Important cytokines

Question 1

IL-1

Answer 1

Endogenous pyrogen
Causes fever and acute inflammation
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes
Secreted by macrophages

Question 2

IL-2

Answer 2

Stimulates T cell growth (THCs, CTLs, and Tregs)

Secreted by all T cells

Question 3

IL-3

Answer 3

Stimulates growth and differentiation of bone marrow stem cells (functions like GM-CSF)
Secreted by all T cells

Question 4

IL-4

Answer 4

Induces differentiation –>TH2 cells
Promotes B cell growth
Stimulates class switching to IgE & IgG
Secreted by TH2 cells

Question 5

IL-5

Answer 5

Promotes P cell differentiation
Stimulates growth and differentiation of eosinophils
Stimulates class switching to IgA
Secreted by TH2 cells

Question 6

IL-6

Answer 6

Endogenous pyrogen
Causes fever and stimulates production of acute phase proteins
Secreted by macrophages and TH2 cells

Question 7

IL-8

Answer 7

Major chemotactic factor for neutrophils

Question 8

IL-12

Answer 8

Induces differentiation of T cells–>TH1 cells
Activates NKCs
Secreted by macrophages and B cells

Question 9

TNF-alpha

Answer 9

Mediates septic shock
Activates endothelium
Causes leukocyte recruitment and vascular leak
Secreted by macrophages

Question 10

IFN-gamma

Answer 10

Activates macrophages and TH1 cells
Suppresses TH2 cells
Has antiviral and antitumor properties
Secreted by TH1 cells

Question 11

IL-10

Answer 11

Modulates inflammatory response
Inhibits actions of activated T cells and TH1 cells.
Secreted by TH2 cells and Tregs
Actions are similar to TGF-beta