needing hepatic adjustment

Answer 8

Temodar
Irinotecan 
Ifosfamide
Cyclophosphamide 
Carmustine

Question 9

Agents needing renal adjustment

Answer 9

Bendamustine
Carmustine
Cyclophosphamide
Ifosfamide
Melphalan
-Platins
Topotecan
Temodar

Question 10

Agents causing severe myelosuppression

Answer 10

Carmustine
Topotecan
Carboplatin

Question 11

Agents that are prodrugs

Answer 11

Cyclophosphamide
Ifosfamide
Irinotecan
Fludarabine

Question 12

Agents that cause hemorrhagic cystitis

Answer 12

Cyclophosphamide

Ifosfamide

Question 13

Agent(s) that need coadministration of Mesna

Answer 13

Ifosfamide (always)

Cyclophosphamide (doses >1.5g/m2)

Question 14

Agent that causes SEVERE skin rash

Answer 14

Bendamustine

Question 15

Agent that requires central line administration

Answer 15

Busulfan

Question 16

Agent that PO formulation is taken on an empty stomach and IV formulation must be administered within 1 hour of reconstitution

Answer 16

Melphalan (Alkeran)

Question 17

Agents that need non-DEHP “Taxol Tubing”

Answer 17

Cetuximab (Erbitux)
Etoposide (Toposar/Etopophos)
Paclitaxel (Taxol)
Docetaxel (Taxotere)
Ixempra

Question 18

CYP 2C9 Inhibitors

Answer 18

5-FU (Adrucil)

Capecitabine (Xeloda)

Question 19

Cerebellar syndrome agents

Answer 19

Cytarabine

Fluorouracil

Question 20

Contraindicated with CrCl

Answer 20

Xeloda…PO Fluorouracil

Question 21

Agents contraindicated with Intrathecal administration

Answer 21

Vinca alkaloids

Question 22

3 A4 substrates

Answer 22

Lapatinib (Tykerb)

Bortezomib (Velcade)

Question 23

Which agent can you not have green tea or vitamin C with?

Answer 23

Bortezomib (Velcade)

Question 24

G2/M phase agents

Answer 24

Bortezomib (Velcade)
Vincas
Taxanes

Question 25

Premedication for Pemetrexed (Alimta)

Answer 25

Dexamethasone (day before, day of, day after) Folate (1 week before tx, during tx, 21 days after tx) Vitamin B12 (IM injection 1 wk before & then every 3 cycles)

Question 26

G2 phase agent

Answer 26

Etoposide

Question 27

Which HER-2 Disease target drugs can be used in the metastatic setting?

Answer 27

All 4 - trastuzumab (Herceptin) - lapatinib (Tykerb) - pertuzumab (Perjeta) - T-DM1 Ado-Trastuzumab (Kadcyla)

Question 28

Which HER-2 Disease target drugs can be used in the Adjuvant setting?

Answer 28

Trastuzumab (Herceptin)

Question 29

Which HER-2 Disease target drugs can be used in the Neo-adjuvant setting?

Answer 29

Pertuzumab (Perjeta)