Important Drug Toxicities Flashcards
1
Q
Hemorrhagic cystitis:
A
- Cyclophosamide
2
Q
Alopecia:
A
- Steroids
- Heparin
3
Q
Alopecia def:
A
Alopecia simply means hair loss (baldness).
4
Q
Coronary spasm:
A
Cocaine
5
Q
Tradive dyskinesia:
A
Antipsychotics*
5
Q
Cough:
A
ACE inhibitors
6
Q
Fanconi syndrome:
A
Expired tetracycline**
7
Q
Atropine-like side effects:
A
TCA (tricyclic antidepressants)
8
Q
Grey baby syndrome:
A
Chloramphenicol
9
Q
Pseudomembranous colitis:
A
- Clindamycin*
- Ampicillin*
- Cephalosporins
- FLQ (fluoroquinolones)
10
Q
Pulmonary infiltrate:
A
Bromocriptine
11
Q
Kidney stones:
A
- Lamotrigine
- Zonisande
- Indanavir
- Topiramate
- Acetazolamide
- Vit. D
11
Q
Neuro- and nephropathy:
A
- Polymyxin*
- Cyclosporine
- FLQ (fluoroquinolones)
- Tacrolimus
12
Q
Gingival hyperplasia:
A
- Phenytoin*
- Cyclosporine
- CCB
13
Q
Diabetes insipidus:
A
- Lithium*
- Phenytoin
- Foscarnet
14
Q
Extrapyramydial side effects:
A
Typical anipsychotics*:
- Chlorpromazine*
- Thioridazine*
- Haloperidol*
15
Q
Extrapyramidal side effects:
A
- Traditional antipsychotics
- Metyrosine
16
Q
Pancreatitis:
A
- GCS (Glucocortico steroids)
- Asparaginase
- Didanosine
17
Q
Osteoporosis:
A
- Cotricosteroids*
- Heparin*
- Phenytoin
18
Q
Peripheral neuropathy:
A
- Vincristine
- Vinblastine
- Docetaxel
- Pacitaxel
19
Q
Hyperuricemia:
A
- Aspirin
- Thiazide
- Pyrazinamide
- Ethambutol
- Clofibrate
- Niacin
21
Q
Optic neuritis:
A
- Ethambutol
- Amiodarone
22
Q
Peripheral neuritis:
A
Isoniazid
* add pyridoxine “vit.B6” to reverse this problem
23
Q
Hyperlipidemia:
A
- Thiazides
- β-blockers
24
Rhabdomyolysis:
Statins
| * mannitol is used to treat it
25
Torsades de pointes:
- Class III and Class IA anti-arrhythmics
* Class III (Sotalol, rare with Amiodarone)
* Class IA (Quinidine)
26
Drug-induced parkinsonism:
- Haloperidol*
- Chlorpromazine*
- Reserpine*
- MPTP*
27
Otoxicity and nephrotoxicity:
- Aminoglycosides*
- Loop diuretics (fursemide)*
- Cisplatin*
- Vancomycin (older preparations)
29
Disulfiram-like-reaction:
- Metronidazole*
- Certain cephalosporin (cefotetan/cefoperazone)*
- Procarbazine*
- Sulfonylureas*
30
Hypertrichosis:
- Hydralazine
- Minoxidil
- Aspirin
- Phenytoin
31
Tendonitis, tendon rupture and cartilage damage:
Fluoroquinolones
32
Drug-induced megaloblastic anemia:
- Lithium
- Pheytoin
- Nitrous oxide
- Purine synthesis anagonists (6-mercaptourine)
- Primidone (antieleptic)
- Valproic acid
- Ziduvodine
- Pyrazinamide
- Orlistat
- Sulfonamide
- Trimethoprim/pyrimethamine
33
Stevens-Johnson syndrome:
- Ethosuximide*
- Sulfonamide*
- Lamotrigine*
- Phenobarbital
- Carbamazepine
- Zoniasmide
34
Agranulocytosis:
- Clozapine*
- Carbamazepine*
- Colchicine*
- Ticlopidine
- Sulfonylurease (rare)
- Sulfonamide (rare)
- Thiamides (propylthiouracil, methimazole) pheylbutazone
35
Cardiotoxicity:
- Doxorubicin
- Daunrubicine
- Interferone
- TCA (ventricular dysthmias)
- Halothene
- Enlurane
- Trastuzumab
36
Redish brownish skin:
Clofizimine
37
Redish color of the urine:
- Rifampin
| - Doxorubicin/Daunrubicine
38
Blue skin:
Amiodarone
39
Brown urine:
- Levodopa
| - Nitrofurantoin
40
Thyroid dysfunction:
- Amiodarone (hypo/hyper)
- Interferon
- Lithium (hypothyroidism)
41
Cutaneous flushing:
- Niacin*
- Calcium channel blockers*
- Adenosine*
- Vancomycin (red man syndrome)*
- Caspofungin
42
Corneal micro deposits:
Amiodarone
43
Hot flashes:
- Tamoxifen*
- Nitrite
- Androgen blockers (-lutamides)
- GnRH analogs
- Aromatase inhibitors (letrozole, exemstane)
44
Tubulointerstitial nephritis:
- Sulfonamide*
- Furosemide*
- Methicillin*
- Rifampin*
- NSAIDs (except for aspirin)*
45
OCP =
Oral contraceptive pill
46
Photosensitivity:
- Sulfonamides*
- Amiodarone*
- Tetracyclines*
(SAT for a photo)
- FLQ*
47
Adrenocortical insufficiency:
Withdrawal from glucocorticosteroids (HPA suppression)
48
Thrombotic complications:
- OCP (estrogen and progestin)
* Tamoxifen
* Raloxifen
49
Hemolysis in G6PD deficient patients:
- Sulfonamides*
- INH*
- Aspirin*
- Ibuprofen*
- Primaquine*
- Nitrofurantoin*
- Pyrimethamine*
- Chloramphenicol*
50
SLE-like syndrome:
| SLE=Systemic lupus erythematosus
- Hydralazine*
- Isoniazid*
- Procainamide*
- Phenytoin*
(it is not HIPP to have lupus)
- Methyldopa
51
Focal to massive hepatic necrosis:
- Acetaminophen*
- Amanita phalloides*
- Amiodarone
- Nefazodone
- Tacrine
- Flebamate
- 6-mercaptupurine
- 6-Thioguanine
- Tolcapone (not entacapone)
- Niacin
- Rosiglitazone
- Picglitazone
- Troglitazone
- Decarbazine
- MTX
- Anaphylaxis-Penicillin(?)
52
Hepatitis:
- Isoniazid*
- Halothane*
- Sulfasalazine
- Flutamide
- Bicalutamide
- Methyl Dopa
- Oral androgens
- Naltrexone
- Propylthiouracil
53
Pulmonary fibrosis:
- Bleomycin*
- Amiodarone*
- Busulfan*
- Nitrofurantoin
- Melphalan
- Tocainamide (rare)
- Lomustine
54
Aplastic anemia:
- Chloramphenicol*
- Benzene*
- NSAIDs*
- Mexiletine
- Tocainide
- Thioamide
- Vinblastine
- Carbamazepine
- Ethosuxamide
- Sulfonylurease (rare)
- Phenylbutazone
- Pencillamin
- Gold salts
- Colchicine
- Cispride
55
Gynecomastia:
- Spironolactone
- Digitalis
- Cimetidine
- Chronic alcohol use
- Morphene
- Traditional antipsychotics
- Estrogen
- Ketoconazole
- Methyl dopa
