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Oncology > Important Facts > Flashcards

Important Facts Flashcards

1
Q

Severe Diarrhea

A

Irinotecan

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2
Q

Cardio toxicity

A

Antracyclines
Anthracenedione (lesser extent)
Lapatinib (Tykerb)
Fluorouracil (Adrucil)

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3
Q

Vesicant IV agents

A

Anthracyclines

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4
Q

Hand Foot Syndrome

A

Doxil
Fluorouracil
MTX
Pemetrexed (Alimta)

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5
Q

Bilirubin dose adjustment

A

Anthracyclines
Fluorouracil
Bortezomib (Velcade)

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6
Q

Agent that needs PCP Prophylaxis

A

Temodar

Fludarabine (needs viral and fungal proph also)

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7
Q

Agents that cause Radiation recall

A

Anthracyclines

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8
Q

Agents needing hepatic adjustment

A 
Temodar
Irinotecan 
Ifosfamide
Cyclophosphamide 
Carmustine
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9
Q

Agents needing renal adjustment

A 
Bendamustine
Carmustine
Cyclophosphamide
Ifosfamide
Melphalan
-Platins
Topotecan
Temodar
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10
Q

Agents causing severe myelosuppression

A

Carmustine
Topotecan
Carboplatin

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11
Q

Agents that are prodrugs

A

Cyclophosphamide
Ifosfamide
Irinotecan
Fludarabine

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12
Q

Agents that cause hemorrhagic cystitis

A

Cyclophosphamide

Ifosfamide

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13
Q

Agent(s) that need coadministration of Mesna

A

Ifosfamide (always)

Cyclophosphamide (doses >1.5g/m2)

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14
Q

Agent that causes SEVERE skin rash

A

Bendamustine

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15
Q

Agent that requires central line administration

A

Busulfan

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16
Q

Agent that PO formulation is taken on an empty stomach and IV formulation must be administered within 1 hour of reconstitution

A

Melphalan (Alkeran)

17
Q

Agents that need non-DEHP “Taxol Tubing”

A 
Cetuximab (Erbitux)
Etoposide (Toposar/Etopophos)
Paclitaxel (Taxol)
Docetaxel (Taxotere)
Ixempra
18
Q

CYP 2C9 Inhibitors

A

5-FU (Adrucil)

Capecitabine (Xeloda)

19
Q

Cerebellar syndrome agents

A

Cytarabine

Fluorouracil

20
Q

Contraindicated with CrCl

A

Xeloda…PO Fluorouracil

21
Q

Agents contraindicated with Intrathecal administration

A

Vinca alkaloids

22
Q

3 A4 substrates

A

Lapatinib (Tykerb)

Bortezomib (Velcade)

23
Q

Which agent can you not have green tea or vitamin C with?

A

Bortezomib (Velcade)

24
Q

G2/M phase agents

A

Bortezomib (Velcade)
Vincas
Taxanes

25
Q

Premedication for Pemetrexed (Alimta)

A

Dexamethasone (day before, day of, day after)

Folate (1 week before tx, during tx, 21 days after tx)

Vitamin B12 (IM injection 1 wk before & then every 3 cycles)

26
Q

G2 phase agent

A

Etoposide

27
Q

Which HER-2 Disease target drugs can be used in the metastatic setting?

A

All 4

  • trastuzumab (Herceptin)
  • lapatinib (Tykerb)
  • pertuzumab (Perjeta)
  • T-DM1 Ado-Trastuzumab (Kadcyla)
28
Q

Which HER-2 Disease target drugs can be used in the Adjuvant setting?

A

Trastuzumab (Herceptin)

29
Q

Which HER-2 Disease target drugs can be used in the Neo-adjuvant setting?

A

Pertuzumab (Perjeta)

Oncology (12 decks)

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